Ultrastructural visualization of trans-ciliary rhodopsin cargoes in mammalian rods [0.03%]
哺乳动物视杆细胞中穿过睫状体的视紫红质货物的超微结构可视化
Jen-Zen Chuang,Ya-Chu Hsu,Ching-Hwa Sung
Jen-Zen Chuang
Background: Cilia are vital to various cellular and sensory functions. The pathway by which ciliary membrane proteins translocate through the transition zone is not well understood. Direct morphological characterization o...
Takashi Ishikawa
Takashi Ishikawa
Cryo-electron tomography has been a valuable tool in the analysis of 3D structures of cilia at molecular and cellular levels. It opened a way to reconstruct 3D conformations of proteins in cilia at 3-nm resolution, revealed networks of a nu...
Claudius Werner,Jörg Große Onnebrink,Heymut Omran
Claudius Werner
Primary ciliary dyskinesia (PCD) is a rare autosomal recessive disorder with defective structure and/or function of motile cilia/flagella, causing chronic upper and lower respiratory tract infections, fertility problems, and disorders of or...
Situs inversus and ciliary abnormalities: 20 years later, what is the connection? [0.03%]
sito inversus和纤毛异常：20年后，它们之间的联系是什么？
Petra Pennekamp,Tabea Menchen,Bernd Dworniczak et al.
Petra Pennekamp et al.
Heterotaxy (also known as situs ambiguous) and situs inversus totalis describe disorders of laterality in which internal organs do not display their typical pattern of asymmetry. First described around 1600 by Girolamo Fabrizio, numerous ca...
Remodeling Cildb, a popular database for cilia and links for ciliopathies [0.03%]
重建用于纤毛和纤毛病相关链接的流行数据库Cildb
Olivier Arnaiz,Jean Cohen,Anne-Marie Tassin et al.
Olivier Arnaiz et al.
Background: New generation technologies in cell and molecular biology generate large amounts of data hard to exploit for individual proteins. This is particularly true for ciliary and centrosomal research. Cildb is a mult...
Lotte B Pedersen
Lotte B Pedersen
Identification of conserved, centrosome-targeting ASH domains in TRAPPII complex subunits and TRAPPC8 [0.03%]
在TRAPPIII复合体亚基和TRAPPC8中鉴定出一种保守的、定位于中心粒的ASH结构域
Kenneth B Schou,Stine K Morthorst,Søren T Christensen et al.
Kenneth B Schou et al.
Background: Assembly of primary cilia relies on vesicular trafficking towards the cilium base and intraflagellar transport (IFT) between the base and distal tip of the cilium. Recent studies have identified several key re...
Ina Menzl,Lauren Lebeau,Ritu Pandey et al.
Ina Menzl et al.
Background: Primary cilia are microtubule-based organelles that protrude from the cell surface. Primary cilia play a critical role in development and disease through regulation of signaling pathways including the Hedgehog...
Mitochondrial fusion protein MFN2 interacts with the mitostatin-related protein MNS1 required for mouse sperm flagellar structure and function [0.03%]
线粒体融合蛋白MFN2与类似mitostatin的蛋白质MNS1相互作用，该蛋白对小鼠精子鞭毛结构和功能是必需的
Melissa L Vadnais,Angel M Lin,George L Gerton
Melissa L Vadnais
Background: Cilia and the sperm flagellum share many structural properties. Meiosis-specific nuclear structural 1 (MNS1) is a recently characterized protein that is abundantly expressed in post-meiotic spermatids and is r...
Normal mammary development and function in mice with Ift88 deleted in MMTV- and K14-Cre expressing cells [0.03%]
Ift88在MMTV-和K14-Cre表达细胞中被删除的小鼠正常发育及乳腺功能的研究
Elizabeth H Mitchell,Rosa Serra
Elizabeth H Mitchell
Background: Primary cilia (PC) are non-motile microtubule based organelles present on almost every cell type and are known to serve as critical organizing centers for several signaling pathways crucial to embryonic and po...