A novel ICK mutation causes ciliary disruption and lethal endocrine-cerebro-osteodysplasia syndrome [0.03%]
新型ICK突变导致纤毛破坏和致命内分泌-脑骨发育不良综合征
Machteld M Oud,Carine Bonnard,Dorus A Mans et al.
Machteld M Oud et al.
Background: Endocrine-cerebro-osteodysplasia (ECO) syndrome [MIM:612651] caused by a recessive mutation (p.R272Q) in Intestinal cell kinase (ICK) shows significant clinical overlap with ciliary disorders. Similarities are...
Lillian K Fritz-Laylin,Chandler Fulton
Lillian K Fritz-Laylin
The amoeboflagellate Naegleria was one of the first organisms in which de novo basal body/centriole assembly was documented. When in its flagellate form, this single-celled protist has two flagella that are templated by two basal bodies. Ea...
Basal bodies across eukaryotes series: basal bodies in the freshwater planarian Schmidtea mediterranea [0.03%]
后生动物的基体系列：淡水_planarian_Schmidtea_mediterranea_中的基体
Juliette Azimzadeh,Cyril Basquin
Juliette Azimzadeh
The freshwater planarian Schmidtea mediterranea has recently emerged as a valuable model system to study basal bodies (BBs) and cilia. Planarians are free-living flatworms that use cilia beating at the surface of their ventral epidermis for...
Human basal body basics [0.03%]
人体基体基本知识
Anastassiia Vertii,Hui-Fang Hung,Heidi Hehnly et al.
Anastassiia Vertii et al.
In human cells, the basal body (BB) core comprises a ninefold microtubule-triplet cylindrical structure. Distal and subdistal appendages are located at the distal end of BB, where they play indispensable roles in cilium formation and functi...
Paul Guichard,Pierre Gönczy
Paul Guichard
Trichonympha is a symbiotic flagellate of many species of termites and of the wood-feeding cockroach. Remarkably, this unicellular organism harbors up to over ten thousand flagella on its surface, which serve to propel it through the viscou...
Measuring the primary cilium length: improved method for unbiased high-throughput analysis [0.03%]
一种改进的原初纤毛长度测量方法：无偏差高通量分析法
Anneloes Dummer,Christian Poelma,Marco C DeRuiter et al.
Anneloes Dummer et al.
Background: Primary cilia are cellular protrusions involved in mechanic and chemical sensing on almost all cells of our body. Important signaling pathways, including Hedgehog, TGFβ, and Ca(2+), are linked to cilia and/or...
Anne-Marie Tassin,Michel Lemullois,Anne Aubusson-Fleury
Anne-Marie Tassin
Paramecium is a free-living unicellular organism, easy to cultivate, featuring ca. 4000 motile cilia emanating from longitudinal rows of basal bodies anchored in the plasma membrane. The basal body circumferential polarity is marked by the ...
Basal body structure and cell cycle-dependent biogenesis in Trypanosoma brucei [0.03%]
布雷菲南特内布雷亚ensis基体结构与细胞周期依赖性发生学说研究
Sue Vaughan,Keith Gull
Sue Vaughan
Basal bodies are microtubule-based organelles that assemble cilia and flagella, which are critical for motility and sensory functions in all major eukaryotic lineages. The core structure of the basal body is highly conserved, but there is v...
Basal body structure and composition in the apicomplexans Toxoplasma and Plasmodium [0.03%]
托氏子孢子虫和疟疾原生动物顶体基体的结构与组成
Maria E Francia,Jean-Francois Dubremetz,Naomi S Morrissette
Maria E Francia
The phylum Apicomplexa encompasses numerous important human and animal disease-causing parasites, including the Plasmodium species, and Toxoplasma gondii, causative agents of malaria and toxoplasmosis, respectively. Apicomplexans proliferat...
Muqing Cao,Qing Zhong
Muqing Cao
Cancer cells are distinguished from normal cells by increased proliferation and metabolism, loss of polarity control, and the potential to invade other tissues of the body. As hubs of signaling transduction, primary cilia have been linked t...