Inna V Nechipurenko,Piali Sengupta
Inna V Nechipurenko
The free-living nematode, Caenorhabditis elegans, is a widely used genetic model organism for investigations into centriole and cilia biology. Only sensory neurons are ciliated in C. elegans; morphologically diverse cilia in these neurons a...
Tristan D McClure-Begley,Michael W Klymkowsky
Tristan D McClure-Begley
Cilia appear to be derived, evolutionarily, from structures present in the ancestral (pre-ciliary) eukaryote, such as microtubule-based vesicle trafficking and chromosome segregation systems. Experimental observations suggest that the cilia...
Mutations in IFT-A satellite core component genes IFT43 and IFT121 produce short rib polydactyly syndrome with distinctive campomelia [0.03%]
IFT-A卫星核心组件基因IFT43和IFT121突变产生具有特异性营挛症的短肋多指综合征
Ivan Duran,S Paige Taylor,Wenjuan Zhang et al.
Ivan Duran et al.
Background: Skeletal ciliopathies comprise a spectrum of ciliary malfunction disorders that have a profound effect on the skeleton. Most common among these disorders is short rib polydactyly syndrome (SRPS), a recessively...
Basal body positioning and anchoring in the multiciliated cell Paramecium tetraurelia: roles of OFD1 and VFL3 [0.03%]
OFD1和VFL3在多鞭毛生物Paramecium tetraurelia基体定位及锚定中的作用
Hakim Bengueddach,Michel Lemullois,Anne Aubusson-Fleury et al.
Hakim Bengueddach et al.
Background: The development of a ciliary axoneme requires the correct docking of the basal body at cytoplasmic vesicles or plasma membrane. In the multiciliated cell Paramecium, three conserved proteins, FOR20, Centrin 2,...
Fixation methods can differentially affect ciliary protein immunolabeling [0.03%]
固定的手段会影响 cilium 蛋白的免疫标记结果
Kiet Hua,Russell J Ferland
Kiet Hua
Background: Primary cilia are immotile, microtubule-based organelles present on most cells. Defects in primary cilia presence/function result in a category of developmental diseases referred to as ciliopathies. As the cil...
Zarko Manojlovic,Ryan Earwood,Akiko Kato et al.
Zarko Manojlovic et al.
Background: La-related protein 6 (LARP6) is an evolutionally conserved RNA-binding protein. Vertebrate LARP6 binds the 5' stem-loop found in mRNAs encoding type I collagen to regulate their translation, but other target m...
Patient-specific three-dimensional explant spheroids derived from human nasal airway epithelium: a simple methodological approach for ex vivo studies of primary ciliary dyskinesia [0.03%]
基于人鼻气道上皮的患者特异性三维原代球状体培养：一种针对原发性纤毛运动障碍的简单体外研究方法
June Kehlet Marthin,Elizabeth Munkebjerg Stevens,Lars Allan Larsen et al.
June Kehlet Marthin et al.
Background: Three-dimensional explant spheroid formation is an ex vivo technique previously used in studies of airway epithelial ion and water transport. Explanted cells and sheets of nasal epithelium form fully different...
Megan S Kane,Mariska Davids,Michelle R Bond et al.
Megan S Kane et al.
Background: The discovery of disease pathogenesis requires systematic agnostic screening of multiple homeostatic processes that may become deregulated. We illustrate this principle in the evaluation and diagnosis of a 5-y...
CILIA: before and after [0.03%]
cilial：术前术后照片
Peter Satir
Peter Satir
This is a history of cilia research before and after the discovery of intraflagellar transport (IFT) and the link between primary cilia ciliogenesis and polycystic kidney disease (PKD). Before IFT, ca. the beginning of the new millennium, a...
Greenfield Sluder
Greenfield Sluder
Centriole structure and function in the sea urchin zygote parallel those in mammalian somatic cells. Here, I briefly introduce the properties and attributes of the sea urchin system that make it an attractive platform for the study of centr...