PRMT5 inhibition promotes cross-species spermatogonia expansion and suppresses differentiation [0.03%]
组蛋白甲基化酶PRMT5抑制促进跨物种精原干细胞增殖及分化抑制
Zhaokai Yao,Wen Wang,Kang Tang et al.
Zhaokai Yao et al.
Spermatogonial stem cells (SSCs) hold great promise for treating male infertility, but their clinical translation is impeded by the lack of optimal conditions to maintain their undifferentiated state in vitro. In this study, we focused on e...
Systemic regeneration medicines for muscular dystrophy: progress and challenges in pro-regenerative drug development [0.03%]
肌营养不良的系统性再生药物：促再生型新药研发进展与挑战
So-Ichiro Fukada,Atsushi Kubo,Motoi Kanagawa et al.
So-Ichiro Fukada et al.
Regenerative medicine has the potential to restore lost organ and tissue functions, and research on cell transplantation is steadily advancing toward clinical application. However, significant challenges remain in developing cell therapies ...
Generation of human chemically induced pluripotent stem cells from UC-MSCs [0.03%]
人脐带间充质干细胞化学重编程为化学诱导多能干细胞
Guangqiang Gong,Shanshan Wen,Siyi Huang et al.
Guangqiang Gong et al.
Standard: human breast cancer organoids derived from diverse clinical sample sources [0.03%]
标准：来自不同临床样本来源的类器官模型化人类乳腺癌肿瘤组织球体模型
Zhigang Chen,Ningning Xu,Ming Chen et al.
Zhigang Chen et al.
Breast cancer remains a leading cause of cancer-related morbidity and mortality worldwide, driven by therapeutic resistance, recurrence, and metastasis. Patient-derived organoids (PDOs) have emerged as a robust platform that preserves histo...
Olfactory epithelium regeneration and homeostasis: cellular and molecular mechanisms and novel methodological advances [0.03%]
嗅觉上皮再生和稳态：细胞及分子机制及新的研究方法学进展
Jiaming Qi,Yiqun Yu
Jiaming Qi
The olfactory epithelium (OE) maintains lifelong neurogenesis and shows strong regenerative capacity through the coordinated functions of horizontal basal cells (HBCs) and globose basal cells (GBCs). These progenitors are regulated by key t...
Tollip antagonizes ESCRT-III-mediated plasma membrane repair and cell recovery [0.03%]
Tollip对抗ESCRT-III介导的质膜修复和细胞恢复作用
Julia M Ferrick,Xinan Meng,Emily Morgan et al.
Julia M Ferrick et al.
Cells can recover from sub-lethal necrosis by repairing plasma-membrane (PM) rupture through the ESCRT-III machinery, but how this process is regulated remains unknown. Here, we identify Toll-interacting protein (Tollip) as a conserved nega...
Jiatong Han,Xinyue Yang,Arooj Khabbir et al.
Jiatong Han et al.
Human amniotic membrane (hAM) is a widely used biomaterial with longstanding utility in ophthalmology and emerging therapeutic promise across orthopaedics, obstetrics and gynaecology, and dermatology. Clinically available biological tissue ...
Xingyuan Liu,Huating Wang
Xingyuan Liu
Skeletal muscle possesses a remarkable capacity for regeneration, driven by the activation and proliferation of Pax7-positive muscle stem cells within a dynamic niche that includes immune cells, fibro-adipogenic progenitors, endothelial cel...
MSI1-FTHL17C-iron circuit couples metabolic and epigenetic control of pluripotency in mouse embryonic stem cells [0.03%]
铁死亡途径FTNL17C-MSI1通路结合代谢和表观遗传调控小鼠多能干细胞的多能性
Qianyan Li,Yi Li,Jiazhen Han et al.
Qianyan Li et al.
Maintenance of pluripotency in embryonic stem cells (ESCs) requires coordinated integration of transcriptional, metabolic, and epigenetic programs. Here, we identify a post-transcriptional regulatory axis linking the RNA-binding protein Mus...
Recent advances in TGF-β signaling: insights into regulation, pathophysiological function, and clinical translation [0.03%]
转化生长因子-β信号转导的最新进展：调控、病理生理功能及临床转化研究的新认识
Xiaohua Yan,Junyu Zhang,Carl-Henrik Heldin et al.
Xiaohua Yan et al.
Cytokines from the transforming growth factor-β (TGF-β) superfamily are essential regulators of cell growth, survival, and differentiation, playing a pivotal role in mammalian embryonic development, adult tissue homeostasis, and progressi...