Small-molecule cocktail 2SM promotes heart regeneration via inducing embryonic-like cardiomyocyte state [0.03%]
小分子鸡尾酒2SM通过诱导类似胚胎的心肌细胞状态促进心脏再生
Zihao Wang,Lixia Zheng,Xiaokai Ma et al.
Zihao Wang et al.
Adult mammalian cardiomyocytes exhibit limited regenerative capacity, which remains a major challenge for functional recovery after myocardial infarction (MI). Our previous study identified a cocktail of five small molecules (5SM) that prom...
Integrated inference of cellular compositions and gene expression programs by deconvolution [0.03%]
基于去卷积的细胞组成和基因表达程序的综合推理方法
Ze Zhang,Xu Wang,Fan Hong et al.
Ze Zhang et al.
While computational deconvolution is routinely used to estimate cell-type proportions from tissue mixtures, reconstructing cell-type-specific transcriptomes at single-sample resolution remains a fundamentally underdetermined algorithmic cha...
Species-specific functions of CSRP3 in satellite cell-driven muscle regeneration and relevance to porcine stem cell therapy [0.03%]
CSRP3在卫星细胞介导的肌肉再生中的物种特异性功能及其对猪干细胞治疗的意义
Li Zhang,Wenya Li,Mingli Zhu et al.
Li Zhang et al.
Background: Skeletal muscle function deteriorates with injury, disease, or aging. While stem cell therapies offer therapeutic potential, concerns remain regarding the safety and efficacy of transplanted cells. Satellite c...
Jianan Li,Minjie Hu,Lu Ding et al.
Jianan Li et al.
Cardiac regeneration represents a pivotal frontier in addressing cardiovascular diseases, the leading global cause of mortality. This review integrates current advancements in understanding the molecular mechanisms driving cardiomyocyte pro...
Generation of synthetic vascular organoids via orthogonal programming of human pluripotent stem cells [0.03%]
通过正交编程人类多能干细胞生成合成血管器官样组织
Yun Zhao,Mengze Sun,Kun Zhang et al.
Yun Zhao et al.
The development of functional human vasculature is essential for tissue engineering, disease modeling, and regenerative medicine. Conventional differentiation protocols of vascular lineages often exhibit lineage heterogeneity and limited co...
PRMT5 inhibition promotes cross-species spermatogonia expansion and suppresses differentiation [0.03%]
组蛋白甲基化酶PRMT5抑制促进跨物种精原干细胞增殖及分化抑制
Zhaokai Yao,Wen Wang,Kang Tang et al.
Zhaokai Yao et al.
Spermatogonial stem cells (SSCs) hold great promise for treating male infertility, but their clinical translation is impeded by the lack of optimal conditions to maintain their undifferentiated state in vitro. In this study, we focused on e...
Systemic regeneration medicines for muscular dystrophy: progress and challenges in pro-regenerative drug development [0.03%]
肌营养不良的系统性再生药物：促再生型新药研发进展与挑战
So-Ichiro Fukada,Atsushi Kubo,Motoi Kanagawa et al.
So-Ichiro Fukada et al.
Regenerative medicine has the potential to restore lost organ and tissue functions, and research on cell transplantation is steadily advancing toward clinical application. However, significant challenges remain in developing cell therapies ...
Generation of human chemically induced pluripotent stem cells from UC-MSCs [0.03%]
人脐带间充质干细胞化学重编程为化学诱导多能干细胞
Guangqiang Gong,Shanshan Wen,Siyi Huang et al.
Guangqiang Gong et al.
Standard: human breast cancer organoids derived from diverse clinical sample sources [0.03%]
标准：来自不同临床样本来源的类器官模型化人类乳腺癌肿瘤组织球体模型
Zhigang Chen,Ningning Xu,Ming Chen et al.
Zhigang Chen et al.
Breast cancer remains a leading cause of cancer-related morbidity and mortality worldwide, driven by therapeutic resistance, recurrence, and metastasis. Patient-derived organoids (PDOs) have emerged as a robust platform that preserves histo...
Olfactory epithelium regeneration and homeostasis: cellular and molecular mechanisms and novel methodological advances [0.03%]
嗅觉上皮再生和稳态：细胞及分子机制及新的研究方法学进展
Jiaming Qi,Yiqun Yu
Jiaming Qi
The olfactory epithelium (OE) maintains lifelong neurogenesis and shows strong regenerative capacity through the coordinated functions of horizontal basal cells (HBCs) and globose basal cells (GBCs). These progenitors are regulated by key t...