Fenfluramine-induced gene dysregulation in human pulmonary artery smooth muscle and endothelial cells [0.03%]
芬氟拉明诱导的人肺动脉平滑肌和内皮细胞基因表达异常
Weijuan Yao,Wenbo Mu,Amy Zeifman et al.
Weijuan Yao et al.
Fenfluramine is prescribed either alone or in combination with phentermine as part of Fen-Phen, an anti-obesity medication. Fenfluramine was withdrawn from the US market in 1997 due to reports of heart valvular disease, pulmonary arterial h...
S1P(4) receptor mediates S1P-induced vasoconstriction in normotensive and hypertensive rat lungs [0.03%]
S1P(4)受体介导S1P诱导的正常血压和高血压大鼠肺血管收缩作用
Hiroki Ota,Michelle A Beutz,Masako Ito et al.
Hiroki Ota et al.
This study aimed to identify receptors mediating sphingosine-1-phosphate (S1P)-induced vasoconstriction in the normotensive and chronic hypoxia-induced hypertensive rat pulmonary circulation. In isolated perfused lungs from normoxic rats, i...
Idiopathic and heritable PAH perturb common molecular pathways, correlated with increased MSX1 expression [0.03%]
特发性和遗传性肺动脉高压扰动共同的分子通路，并且与MSX1表达增加相关
Eric D Austin,Swapna Menon,Anna R Hemnes et al.
Eric D Austin et al.
The majority of pulmonary arterial hypertension (PAH) is not associated with BMPR2 mutation, and major risk factors for idiopathic PAH are not known. The objective of this study was to identify a gene expression signature for IPAH. To accom...
Pharmacogenomics in pulmonary arterial hypertension: Toward a mechanistic, target-based approach to therapy [0.03%]
肺动脉高压的药理基因组学：面向机制和靶点的治疗途径
Sami I Said,Sayyed A Hamidi
Sami I Said
Pharmacogenomics is the study of how genetic variations influence the response to drugs, by correlating gene expression with the drug's efficacy and toxicity. This concept has recently been successfully applied in oncology. To test its appl...
Pulmonary hemodynamic responses to inhaled NO in chronic heart failure depend on PDE5 G(-1142)T polymorphism [0.03%]
一氧化氮吸入对慢性心力衰竭患者肺循环血流动力学的影响依赖于PDE5 G(-1142)T多态性
Thibaud Damy,Pierre-François Lesault,Soulef Guendouz et al.
Thibaud Damy et al.
To evaluate the vasoconstrictor component of PH in CHF by investigating the hemodynamic response to inhaled nitric oxide (iNO) and to determine whether this response was influenced by the phosphodiesterase 5 gene (PDE5) G(1142)T polymorphis...
Blood flow redistribution and ventilation-perfusion mismatch during embolic pulmonary arterial occlusion [0.03%]
肺动脉栓塞时的血流重新分布及通气/灌注失匹配
K S Burrowes,A R Clark,M H Tawhai
K S Burrowes
Acute pulmonary embolism causes redistribution of blood in the lung, which impairs ventilation/perfusion matching and gas exchange and can elevate pulmonary arterial pressure (PAP) by increasing pulmonary vascular resistance (PVR). An anato...
MicroRNAs-control of essential genes: Implications for pulmonary vascular disease [0.03%]
微小核糖核酸对肺血管疾病必需基因的调控作用
Sachindra R Joshi,Jared M McLendon,Brian S Comer et al.
Sachindra R Joshi et al.
During normal lung development and in lung diseases structural cells in the lungs adapt to permit changes in lung function. Fibroblasts, myofibroblasts, smooth muscle, epithelial cells, and various progenitor cells can all undergo phenotypi...
Gene H Kim,John J Ryan,Glenn Marsboom et al.
Gene H Kim et al.
Epigenetics refers to changes in phenotype and gene expression that occur without alterations in DNA sequence. Epigenetic modifications of the genome can be acquired de novo and are potentially heritable. This review focuses on the emerging...
Charlotte U Andersen,Ole Hilberg,Søren Mellemkjær et al.
Charlotte U Andersen et al.
Pulmonary arterial hypertension (PAH) is a devastating disease characterized by pulmonary vasoconstriction, pulmonary arterial remodeling, abnormal angiogenesis and impaired right ventricular function. Despite progress in pharmacological th...
Jason Long,Mark J Russo,Charlie Muller et al.
Jason Long et al.
Pulmonary hypertension (PH) is a serious and progressive disorder that results in right ventricular dysfunction that lead to subsequent right heart failure and death. When untreated the median survival for these patients is 2.8 years. Over ...