Basal bodies in Xenopus [0.03%]
非洲爪蟾的基体
Siwei Zhang,Brian J Mitchell
Siwei Zhang
Xenopus has been one of the earliest and most important vertebrate model organisms for investigating the role and structure of basal bodies. Early transmission electron microscopy studies in Xenopus revealed the fine structures of Xenopus b...
Brian A Bayless,Domenico F Galati,Chad G Pearson
Brian A Bayless
Tetrahymena thermophila is a ciliate with hundreds of cilia primarily used for cellular motility. These cells propel themselves by generating hydrodynamic forces through coordinated ciliary beating. The coordination of cilia is ensured by t...
Current topics of functional links between primary cilia and cell cycle [0.03%]
原纤毛与细胞周期之间功能联系的当前研究主题
Ichiro Izawa,Hidemasa Goto,Kousuke Kasahara et al.
Ichiro Izawa et al.
Primary cilia, microtubule-based sensory structures, orchestrate various critical signals during development and tissue homeostasis. In view of the rising interest into the reciprocal link between ciliogenesis and cell cycle, we discuss her...
Yi Chung Lim,Sue R McGlashan,Michael T Cooling et al.
Yi Chung Lim et al.
Background: The primary cilium is a sensor of blood-induced forces in endothelial cells (ECs). Studies that have examined EC primary cilia have reported a wide range of cilia incidence (percentage of ciliated cells). We h...
Comparing the Bbs10 complete knockout phenotype with a specific renal epithelial knockout one highlights the link between renal defects and systemic inactivation in mice [0.03%]
Bbs10完全敲除型与特定肾上皮细胞系敲除型小鼠表型的比较，强调了肾脏缺陷与全身失活之间的联系
Noëlle Cognard,Maria J Scerbo,Cathy Obringer et al.
Noëlle Cognard et al.
Background: Bardet-Biedl Syndrome (BBS) is a genetically heterogeneous ciliopathy with clinical cardinal features including retinal degeneration, obesity and renal dysfunction. To date, 20 BBS genes have been identified w...
The Drosophila homologue of Rootletin is required for mechanosensory function and ciliary rootlet formation in chordotonal sensory neurons [0.03%]
果蝇机械感觉神经元中根蛋白同源物基因rootletin的鉴定及其在纤毛根丝形成和机械感受功能中的作用研究
Katarzyna Styczynska-Soczka,Andrew P Jarman
Katarzyna Styczynska-Soczka
Background: In vertebrates, rootletin is the major structural component of the ciliary rootlet and is also part of the tether linking the centrioles of the centrosome. Various functions have been ascribed to the rootlet, ...
Non-invasive sources of cells with primary cilia from pediatric and adult patients [0.03%]
来自儿科和成人患者的初级纤毛非侵入性细胞来源
Henry Ajzenberg,Gisela G Slaats,Marijn F Stokman et al.
Henry Ajzenberg et al.
Background: Ciliopathies give rise to a multitude of organ-specific pathologies; obtaining relevant primary patient material is useful for both diagnostics and research. However, acquisition of primary ciliated cells from...
The primary cilium functions as a mechanical and calcium signaling nexus [0.03%]
初级纤毛充当力学和钙信号传递中心的功能
Kristen L Lee,Marie D Guevarra,An M Nguyen et al.
Kristen L Lee et al.
Background: The primary cilium is an antenna-like, nonmotile structure that extends from the surface of most mammalian cell types and is critical for chemosensing and mechanosensing in a variety of tissues including carti...
The more we know, the more we have to discover: an exciting future for understanding cilia and ciliopathies [0.03%]
我们所知越多，要发现的东西也越多：了解纤毛和纤毛病理学的令人激动的未来
Alexandre Benmerah,Bénédicte Durand,Rachel H Giles et al.
Alexandre Benmerah et al.
The Cilia 2014 conference was organised by four European networks: the Ciliopathy Alliance, the Groupement de Recherche CIL, the Nordic Cilia and Centrosome Network and the EU FP7 programme SYSCILIA. More than 400 delegates from 27 countrie...
Calcium sensors of ciliary outer arm dynein: functions and phylogenetic considerations for eukaryotic evolution [0.03%]
cilium外臂动力蛋白的钙离子感受器：功能及对真核生物演化的系统发生学考量
Kazuo Inaba
Kazuo Inaba
The motility of eukaryotic cilia and flagella is modulated in response to several extracellular stimuli. Ca(2+) is the most critical intracellular factor for these changes in motility, directly acting on the axonemes and altering flagellar ...