N-terminal oligomerization drives HDAC4 nuclear condensation and neurodevelopmental dysfunction in Drosophila [0.03%]
果蝇HDAC4的N端寡聚化驱动其核凝聚及神经发育障碍
Hannah R Hawley,Andrew J Sutherland-Smith,Matthew S Savoian et al.
Hannah R Hawley et al.
Histone deacetylase four (HDAC4) undergoes dynamic nucleocytoplasmic shuttling, a process critical for regulating its activity. However, aberrant nuclear accumulation of HDAC4 is associated with both neurodevelopmental and neurodegenerative...
Autophagy: a novel target in order to overcome drug resistance in pancreatic adenocarcinoma [0.03%]
自噬：克服胰腺癌耐药性的新靶点
Bahareh Shateri Amiri,Mehrasa Naserranjbar,Fatemeh Aliabadi et al.
Bahareh Shateri Amiri et al.
Typically, unchecked pancreatic cell proliferation results in the development of pancreatic cancer, which has the potential to spread to other bodily organs. About 90% of instances of pancreatic cancer are pancreatic adenocarcinomas. About ...
Keratinocyte self-renewal and differentiation is dictated by extrinsic signals from dermal extracellular matrices [0.03%]
角质形成细胞的自我更新和分化受真皮细胞外基质的外部信号调控
Chee Wai Wong,Catherine F LeGrand,Beverley F Kinnear et al.
Chee Wai Wong et al.
Fetal skin has an intrinsic regenerative capability to restore an injured site's architecture and functionality. This is preserved until the third trimester, when wound healing transitions to a scarring reparative response. This change coin...
The evolutionary entanglement of flipons with zinc fingers and retroelements has engendered a large family of Z-DNA and G-quadruplex binding proteins [0.03%]
.flipon与锌指和逆转座子的进化纠缠产生了大量结合Z-DNA和G-四链体的蛋白质家族
Alan Herbert
Alan Herbert
Sequences called flipons can adopt discrete, alternative nucleic acid conformations, such as the left-handed Z-DNA and Z-RNA double helices (referred to collectively as ZNA), and the four-stranded RNA and DNA G-quadruplexes. Each flipon con...
Revealing the ultrastructure of live Candida albicans using stimulated emission depletion microscopy [0.03%]
利用受激发射损耗显微镜技术揭示活体白念珠菌的亚细胞结构
Katherine J Baxter,Liam Mark Rooney,Shannan Foylan et al.
Katherine J Baxter et al.
Candida albicans, a commensal fungal pathogen, is a leading cause of opportunistic infections in immunocompromised individuals. High-resolution imaging of its cellular architecture is essential for uncovering pathogenic mechanisms and ident...
FLP-15 modulates the amplitude of body-bends during locomotion in Caenorhabditis elegans [0.03%]
FLP-15通过调节运动过程中体弯曲幅度来调控秀丽隐杆线虫的运动模式
Umer Saleem Bhat,Sharanya H,Siju Surendran et al.
Umer Saleem Bhat et al.
Locomotion is essential for executing most behaviours. In Caenorhabditis elegans, efficient locomotion is exhibited as a result of the coordination of excitatory and inhibitory signals from the nervous system onto the body-wall muscles. Alt...
Prenatal alcohol exposure dysregulates the expression of clock genes and alters rhythmic behaviour in mice [0.03%]
宫内酒精暴露通过调节小鼠时钟基因的表达而改变其节律行为
Maria Reina-Campos,Ines Gallego-Landin,Mireia Medrano et al.
Maria Reina-Campos et al.
Foetal alcohol spectrum disorders (FASDs) refer to a range of adverse physical, behavioural and cognitive effects caused by perinatal alcohol exposure. While cognitive impairments are well documented, FASD has also been associated with slee...
HMGB1 and mitochondrial dysfunction: a double-edged sword in ageing [0.03%]
HMGB1与线粒体功能障碍：在衰老中的双刃剑效应
Maheen Wahid,Margaret Cunningham
Maheen Wahid
Ageing is an intricate and progressive decline across all biological systems, marked by various molecular and cellular processes termed as the hallmarks of ageing. One of the hallmarks is mitochondrial dysfunction, which is brought about th...
Louna Fruchard,Claudia Salinas,Andre Carvalho et al.
Louna Fruchard et al.
Transfer RNAs (tRNAs) and their modifications are central to bacterial translation and physiology, yet their roles in stress adaptation remain underexplored. While extensively studied in eukaryotes, and linked to diseases, bacterial tRNA mo...
Transcriptomic and metabolomic insights into light-mediated unicellular-to-multicellular transition in Dictyostelium discoideum [0.03%]
柄眼虫门 Discoteliophora dictyostelioida 中光照介导的单细胞向多细胞转变的转录组和代谢组学见解
Yuehui Tian,Huiru Liu,Shanshan Xu et al.
Yuehui Tian et al.
Dictyostelium discoideum is a social amoeba that transitions from unicellular to multicellular forms in response to environmental signals, making it an intriguing model for studying cell aggregation and differentiation. Although previous st...