Rui Resende Pinto,Raquel Ruivo,Josefin Stiller et al.
Rui Resende Pinto et al.
Exploring the evolution of gene networks associated with metabolic/energetic homeostasis can yield key insights into the adaptive landscapes governing the physiology of extant lineages. Here, we investigate a key hormonal module of energy m...
Verónica Martínez-Osorio,Uris Ros,Ana J García-Sáez
Verónica Martínez-Osorio
Necroptosis is a form of regulated cell death (RCD) that evolved as a defence against pathogenic infection. Unlike caspase-dependent RCD, necroptosis, in its canonical form, is driven by receptor-interacting protein kinase 1 and 3 (RIPK1 an...
Fucosyltransferase 8 facilitates EMT in glioblastoma cells through the remodelling of TGF-β receptor core fucosylation [0.03%]
转移性胶质母细胞瘤中TGF-β受体半乳糖基化的重塑促进上皮间充质转化
Bo Xu,Zhengrong Zhang,You Yu et al.
Bo Xu et al.
Fucosyltransferase 8 (FUT8), a glycosyltransferase responsible for core fucosylation, is overexpressed in numerous cancers and promotes many malignant processes such as cell proliferation, invasion and migration. Transforming growth factor-...
The interplay of epigenetic remodelling and transposon-mediated genomic instability in ageing and longevity [0.03%]
表观遗传重构与转座子介导的基因组不稳定性在衰老和长寿中的相互作用
Aaron J J Lemus,Eyael Tewelde,Rajyk Bhala et al.
Aaron J J Lemus et al.
Ageing and age-related diseases are the result of complex biological processes that progressively cause deterioration of cellular and tissue function. Among the key hallmarks of ageing are epigenetic alterations and genomic instability, bot...
Building a functional endoplasmic reticulum for proper cell growth and stress responses: a plant perspective [0.03%]
构建功能性内质网以促进细胞正常生长和胁迫响应——植物视角
Weina Wang,Huanquan Zheng
Weina Wang
The endoplasmic reticulum (ER) is an interconnected network of membrane-bound tubules and sheets stretching throughout the cytoplasm of all eukaryotic cells including plant cells. The ER is highly dynamic and undergoes constant remodelling....
Myosin heavy chain 10 dysregulation in infertile endometrial epithelial cells impairs adhesive capacity [0.03%]
肌球蛋白重链10在不孕子宫内膜上皮细胞中的调控紊乱影响其黏附能力
Michaela Sacco,Poppy Downing,Leilani L Santos et al.
Michaela Sacco et al.
Endometrial receptivity occurs during a limited time in the menstrual cycle called the 'window of implantation' (WOI) and is required for successful implantation. Endometrial luminal epithelial cells become adhesive to facilitate embryo att...
Pierce N Mullen,Beatrice Bowlby,Holly C Armstrong et al.
Pierce N Mullen et al.
The actions of animals provide a window into how their minds work. Recent advances in deep learning are providing powerful approaches to recognize patterns of animal movement from video recordings using markerless pose estimation models. Cu...
Mother cells can establish slow-growing lineages in clonal populations since their earliest division cycles [0.03%]
母细胞可以在其最早的分裂周期中在其克隆群体中建立缓慢生长的系谱
Irene Delgado-Román,María José García-Marcelo,Carmen Ruger-Herreros et al.
Irene Delgado-Román et al.
Clonal populations exhibit phenotypic variation despite being composed of genetically identical cells under the same environmental conditions. The proliferation rate also shows this heterogeneity, but the underlying mechanisms remain poorly...
Decoding 'Wntch': the intertwined Wnt and Notch pathways in development and disease [0.03%]
“Wntch”解码：发育和疾病中相互交织的Wnt和Notch通路
Fabio Turetti,Marek Dokoupil,Giovanna M Collu et al.
Fabio Turetti et al.
Multicellularity emerges from the ability of cells to undergo functional differentiation. One of the key mechanisms that enables this coordination is cellular signalling-a series of molecular interactions within or between cells that induce...
Tony Hunter
Tony Hunter