The periosteum as an endocrine organ: historical foundations and new insights [0.03%]
骨膜作为内分泌器官：历史基础与新见解
Madhura Nijsure,Clifford J Rosen
Madhura Nijsure
Anatomists have recognized the periosteum as essential for bone growth and repair, and yet its broader physiological roles have remained underappreciated. Emerging evidence now positions the periosteum not only as a structural membrane, but...
NudC moonlights in ribosome biogenesis and homeostasis in polyploid cells of Drosophila melanogaster [0.03%]
NudC 在果蝇多倍体细胞中参与核糖体生物发生和稳态调控
Duoduo Shi,Yuko Shimada-Niwa,Naoki Okamoto et al.
Duoduo Shi et al.
Ribosomes, the cellular machinery responsible for protein synthesis, are fundamental across all kingdoms of life. Disruption of ribosome biogenesis (RiBi) can cause severe ribosomopathies, underscoring the need for precise regulatory mechan...
Pan-resistome and genomic plasticity analysis of antibiotic resistance in Aeromonas: new vaccine targets for A. caviae, A. veronii and A. hydrophila through reverse vaccinology [0.03%]
肠杆菌属泛耐药组和基因组可塑性分析：通过反向疫苗学寻找凯氏味杆菌、欧文氏味杆菌及水型味杆菌的新型疫苗靶点
Caio Luigi Antunes Moura Tristão,Andrei Giacchetto Felice,Ligia Carolina da Silva Prado et al.
Caio Luigi Antunes Moura Tristão et al.
Aeromonas species are globally significant pathogens. However, the mechanisms driving their antimicrobial resistance patterns remain unclear. This study addresses the spread of resistance genes in the Aeromonas genus through a large-scale g...
Shaping the microvascular network: insights into skeletal muscle angiogenesis [0.03%]
塑造微血管网络：骨骼肌血管生成的见解
Thomas Gustafsson,Emmanuel Nwadozi,Andrea Tryfonos et al.
Thomas Gustafsson et al.
Angiogenesis, the formation of new blood vessels from pre-existing vasculature, is a complex and tightly regulated biological process that plays a fundamental role in both physiological and pathological tissue remodeling by facilitating the...
Investigating how changes in the levels of kinesins impact neuronal health in Drosophila and human iPSC-derived neurons AD model [0.03%]
探究果蝇和人诱导多能干细胞来源的神经元AD模型中动力蛋白水平变化对神经健康的影响
Deepthy Francis,Francesco Paonessa,Victoria L Hewitt et al.
Deepthy Francis et al.
Alzheimer's disease (AD) is the leading cause of dementia and the most common neurodegenerative disorder. Understanding the molecular pathology of AD may help identify new ways to reduce neuronal damage. In the past decades, Drosophila has ...
Macrophages warrant Mauthner cell axon regrowth by preventing late-stage hyperglycemia in zebrafish [0.03%]
巨噬细胞通过防止斑马鱼晚期内糖基化从而促使Mauthner细胞轴突再生
Jing Bai,Siting Lai,Yubei Huang et al.
Jing Bai et al.
Axonal regeneration in the central nervous system is imperative for functional restoration following spinal cord injury (SCI). Myeloid cells are key regulators of axonal regeneration, yet their roles are not fully revealed. SCI perturbs glu...
Is the alpha-amylase paralogue Amyrel dispensable in Drosophila melanogaster? [0.03%]
果蝇α-淀粉酶旁系同源物Amyrel不可或缺吗？
Jean-Luc Da Lage,Magalie Bonneau,Céline Moreno et al.
Jean-Luc Da Lage et al.
Divergent duplicated gene copies are considered to get new or variant function or regulation through sub- or neofunctionalization. In Drosophila and other flies (Muscomorpha), the alpha-amylase paralogue Amyrel is known to have peculiar enz...
Oocyst: knowns and unknowns about the lengthiest life stage of the malaria parasite [0.03%]
残留在体内的疟原虫生命阶段：已知与未知
Alexander J Bailey,Dina Vlachou,George K Christophides
Alexander J Bailey
The oocyst is the longest life stage of Plasmodium, the causative agent of malaria, one of the most persistent and devastating infectious diseases of humankind. Following ingestion during blood feeding, parasites reproduce sexually and trav...
Unveiling karyoskeletal dynamics in chromatin organization and gene regulation in haematopoietic cell physiology and pathology [0.03%]
揭示核骨架动力学在造血细胞生理和病理的染色质组织和基因调控中的作用
Mohd Kamran,Nicolas Nassar,Jose A Cancelas
Mohd Kamran
Chromatin organization and gene regulation are essential for maintaining homeostatic haematopoiesis, the tightly regulated process by which haematopoietic stem and progenitor cells generate diverse blood lineages. Growing evidence identifie...
tRNA modification landscapes in streptococci: shared losses and clade-specific adaptations [0.03%]
链球菌的tRNA修饰图谱：共有的丧失和支系特异性的适应性演化
Ho-Ching Tiffany Tsui,Chi-Kong Chan,Yifeng Yuan et al.
Ho-Ching Tiffany Tsui et al.
tRNA modifications are central to bacterial translational control. Here, we integrated genetics, mass spectrometry, epitranscriptomics and comparative genomics to map the tRNA modification genes of the Gram-positive pathogens Streptococcus ...