The mitotic spindle protein SPAG5/Astrin connects to the Usher protein network postmitotically [0.03%]
丝分裂蛋白SPAG5/Astrin在间期连接到Usher蛋白网络
Ferry Fj Kersten,Erwin van Wijk,Lisette Hetterschijt et al.
Ferry Fj Kersten et al.
Background: Mutations in the gene for Usher syndrome 2A (USH2A) are causative for non-syndromic retinitis pigmentosa and Usher syndrome, a condition that is the most common cause of combined deaf-blindness. To gain insigh...
Sarah N Bay,Tamara Caspary
Sarah N Bay
Primary cilia are present on almost all vertebrate cells, and they have diverse functions in distinct tissues. Cilia are important for sensation in multiple capacities in contexts as different as the retina, kidney, and inner ear. In additi...
Founder mutations and genotype-phenotype correlations in Meckel-Gruber syndrome and associated ciliopathies [0.03%]
Meckel-Gruber综合征及相关纤毛病的致病突变及其基因型表型相关性分析
Katarzyna Szymanska,Ian Berry,Clare V Logan et al.
Katarzyna Szymanska et al.
Background: Meckel-Gruber syndrome (MKS) is an autosomal recessive lethal condition that is a ciliopathy. MKS has marked phenotypic variability and genetic heterogeneity, with mutations in nine genes identified as causati...
Megan Smith Valentine,Anbazhagan Rajendran,Junji Yano et al.
Megan Smith Valentine et al.
Background: Changes in genes coding for ciliary proteins contribute to complex human syndromes called ciliopathies, such as Bardet-Biedl Syndrome (BBS). We used the model organism Paramecium to focus on ciliary ion channe...
Dorte L Egeberg,Mette Lethan,Robert Manguso et al.
Dorte L Egeberg et al.
Background: Ovarian cancer is the fourth leading cause of cancer-related deaths among women in Denmark, largely due to the advanced stage at diagnosis in most patients. Approximately 90% of ovarian cancers originate from ...
ciliaFA: a research tool for automated, high-throughput measurement of ciliary beat frequency using freely available software [0.03%]
基于免费软件的用于自动化高通量测量纤毛摆动频率的研究工具
Claire M Smith,Jana Djakow,Robert C Free et al.
Claire M Smith et al.
Background: Analysis of ciliary function for assessment of patients suspected of primary ciliary dyskinesia (PCD) and for research studies of respiratory and ependymal cilia requires assessment of both ciliary beat patter...
Ciliary and non-ciliary expression and function of PACRG during vertebrate development [0.03%]
PACRG在脊椎动物发育过程中的视神经纤毛和非纤毛表达与功能研究
Thomas Thumberger,Cathrin Hagenlocher,Matthias Tisler et al.
Thomas Thumberger et al.
Background: Park2-co-regulated gene (PACRG) is evolutionarily highly conserved from green algae to mammals. In Chlamydomonas and trypanosomes, the PACRG protein associates with flagella. Loss of PACRG results in shortened...
Saikat Mukhopadhyay,Peter K Jackson
Saikat Mukhopadhyay
Primary cilia have been previously linked to the central regulation of satiety. The tubby mouse is characterized by maturity-onset obesity and blindness. A recent paper demonstrates molecular defects in trafficking of ciliary GPCRs in the c...
The effect of halothane and pentobarbital sodium on brain ependymal cilia [0.03%]
氟烷和戊巴比妥钠对脑室脉络丛纤毛活动的影响
Chris O&#x;Callaghan,Kulvinder Sikand
Chris O&#x;Callaghan
Background: The effect of anesthetic agents on ependymal ciliary function is unknown. The aim of this study was to determine the effect of halothane and pentobarbital sodium on brain ependymal ciliary function. ...
Centrosomes in the zebrafish (Danio rerio): a review including the related basal body [0.03%]
斑马鱼中心体的研究进展及基体相关研究概述
Charles A Lessman
Charles A Lessman
Ever since Edouard Van Beneden and Theodor Boveri first formally described the centrosome in the late 1800s, it has captivated cell biologists. The name clearly indicated its central importance to cell functioning, even to these early inves...