Expression of mutant BMPR-II in pulmonary endothelial cells promotes apoptosis and a release of factors that stimulate proliferation of pulmonary arterial smooth muscle cells [0.03%]
肺内皮细胞中突变的BMPR-II表达可促进凋亡并释放刺激平滑肌细胞增殖的因素
Xudong Yang,Lu Long,Paul N Reynolds et al.
Xudong Yang et al.
Mutations in the bone morphogenetic protein type II receptor gene (BMPR-II) are the major cause of heritable pulmonary arterial hypertension (PAH). Although both endothelial and smooth muscle cell BMPR-II dysfunction have been seen to contr...
Doppler-defined pulmonary hypertension in medical intensive care unit patients: Retrospective investigation of risk factors and impact on mortality [0.03%]
医学重症监护室患者的多普勒定义的肺动脉高压：风险因素及对死亡率影响的回顾性调查
Jason A Stamm,Bryan J McVerry,Michael A Mathier et al.
Jason A Stamm et al.
Pulmonary hypertension (PH) is poorly characterized in the critically ill. No prior studies describe the burden of or outcomes associated with PH in a general medical intensive care unit population. We hypothesize that PH is an important co...
Protein trafficking dysfunctions: Role in the pathogenesis of pulmonary arterial hypertension [0.03%]
蛋白转运障碍在肺动脉高压发病机制中的作用
Pravin B Sehgal,Jason E Lee
Pravin B Sehgal
Earlier electron microscopic data had shown that a hallmark of the vascular remodeling in pulmonary arterial hypertension (PAH) in man and experimental models includes enlarged vacuolated endothelial and smooth muscle cells with increased e...
Michael E Yeager,Maria G Frid,Kurt R Stenmark
Michael E Yeager
Pulmonary hypertension is characterized by cellular and structural changes in the walls of pulmonary arteries. Intimal thickening and fibrosis, medial hypertrophy and fibroproliferative changes in the adventitia are commonly observed, as is...
Pulmonary Circulation : A new venue for communicating your findings, ideas and perspectives [0.03%]
肺循环：分享您的研究成果、观点和想法的新平台
Jason X-J Yuan,Nicholas W Morrell,S Harikrishnan et al.
Jason X-J Yuan et al.