Synaptic dysfunction in neurodegenerative and neurodevelopmental diseases: an overview of induced pluripotent stem-cell-based disease models [0.03%]
神经退行性和神经发育性疾病中突触功能障碍：基于诱导多能干细胞的疾病模型概述
Era Taoufik,Georgia Kouroupi,Ourania Zygogianni et al.
Era Taoufik et al.
Synaptic dysfunction in CNS disorders is the outcome of perturbations in physiological synapse structure and function, and can be either the cause or the consequence in specific pathologies. Accumulating data in the field of neuropsychiatri...
Anna Ovcharenko,Andrea Rentmeister
Anna Ovcharenko
RNA methylations play a significant regulatory role in diverse biological processes. Although the transcriptome-wide discovery of unknown RNA methylation sites is essential to elucidate their function, the development of a bigger variety of...
Structural insights into the functional diversity of the CDK-cyclin family [0.03%]
CDK-细胞周期蛋白家族功能多样性的结构见解
Daniel J Wood,Jane A Endicott
Daniel J Wood
Since their characterization as conserved modules that regulate progression through the eukaryotic cell cycle, cyclin-dependent protein kinases (CDKs) in higher eukaryotic cells are now also emerging as significant regulators of transcripti...
Correction to 'Shape, form, function and Leishmania pathogenicity: from textbook descriptions to biological understanding' [0.03%]
关于“利什曼原虫致病性的形状、形式、功能：从教科书描述到生物学理解”的更正
Jack Sunter,Keith Gull
Jack Sunter
Published Erratum
Open biology. 2018 Aug;8(8):180134. DOI:10.1098/rsob.180134 2018
A unified view of spatio-temporal control of mitotic entry: Polo kinase as the key [0.03%]
polo激酶是细胞周期中调控有丝分裂进程的关键因素
Lionel Pintard,Vincent Archambault
Lionel Pintard
The Polo kinase is an essential regulator of cell division. Its ability to regulate multiple events at distinct subcellular locations and times during mitosis is remarkable. In the last few years, a much clearer mechanistic understanding of...
Abhay P S Rathore,Ashley L St John
Abhay P S Rathore
Dengue virus (DENV) causes infection in humans and current estimates place 40% of the world population at risk for contracting disease. There are four DENV serotypes that induce a febrile illness, which can develop into a severe and life-th...
Spatial organization of different sigma factor activities and c-di-GMP signalling within the three-dimensional landscape of a bacterial biofilm [0.03%]
细菌生物被膜三维景观中不同σ因子活性和c-di-GMP信号的空间组织
Gisela Klauck,Diego O Serra,Alexandra Possling et al.
Gisela Klauck et al.
Bacterial biofilms are large aggregates of cells embedded in an extracellular matrix of self-produced polymers. In macrocolony biofilms of Escherichia coli, this matrix is generated in the upper biofilm layer only and shows a surprisingly c...
Leader of the SAC: molecular mechanisms of Mps1/TTK regulation in mitosis [0.03%]
SAC组长：有丝分裂中Mps1/TTK的调节机制分子机理研究
Spyridon T Pachis,Geert J P L Kops
Spyridon T Pachis
Discovered in 1991 in a screen for genes involved in spindle pole body duplication, the monopolar spindle 1 (Mps1) kinase has since claimed a central role in processes that ensure error-free chromosome segregation. As a result, Mps1 kinase ...
J R de Ruiter,L F A Wessels,J Jonkers
J R de Ruiter
Cancer is a complex disease in which cells progressively accumulate mutations disrupting their cellular processes. A fraction of these mutations drive tumourigenesis by affecting oncogenes or tumour suppressor genes, but many mutations are ...
Conserved temporal ordering of promoter activation implicates common mechanisms governing the immediate early response across cell types and stimuli [0.03%]
启动子激活的保守时间顺序表明，在不同类型和刺激下即时早期反应共同作用的机制
Annalaura Vacca,Masayoshi Itoh,Hideya Kawaji et al.
Annalaura Vacca et al.
The promoters of immediate early genes (IEGs) are rapidly activated in response to an external stimulus. These genes, also known as primary response genes, have been identified in a range of cell types, under diverse extracellular signals a...