Functional disruption of oxytocin projections participates atypical social and anxiety-like behaviours in BTBR mouse model of autism [0.03%]
oxytocin投射的功能障碍参与自闭症小鼠模型BTBR中非典型性社交和类似焦虑的行为
Yuki Higuchi,Akihiko Ozawa,Ryuki Kobayashi et al.
Yuki Higuchi et al.
Oxytocin (OXT) neurons in the paraventricular nucleus of the hypothalamus (PVN), which send projections to the medial amygdala (MeA) and the bed nucleus of the stria terminalis (BnST), are implicated in regulation of prosocial-emotional beh...
Nathaniel A Sweet,Chi-Kuo Hu
Nathaniel A Sweet
Diapause is a fascinating form of biological dormancy that is employed by a broad array of animals as a survival strategy to endure adverse environmental conditions. This unique dormant state can suspend organismal development until a more ...
Systemic analyses show that the biosynthesis and spatial distribution of fatty acids, triglycerides and lipids differed in male and female mice and humans [0.03%]
系统分析显示小鼠和人类的脂肪酸、甘油三酯和脂质的生物合成及其空间分布因性别而异
Samuel Furse,Samuel Virtue,Isabel Huang-Doran et al.
Samuel Furse et al.
Recent work has shown that the prevalence and character of metabolic diseases differs between male and female mammals. This strongly suggests that the control mechanisms that govern, for example lipid metabolism, differ between the sexes. I...
Developmental remodelling of Drosophila flight muscle sarcomeres: a scaled myofilament lattice model based on multiscale morphometrics [0.03%]
基于跨尺度形态测量的果蝇飞行肌 sarcomere 重塑简化模型：以细肌丝晶格为基础
Péter Görög,Tibor Novák,Tamás F Polgár et al.
Péter Görög et al.
The indirect flight muscle is a widely used model for studying sarcomere structure and muscle development due to its extremely regular architecture. Nevertheless, precise measurement of the basic sarcomeric parameters remains a challenge ev...
Mitochondrial-derived gene expression in hibernation: tissue-specific responses in the thirteen-lined ground squirrel [0.03%]
地熊鼠冬眠相关的线粒体基因表达：十三条纹地熊鼠组织特异性响应
Sarah Viola Emser,Eva Millesi
Sarah Viola Emser
Hibernation is a remarkable physiological adaptation in many mammals, characterized by prolonged torpor and profound metabolic suppression. Despite its importance, the molecular mechanisms regulating mitochondrial-derived gene expression du...
Selective loss of ATP carriers in favour of SLC25A43 orthologues in metamonad mitochondria adapted to anaerobiosis [0.03%]
甲烷原虫属线粒体适应厌氧性时ATP载体选择性丧失而SLC25A43同源物得以保留
Natalia Janowicz,Vít Dohnálek,Justyna Zítek et al.
Natalia Janowicz et al.
Metamonada is a eukaryotic supergroup of free-living and parasitic anaerobic protists. Their characteristic feature is the presence of highly reduced mitochondria that have lost the ability to produce ATP by oxidative phosphorylation and in...
Transcriptional regulation as a dose-dependent process: insights from transcription factor tuning [0.03%]
剂量依赖型转录调控作用的新观点：来自转录因子微调的启示
Gemma Noviello
Gemma Noviello
Several biological processes, including transcriptional regulation by transcription factors (TFs), are dose-dependent. At the mathematical level, dose-dependent processes can be modelled by fitting dose-response curves, for istance, employi...
Anthony H Tsang,Liubou Samson,Clemence Blouet
Anthony H Tsang
Amino acids are essential for normal physiological functions, and disruptions in their circulating concentrations are implicated in the pathophysiology of various diseases. Therefore, understanding the mechanisms that regulate circulating a...
Kirsty Tinto,Margaret Cunningham,Robin Plevin
Kirsty Tinto
IκB kinase alpha (IKKα) is a serine/threonine kinase originally known for its role in nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signalling, which integrates inflammatory processes and cancer. IKKα can functi...
Discovery of unique mitotic mechanisms in Paradiplonema papillatum [0.03%]
柄盘虫（Paradiplonema papillatum）独特的有丝分裂机制的发现
Bungo Akiyoshi,Drahomíra Faktorová,Julius Lukeš
Bungo Akiyoshi
Diplonemids are highly diverse and abundant marine plankton with significant ecological importance. However, little is known about their biology, even in the model diplonemid Paradiplonema papillatum whose genome sequence is available. Exam...