H Lynn Kee,Kristen J Verhey
H Lynn Kee
As an organelle, the cilium contains a unique complement of protein and lipid. Recent work has begun to shed light on the mechanisms that regulate entry of ciliary proteins into the compartment. Here, we focus on the mechanisms that regulat...
Sagar Bhogaraju,Benjamin D Engel,Esben Lorentzen
Sagar Bhogaraju
Intraflagellar transport (IFT) is required for the assembly and maintenance of cilia, as well as the proper function of ciliary motility and signaling. IFT is powered by molecular motors that move along the axonemal microtubules, carrying l...
An inducible CiliaGFP mouse model for in vivo visualization and analysis of cilia in live tissue [0.03%]
一种用于在活组织中对纤毛进行体内可视化和分析的可诱导型CiliaGFP小鼠模型
Amber K O&#x;Connor,Erik B Malarkey,Nicolas F Berbari et al.
Amber K O&#x;Connor et al.
Background: Cilia are found on nearly every cell type in the mammalian body, and have been historically classified as either motile or immotile. Motile cilia are important for fluid and cellular movement; however, the rol...
The SYSCILIA gold standard (SCGSv1) of known ciliary components and its applications within a systems biology consortium [0.03%]
SYSCILIA纤毛组分金标准(SCGSv1)及其在系统生物学联盟中的应用
Teunis Jp van Dam,Gabrielle Wheway,Gisela G Slaats;SYSCILIA Study Group;Martijn A Huynen et al.
Teunis Jp van Dam et al.
The multinational SYSCILIA consortium aims to gain a mechanistic understanding of the cilium. We utilize multiple parallel high-throughput (HTP) initiatives to develop predictive models of relationships between complex genotypes and variabl...
Functional aspects of primary cilia in signaling, cell cycle and tumorigenesis [0.03%]
纤毛在信号转导、细胞周期及肿瘤发生中的功能作用
Sander G Basten,Rachel H Giles
Sander G Basten
Dysfunctional cilia underlie a broad range of cellular and tissue phenotypes and can eventually result in the development of ciliopathies: pathologically diverse diseases that range from clinically mild to highly complex and severe multi-or...
The effect of ethanol and acetaldehyde on brain ependymal and respiratory ciliary beat frequency [0.03%]
乙醇和乙醛对大脑脑室脉络丛及呼吸上皮纤毛摆动频率的影响
Claire Mary Smith,Priya Radhakrishnan,Kulvinder Sikand et al.
Claire Mary Smith et al.
Background: Ethanol has been shown to stimulate the beat frequency of respiratory cilia at concentrations encountered during social drinking, while one of its metabolites, acetaldehyde, has been shown to cause a marked de...
First International Cilia in Development and Disease Scientific Conference (2012) London, UK. 16-18 May 2012. Abstracts [0.03%]
首届国际纤毛在发育和疾病中的作用科学会议（2012）伦敦，英国。2012年5月16-18日。摘要集
Hannah M Mitchison,Philip L Beales
Hannah M Mitchison
Pancreatic cyst development: insights from von Hippel-Lindau disease [0.03%]
Von Hippel-Lindau病人的胰腺囊性病变的发展状况分析研究
Sophie J van Asselt,Elisabeth Ge de Vries,Hendrik M van Dullemen et al.
Sophie J van Asselt et al.
Pancreatic cysts are a heterogeneous group of lesions, which can be benign or malignant. Due to improved imaging techniques, physicians are more often confronted with pancreatic cysts. Little is known about the origin of pancreatic cysts in...
Reduced cilia frequencies in human renal cell carcinomas versus neighboring parenchymal tissue [0.03%]
人肾细胞癌与邻近肾组织中纤毛频率降低
Sander G Basten,Sven Willekers,Joost Sp Vermaat et al.
Sander G Basten et al.
Background: Cilia are essential organelles in multiple organ systems, including the kidney where they serve as important regulators of renal homeostasis. Renal nephron cilia emanate from the apical membrane of epithelia, ...
Katarzyna Szymanska,Colin A Johnson
Katarzyna Szymanska
Recent studies of the primary cilium have begun to provide further insights into ciliary ultrastructure, with an emerging picture of complex compartmentalization and molecular components that combine in functional modules. Many proteins tha...