David P Cork,Amit K Mehrotra,Mardi Gomberg-Maitland
David P Cork
Pulmonary arterial hypertension is a fatal disease. Intravenous prostanoids are often utilized for long-term management of patients. The therapy requires a significant commitment and change in lifestyle for both the patient and family. Tako...
Case Reports
Pulmonary circulation. 2012 Jul;2(3):390-4. DOI:10.4103/2045-8932.101659 2012
Cardiopulmonary exercise testing reveals onset of disease and response to treatment in a case of heritable pulmonary arterial hypertension [0.03%]
cardiopulmonary运动试验揭示了遗传性肺动脉高压的疾病发病和治疗反应
Pia Trip,Anton Vonk-Noordegraaf,Harm Jan Bogaard
Pia Trip
Patients affected by pulmonary arterial hypertension (PAH) show a typical pattern of abnormalities on cardiopulmonary exercise testing (CPET). However, CPET is not routinely used as a screening method. We discuss a patient with hereditary P...
Case Reports
Pulmonary circulation. 2012 Jul;2(3):387-9. DOI:10.4103/2045-8932.101658 2012
The renin-angiotensin system and right ventricular structure and function: The MESA-Right Ventricle Study [0.03%]
肾素血管紧张素系统与右心室结构和功能的关系:MESA右心室研究
Corey E Ventetuolo,Joao A C Lima,R Graham Barr et al.
Corey E Ventetuolo et al.
The pulmonary vasculature is an important site of renin-angiotensin metabolism. While angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers (collectively AIABs) have a role in left ventricular (LV) disease, the impac...
The impact of pulmonary arterial hypertension-targeted therapy on survival in Chinese patients with idiopathic pulmonary arterial hypertension [0.03%]
特发性肺动脉高压靶向治疗对中国患者生存率的影响分析
Wei-Jie Zeng,Yun-Juan Sun,Qing Gu et al.
Wei-Jie Zeng et al.
The survival rates of Chinese patients with idiopathic pulmonary arterial hypertension (IPAH) and familial pulmonary arterial hypertension (PAH) on conventional therapy at 1 and 3 years were 68.0% and 38.9%, respectively. Our aim was to upd...
Comparison of 18F-FDG uptake by right ventricular myocardium in idiopathic pulmonary arterial hypertension and pulmonary arterial hypertension associated with congenital heart disease [0.03%]
特发性肺动脉高压和先天性心脏病相关肺动脉高压右心室心肌摄取18F-FDG的对比研究
Wei Fang,Lan Zhao,Chang-Ming Xiong et al.
Wei Fang et al.
This study measured glucose uptake in the right ventricle (RV) of patients with pulmonary hypertension and investigated the relationship to hemodynamics and survival. Myocardial 18F-fluorodeoxy-glucose (FDG) uptake was measured using single...
An Australian tertiary referral center experience of the management of chronic thromboembolic pulmonary hypertension [0.03%]
澳大利亚三级转诊中心在慢性血栓性肺动脉高压管理方面的经验
Videshinie A Maliyasena,Peter M A Hopkins,Bruce M Thomson et al.
Videshinie A Maliyasena et al.
The objective of this study was to report the outcome of pulmonary endarterectomy (PEA) surgery performed for chronic thromboembolic pulmonary hypertension (CTEPH) at a single tertiary center. The prospective study consisted of 35 patients ...
Testosterone negatively regulates right ventricular load stress responses in mice [0.03%]
睾酮通过下调右心室负荷压力下关键信号分子的表达负向调节小鼠右心室重塑
Anna R Hemnes,Karen B Maynard,Hunter C Champion et al.
Anna R Hemnes et al.
Right ventricular (RV) function is the major determinant of mortality in pulmonary arterial hypertension and male sex is a strong predictor of mortality in this disease. The effects of testosterone on RV structure and function in load stres...
Altered expression of nuclear and cytoplasmic histone H1 in pulmonary artery and pulmonary artery smooth muscle cells in patients with IPAH [0.03%]
特发性肺动脉高压患者肺动脉及平滑肌细胞核型和胞浆型组蛋白H1表达异常
Megha Talati,Erin Seeley,Kaori Ihida-Stansbury et al.
Megha Talati et al.
The pathogenesis of idiopathic pulmonary hypertension is poorly understood. This paper utilized histology-based Matrix-Assisted Laser Desorption Ionization Mass Spectrometry (MALDI MS) to identify as-yet unknown proteins that may be associa...
Pulmonary blood flow and pulmonary hypertension: Is the pulmonary circulation flowophobic or flowophilic? [0.03%]
肺血流量与肺动脉高压:肺循环惧流还是喜流?
Thomas J Kulik
Thomas J Kulik
Increased pulmonary blood flow (PBF) is widely thought to provoke pulmonary vascular obstructive disease (PVO), but the impact of wall shear stress in the lung is actually poorly defined. We examined information from patients having cardiac...
Evan L Brittain,Anna R Hemnes,Mary Keebler et al.
Evan L Brittain et al.
Right ventricular (RV) function is a strong independent predictor of outcome in a number of distinct cardiopulmonary diseases. The RV has a remarkable ability to sustain damage and recover function which may be related to unique anatomic, p...