Transcriptome-wide identification and expression profiling of chemosensory genes in rice grasshopper Oxya intricata (Orthoptera: Acrididae) [0.03%]
水稻草螽(Oxya intricata)味觉和嗅觉基因的鉴定及表达分析
Ran Li,Chao Xue,Dongkai Liu et al.
Ran Li et al.
Chemosensory systems play an essential role in insect survival and reproduction, mediating behaviours such as host location, mating and oviposition. The rice grasshopper Oxya intricata is an important rice pest in Asia, yet the molecular ba...
FRET-based fluorescent sensors for cytosolic and mitochondrial Ca2+ imaging in Drosophila melanogaster [0.03%]
用于斑翅果蝇细胞质和线粒体钙成像的FRET型荧光传感器
Manuela Santalla,Sonia Sonda,Ambra Bertocco et al.
Manuela Santalla et al.
Ca2+ imaging in the living tissues of experimental animals currently presents limitations due to motion artefacts, variable expression levels and the low basal fluorescence of available probes. These issues are even more troublesome when pe...
Mingshu Liang,Magdalena Zernicka-Goetz,Adiyant Lamba et al.
Mingshu Liang et al.
The existence of sex differences in human pre-implantation development remains an open question, with previous attempts based on human observations yielding inconclusive results. In this study, we combined manual annotation and deep learnin...
Histidine and tyrosine residues are targets for SIRT6 ADP-ribosylation activity [0.03%]
丝氨酸/精氨琥珀酸特异性核酸内切酶SIRT6的ADP核糖基化作用位点是他束和酪氨酸残基
Johannes Gregor Matthias Rack,Evgeniia Prokhorova,Raffaella Lauro et al.
Johannes Gregor Matthias Rack et al.
SIRT6, a highly conserved member of the sirtuin family, plays a critical role in diverse cellular processes, including gene regulation, DNA damage response and maintaining nuclear lamina integrity. These functions are essential in contexts ...
Looks can be deceiving: discordances in phylogeny and morphology within loricate choanoflagellates [0.03%]
形态与分子系统发育的不一致性的漏网之鱼——带壳的Choanoflagellatea类群
Alex Gàlvez-Morante,Florentine U Rutaganira,Brian Palenik et al.
Alex Gàlvez-Morante et al.
Choanoflagellates are heterotrophic holozoans that are classified into two groups based on their morphology: loricates, which possess silica-based extracellular structures, and craspedids, which do not. Loricate choanoflagellate taxonomy ha...
Extracellular spike waveform analysis reveals cell type-specific changes in the superior colliculus of fragile X mice [0.03%]
外突触动作电位波形分析揭示了脆性X综合征小鼠上丘的细胞类型特异性变化
Gourav Sharma,Ashley L Russell,Karen G Dixon et al.
Gourav Sharma et al.
Sensory processing deficits are common in neurodevelopmental disorders (NDDs); however, we lack a full understanding of the circuits impacted. The superior colliculus (SC) is a sensorimotor region that directs complex behaviours, which rece...
Anti-apoptotic BCL-2 binds to all three IP3R isoforms, thereby limiting the Ca2+-flux properties of IP3R homo-tetramers [0.03%]
抗凋亡蛋白BCL-2与IP3R三种异构体结合，从而限制了IP3R同源四聚体的钙离子通量性质
Ian de Ridder,Claire Cauwelier,Larry E Wagner Ii et al.
Ian de Ridder et al.
Anti-apoptotic B-cell lymphoma 2 (BCL-2) controls inositol 1,4,5-trisphosphate receptor (IP3R)-mediated Ca²+ signalling. As cells typically express all three IP3R isoforms in variable abundances that assemble in hetero-tetrameric channels,...
20-hydroxyecdysone regulated exosomal transport of mulberry urease drives nitrogen recycling and silkworm development [0.03%]
桑白榆脲酶的蜕皮甾醇调控的囊泡运输驱动氮循环和家蚕发育
Mingbo Li,Jiubo Liang,Hulin Lu et al.
Mingbo Li et al.
The recycling of urea nitrogenous by urease presents a valuable approach for optimizing nitrogen utilization in organisms with limited nitrogen resources. In silkworms, haemolymph urea concentration correlates with urease activity, and the ...
Heat shock protein 90 as a vital signalling hub in Schistosoma mansoni: a master regulator of stem cell proliferation, development and survival [0.03%]
热休克蛋白90作为调控干细胞增殖、发育和存活的施氏叶虫信号转导中心.master调节因子
Nancy Adamma Aguoru,Ruth Suzanne Kirk,Anthony John Walker
Nancy Adamma Aguoru
Heat shock protein 90s (HSP90s) are molecular chaperones often produced by cells in response to hostile conditions. Here, we characterized the importance of HSP90 to growth/development and survival of the blood fluke Schistosoma mansoni, fo...
Transmembrane proteins in cancer: insights from mechanism to clinical impact [0.03%]
癌症中的跨膜蛋白：从机制到临床影响的见解
Chih-Wen Shu,Chia-Hsuan Chang,Hsing-Hsiang Wang et al.
Chih-Wen Shu et al.
Transmembrane proteins (TMEMs) constitute a large family of proteins that span biological membranes and are distributed across various cellular organelles, playing key roles in maintaining cellular homeostasis. Increasing evidence has revea...