SF-Assemblin genes in Paramecium: phylogeny and phenotypes of RNAi silencing on the ciliary-striated rootlets and surface organization [0.03%]
斜纹根毛和表面结构的RNA干扰表型及进化基因组学研究：模式物种变形虫中的SF-Assemblin基因家族分析
Ashikun Nabi,Junji Yano,Megan S Valentine et al.
Ashikun Nabi et al.
Background: Cilia emanate from basal bodies just underneath the cell membrane. Basal bodies must withstand torque from the ciliary beat and be appropriately spaced for cilia to beat in metachronal waves. Basal body rootle...
Max C Lauring,Tianqi Zhu,Wei Luo et al.
Max C Lauring et al.
Background: Primary cilia frequency and length are key metrics in studies of ciliogenesis and ciliopathies. Typically, quantitative cilia analysis is done manually, which is very time-consuming. While some open-source and...
Max C Lauring,Tianqi Zhu,Wei Luo et al.
Max C Lauring et al.
Background: Primary cilia frequency and length are key metrics in studies of ciliogenesis and ciliopathies. Typically, quantitative cilia analysis is done manually, which is very time-consuming. While some open-source and...
Cellular ciliary phenotyping indicates pathogenicity of novel variants in IFT140 and confirms a Mainzer-Saldino syndrome diagnosis [0.03%]
基于IFT140的新变异的细胞纤毛表型分析判断其致病性并确认Mainzer-Saldino综合征诊断
Machteld M Oud,Brooke L Latour,Zeineb Bakey et al.
Machteld M Oud et al.
Background: Mainzer-Saldino syndrome (MZSDS) is a skeletal ciliopathy and part of the short-rib thoracic dysplasia (SRTD) group of ciliary disorders. The main characteristics of MZSDS are short limbs, mild narrow thorax, ...
Glioma cell proliferation is enhanced in the presence of tumor-derived cilia vesicles [0.03%]
肿瘤衍生的纤毛小体囊泡可增强胶质母细胞瘤细胞增殖
Lan B Hoang-Minh,Marina Dutra-Clarke,Joshua J Breunig et al.
Lan B Hoang-Minh et al.
Background: The mechanisms by which primary cilia affect glioma pathogenesis are unclear. Depending on the glioma cell line, primary cilia can promote or inhibit tumor development. Here, we used piggyBac-mediated transgen...
Amyloid-β interrupts canonical Sonic hedgehog signaling by distorting primary cilia structure [0.03%]
淀粉样蛋白-β通过破坏主纤毛结构来干扰经典刺猬信号通路
Anna G Vorobyeva,Aleister J Saunders
Anna G Vorobyeva
Background: Primary cilia are small non-motile microtubule and cell membrane protrusions expressed on most vertebrate cells, including cortical and hippocampal neurons. These small organelles serve as sensory structures s...
Sarbjot Kaur,Sue R McGlashan,Marie-Louise Ward
Sarbjot Kaur
Background: A transient increase in cytosolic Ca2+ (the "Ca2+ transient") determines the degree and duration of myocyte force development in the heart. However, we have previously observed that, under the same experimenta...
Sensing the cilium, digital capture of ciliary data for comparative genomics investigations [0.03%]
感知纤毛：纤毛数据的数字化采集以用于比较基因组学研究
Karen R Christie,Judith A Blake
Karen R Christie
Background: Cilia are specialized, hair-like structures that project from the cell bodies of eukaryotic cells. With increased understanding of the distribution and functions of various types of cilia, interest in these or...
Assaying sensory ciliopathies using calcium biosensor expression in zebrafish ciliated olfactory neurons [0.03%]
使用斑马鱼纤毛嗅觉神经元中的钙生物传感器检测感觉纤毛病
Judith G M Bergboer,Cameron Wyatt,Christina Austin-Tse et al.
Judith G M Bergboer et al.
Background: Primary cilia mediate signal transduction by acting as an organizing scaffold for receptors, signalling proteins and ion channels. Ciliated olfactory sensory neurons (OSNs) organize olfactory receptors and ion...
Paola Roncaglia,Teunis J P van Dam,Karen R Christie et al.
Paola Roncaglia et al.
Background: Recent research into ciliary structure and function provides important insights into inherited diseases termed ciliopathies and other cilia-related disorders. This wealth of knowledge needs to be translated in...