MRG15 decline in aged/injured MuSCs hinders regeneration via differentiation defects [0.03%]
MRG15缺失通过分化缺陷阻碍衰老和受伤肌肉干细胞的再生功能
Zhuoyang Li,Mei Ma,Siyi Shen et al.
Zhuoyang Li et al.
Skeletal muscle aging is characterized by a functional decline in muscle stem cells (MuSCs), yet the key regulatory mechanisms driving this deterioration remain poorly understood. By integrating transcriptomic profiles from aged MuSCs with ...
Dual recombinase-mediated endothelial cell-specific lineage tracing and ablation [0.03%]
双重组酶介导的内皮细胞特异性谱系示踪和消融
Jie Li,Mingjun Zhang,Xiuxiu Liu et al.
Jie Li et al.
The precise ablation of specific cell lineages is crucial for functional studies in vivo. Conventional methods, like the Cre-dependent iDTR system, are constrained by the off-target effects and variable efficiency of single-recombinase appr...
Efficacy of neonatal mouse muscle extracellular vesicles in skeletal muscle repair and regeneration [0.03%]
新生小鼠肌肉细胞外囊泡在骨骼肌修复和再生中的有效性研究
Chengwei Liu,Zhouyan Li,Xinyue Liu et al.
Chengwei Liu et al.
Currently, effective treatments for skeletal muscle injury remain limited. The self-repair of skeletal muscle relies on the activation and differentiation of satellite cells (SCs), which fuse with damaged myofibers to form new fibers and th...
LncRNA nonnmmut065573 promotes post-myocardial infarction cardiac fibrosis and activates the TGF-β1/ZEB1 pathway [0.03%]
非编码RNA nonnmmut065573通过激活TGF-β1/ZEB1通路促进心肌梗死后心室重构中的心脏纤维化的作用及机制研究
Chaowei Hu,Lijie Han,Zhiyong Du et al.
Chaowei Hu et al.
Cardiac fibrosis following myocardial infarction (MI) is a critical determinant of progressive cardiac dysfunction, yet the underlying mechanisms driving this pathological process remain incompletely understood. Elucidating these regulatory...
Transient inhibition of MEK/ERK and WNT pathways enhances direct differentiation of primed hPSCs into functional trophoblast stem cells [0.03%]
瞬时抑制MEK/ERK和WNT通路可增强将预分化的人多能干细胞直接诱导为功能滋养层干细胞的能力
Qifan Jiang,Ping Liu,Chunlin Chen
Qifan Jiang
The placenta plays a pivotal role in human pregnancy, yet research into placental development has been hindered by limited access to early-stage embryos and ethical constraints. Although human trophoblast stem cells (hTSCs) have been establ...
Correction: Endogenous retroviral ERVH48-1 promotes human urine cell reprogramming [0.03%]
correction：内源逆转录病毒ervh48-1促进人尿细胞重编程
Yuling Peng,Jieying Zhu,Qi Zhang et al.
Yuling Peng et al.
Published Erratum
Cell regeneration (London, England). 2026 Jan 19;15(1):3. DOI:10.1186/s13619-026-00281-1 2026
Discovery of a chemical small molecule inducing umbilical cord mesenchymal stem cell differentiation to vascular endothelial cells [0.03%]
脐带间充质干细胞向血管内皮细胞分化诱导小分子的筛选与鉴定
Bangzhao Zhou,Xiaohui Chi,Xinyu Xie et al.
Bangzhao Zhou et al.
Human umbilical cord mesenchymal stem cells (hUC-MSCs) have emerged as promising candidates for clinical applications in vascular disease therapy and in the in vitro modeling of vascular regeneration. However, the translational potential of...
Mammalian mesenchymal stromal cells enhance zebrafish fin regeneration [0.03%]
哺乳动物间充质基质细胞能增强斑马鱼鳍的再生
Dora Sapède,Claudia Terraza-Aguirre,Jholy De La Cruz et al.
Dora Sapède et al.
Mesenchymal stromal cells (MSCs) possess well-described immunoregulatory properties, yet their capacity to drive regeneration in vertebrates is still debated and their mechanisms of action remain to be fully elucidated. In this study, we us...
Alpha-ketoglutarate promotes random-pattern skin flap survival by enhancing angiogenesis via PI3K/Akt/HIF-1α signaling pathway [0.03%]
α-酮戊二酸通过PI3K/Akt/HIF-1α信号通路促进随意皮瓣存活中的作用及机制研究
Jiefeng Huang,Shuangmeng Jia,Yitong Ji et al.
Jiefeng Huang et al.
Random-pattern skin flaps are widely employed in tissue reconstruction, however, their survival is frequently hindered by ischemia, leading to necrosis. Metabolic alterations have been implicated in playing critical roles in angiogenesis du...
When imaging technology meets single-cell omics: new paradigm in developmental biology [0.03%]
当影像技术遇上单细胞组学：发育生物学的新范式
Chunling Wang,Xuejing Zhang,Yifan Zhang et al.
Chunling Wang et al.
Advanced imaging and single-cell omics technologies are fundamentally transforming developmental biology research, shifting it from static observation to dynamic, spatially resolved systems biology. Super-resolution microscopy breaks the di...