Non-cell-autonomous regulation of testicular stem cell niche homeostasis by the 20S proteasome core particle through cell adhesion and cyclin proteins [0.03%]
去泛素化酶USP22通过调控细胞粘附和周期蛋白维持雄性生殖干细胞微生态平衡
Jiaxin Li,Chenyu Wang,Weiyi Qian et al.
Jiaxin Li et al.
The Drosophila stem cell niche harbours two principal stem cell populations: germline stem cells (GSCs) and cyst stem cells (CySCs), whose self-renewal and differentiation are stringently governed by niche-derived regulatory factors. Nevert...
Mechanical bone loading effects on morphology and mechanobiology in the coronal suture of Crouzon mice [0.03%]
机械骨负荷对Crouzon小鼠冠状缝形态和力学生物学的影响
Miranda Steacy,Marius Didziokas,Tengyang Qiu et al.
Miranda Steacy et al.
Craniosynostosis is a congenital condition characterized by the premature fusion of the craniofacial sutures. The Crouzon mouse (Fgfr2cC342Y/+) is a well-established model of this condition which shows premature fusion of the coronal suture...
Epigenomic and transcriptomic analyses reveal cnidocyte specialization in a sea anemone [0.03%]
表观基因组和转录组分析揭示了海葵刺细胞的特化现象
Itamar Kozlovski,Adrian Jaimes-Becerra,Daria Aleshkina et al.
Itamar Kozlovski et al.
Cnidarians, including corals, hydras, jellyfish and sea anemones, possess specialized stinging cells called cnidocytes that function in prey capture and defense. These cells represent a striking evolutionary innovation and produce distinct ...
Pre-cheliceral region patterning in a spider provides new insights into the development and evolution of arthropod neurosecretory centres [0.03%]
蜘蛛前胸节区图案化为节肢动物神经分泌中心的发育和进化提供了新见解
Amber Harper,Lauren Sumner-Rooney,Ralf Janssen et al.
Amber Harper et al.
Comparing head development among arthropods has helped identify ancestral aspects of brain patterning and structure in animals more generally. Most understanding of arthropod head patterning has been learned from insects and the myriapod St...
Autophagy in the arms race: how pathogen effectors rewire immunity in plants [0.03%]
植物与病原菌的军备竞赛中的自噬作用：效应蛋白如何重塑免疫系统
Enoch Lok Him Yuen,Tolga O Bozkurt
Enoch Lok Him Yuen
Autophagy is an evolutionarily conserved recycling process that underpins cellular homeostasis and stress resilience in eukaryotes. In the context of plant-pathogen interactions, autophagy has emerged as a key regulatory hub linking immunit...
The biology and pathophysiology of the proatherogenic metalloprotease ADAMTS7 [0.03%]
金属蛋白酶ADAMTS7的生物学和病理生理学（与动脉粥样硬化相关）
Shiwali Goyal,James Muniu,Mohd Akbar Bhat et al.
Shiwali Goyal et al.
The ADAMTS (a disintegrin and metalloproteinase with thrombospondin type-1 motifs) metalloprotease family comprises 19 members, and they play critical roles in development, angiogenesis and coagulation. These enzymes are also pivotal in the...
Exploring the role of stress sensitivity in memory formation: why do some animals learn while others do not? Lessons from Lymnaea stagnalis [0.03%]
应激敏感性在记忆形成中的作用探索：为什么一些动物会学习而另一些不会？来自Lymnaea stagnalis的启示
Veronica Rivi,Kate Yakubets,Grace Pele et al.
Veronica Rivi et al.
The ability to learn and form memory is critical for survival, yet even genetically similar individuals can vary considerably in their cognitive performance. Using the pond snail Lymnaea stagnalis, we investigated how individual sensitivity...
Know thyself [0.03%]
认识你自己
Jonathon Pines
Jonathon Pines
STIM1 and endoplasmic reticulum-plasma membrane contact sites oscillate independently of calcium-induced calcium release [0.03%]
STIM1及内质网-细胞膜接触位点的振荡独立于钙诱导的钙释放发生
Ding Xiong,Cheesan Tong,Suet Yin Sarah Fung et al.
Ding Xiong et al.
Calcium (Ca²+) release from intracellular stores, Ca²+ entry across the plasma membrane and their coordination via store-operated Ca²+ entry (SOCE) are critical for receptor-activated Ca²+ oscillations. However, the precise mechanism of...
Konstantinos Stamatiou,Lorena Ligammari,Malki Bothota et al.
Konstantinos Stamatiou et al.
Cellular myelocytomatosis oncogene (MYC) transcription factors are encoded by a family of genes that include the prototype member MYC, MYCN and MYCL, and most human cancers display expression alterations of MYC genes. MYC is regulated at mu...