Depolarization-dependent contraction increase after birth and preservation following long-term hypoxia in sheep pulmonary arteries [0.03%]
羊肺动脉脱极化依赖性收缩出生后的增加和长期缺氧后的保存作用
Demosthenes G Papamatheakis,Jay J Patel,Quintin Blood et al.
Demosthenes G Papamatheakis et al.
Membrane depolarization is critical to pulmonary arterial (PA) contraction. Both L-type Ca(2+) channels (Ca(L)) and Rho-kinase are important signaling components of this process and mitochondrial and non-mitochondrial generated superoxides ...
Three-dimensional analysis of right ventricular shape and function in pulmonary hypertension [0.03%]
肺动脉高压患者右心室形态和功能的三维分析
Peter J Leary,Christopher E Kurtz,Catherine L Hough et al.
Peter J Leary et al.
Right ventricular (RV) failure is a key determinant of morbidity and mortality in pulmonary hypertension (PH). The present study aims to add to existing descriptions of RV structural and functional changes in PH through a comprehensive thre...
Bosentan effects in hypoxic pulmonary vasoconstriction: Preliminary study in subjects with or without high altitude pulmonary edema-history [0.03%]
波生坦对缺氧性肺血管收缩的影响：具有或不具有高海拔肺水肿史的受试者中的初步研究结果
Isabelle Pham,Grégoire Wuerzner,Jean-Paul Richalet et al.
Isabelle Pham et al.
Hypoxia-induced pulmonary vasoconstriction in patients with a medical history of high-altitude pulmonary edema (HAPE) may involve activation of the endothelin-1 (ET-1) pathway. We, therefore, compared the effect of the ETA/ETB receptor anta...
Serum osteoprotegerin is increased and predicts survival in idiopathic pulmonary arterial hypertension [0.03%]
血清骨保护素水平升高可预测特发性肺动脉高压患者的预后
Robin Condliffe,Josephine A Pickworth,Kay Hopkinson et al.
Robin Condliffe et al.
We previously reported that osteoprotegerin (OPG) is regulated by pathways associated with pulmonary arterial hypertension (PAH), and is present at elevated levels within pulmonary vascular lesions and sera from patients with idiopathic PAH...
Cassidy Delaney,David N Cornfield
Cassidy Delaney
In utero, pulmonary blood flow is closely circumscribed and oxygenation and ventilation occur via the placental circulation. Within the first few breaths of air-breathing life, the perinatal pulmonary circulation undergoes a dramatic transi...
Targeting the adventitial microenvironment in pulmonary hypertension: A potential approach to therapy that considers epigenetic change [0.03%]
肺动脉高压靶向外膜微环境的治疗新策略——表观遗传改变的角度
Kurt R Stenmark,Maria G Frid,Michael Yeager et al.
Kurt R Stenmark et al.
Experimental data indicate that the adventitial compartment of blood vessels, in both the pulmonary and systemic circulations, like the connective tissue stroma in tissues throughout the body, is a critical regulator of vessel wall function...
Jason X-J Yuan,Nicholas W Morrell,S Harikrishnan et al.
Jason X-J Yuan et al.
Cardiopulmonary hemodynamic clues for pulmonary vein stenosis diagnosis [0.03%]
心肺循环动力学异常对肺静脉狭窄诊断的提示价值
Mateo Porres-Aguilar,Genaro Fernandez,C Greogery Elliott
Mateo Porres-Aguilar
Pulmonary vein stenosis (PVS) post radiofrequency ablation for chronic atrial fibrillation poses a diagnostic challenge for the clinician. PVS presents with nonspecific symptoms, signs and radiographic features, and may be associated with s...
Hypoxia modulates the expression of leucine zipper-positive MYPT1 and its interaction with protein kinase G and Rho kinases in pulmonary arterial smooth muscle cells [0.03%]
缺氧调节肺动脉平滑肌细胞亮氨酸拉链型阳性MYPT1及其与蛋白激酶G和Rho激酶相互作用表达
Dev K Singh,Joy Sarkar,Aarti Raghavan et al.
Dev K Singh et al.
We have shown previously that acute hypoxia downregulates protein kinase G (PKG) expression and activity in ovine fetal pulmonary vessels and pulmonary arterial smooth muscle cells (SMC). Here, we report that acute hypoxia also reduces the ...
Pulmonary artery endothelium resident endothelial colony-forming cells in pulmonary arterial hypertension [0.03%]
肺动脉内皮驻留内皮集落形成细胞在肺动脉高压中的作用
Heng T Duong,Suzy A Comhair,Micheala A Aldred et al.
Heng T Duong et al.
Proliferative pulmonary vascular remodeling is the pathologic hallmark of pulmonary arterial hypertension (PAH) that ultimately leads to right heart failure and death. Highly proliferative endothelial cells known as endothelial colony-formi...