Norbert F Voelkel,Jose Gomez-Arroyo,Shiro Mizuno
Norbert F Voelkel
In this perspective, we review published data which support the concept that many or most chronic and progressive lung diseases also involve the lung vessels and that microvascular abnormalities and endothelial cell death contribute to the ...
Joshua P Fessel,James E Loyd,Eric D Austin
Joshua P Fessel
Pulmonary arterial hypertension (PAH) is a rapidly progressive and fatal disease for which there is an ever-expanding body of genetic and related pathophysiological information on disease pathogenesis. The most common single culprit gene kn...
Jason X-J Yuan,Nicholas W Morrell,S Harikrishnan et al.
Jason X-J Yuan et al.
Ankit Desai,Roberto Machado
Ankit Desai
Activity of Ca -activated Cl channels contributes to regulating receptor- and store-operated Ca entry in human pulmonary artery smooth muscle cells [0.03%]
Ca激活的Cl通道参与人肺动脉平滑肌细胞中受体和内质网介导的Ca流入的调节作用
Aya Yamamura,Hisao Yamamura,Amy Zeifman et al.
Aya Yamamura et al.
Intracellular Ca(2+) plays a fundamental role in regulating cell functions in pulmonary arterial smooth muscle cells (PASMCs). A rise in cytosolic Ca(2+) concentration ([Ca(2+)](cyt)) triggers pulmonary vasoconstriction and stimulates PASMC...
Hypoxic pulmonary hypertension in mice with constitutively active platelet-derived growth factor receptor-β [0.03%]
恒定激活血小板衍生生长因子受体-β小鼠的缺氧性肺动脉高压
Bhola K Dahal,Rainer Heuchel,Soni Savai Pullamsetti et al.
Bhola K Dahal et al.
Platelet-derived growth factor (PDGF) has been implicated in the pathobiology of vascular remodeling. The multikinase inhibitor imatinib that targets PDGF receptor (PDGFR), c-kit and Abl kinases, shows therapeutic efficacy against experimen...
Log-transformation improves the prognostic value of serial NT-proBNP levels in apparently stable pulmonary arterial hypertension [0.03%]
对数转换改善了稳定期内肺动脉高压患者NT-proBNP水平的预后价值
Elaine Soon,Natalie J Doughty,Carmen M Treacy et al.
Elaine Soon et al.
N-terminal pro B-type natriuretic peptide (NT-proBNP) is a product of cleavage of the cardiac prohormone pro B-type natriuretic peptide into its active form. It has proven to be a useful biomarker in left heart failure. However, studies exa...
Air travel can be safe and well tolerated in patients with clinically stable pulmonary hypertension [0.03%]
病情稳定的肺动脉高压患者可以安全坐飞机出行
Melanie Thamm,Robert Voswinckel,Henning Tiede et al.
Melanie Thamm et al.
Our aim was to determine what proportion of patients with pulmonary hypertension (PH) has undertaken air travel contrary to the general medical advice and to characterize these patients according to disease severity and medical treatment. I...
Computational models of the pulmonary circulation: Insights and the move towards clinically directed studies [0.03%]
计算肺循环模型：见解及面向临床研究的发展方向
Merryn H Tawhai,Alys R Clark,Kelly S Burrowes
Merryn H Tawhai
Biophysically-based computational models provide a tool for integrating and explaining experimental data, observations, and hypotheses. Computational models of the pulmonary circulation have evolved from minimal and efficient constructs tha...
Pulmonary vascular wall stiffness: An important contributor to the increased right ventricular afterload with pulmonary hypertension [0.03%]
肺血管壁僵硬度：在肺动脉高压时增加右心室后负荷的重要因素
Zhijie Wang,Naomi C Chesler
Zhijie Wang
Pulmonary hypertension (PH) is associated with structural and mechanical changes in the pulmonary vascular bed that increase right ventricular (RV) afterload. These changes, characterized by narrowing and stiffening, occur in both proximal ...