Blood-CSF barrier clearance of ABC transporter substrates is suppressed by interleukin-6 in lupus choroid plexus spheroids [0.03%]
狼疮脉络丛球体中白细胞介素-6抑制血脑屏障ABC转运底物清除功能
Joshua A Reynolds,Lola Torz,Leslie Cummins et al.
Joshua A Reynolds et al.
Background: The choroid plexus (CP) has been recently implicated in the pathogenesis of the neuropsychiatric manifestations of systemic lupus erythematosus (NPSLE). Lupus patients demonstrate increased serum and cerebrosp...
Choroid plexus organoids reveal mechanisms of Streptococcus suis translocation at the blood-cerebrospinal fluid barrier [0.03%]
脑脊液屏障处链球菌转位的 choroid plexus 组织体研究
Tiantong Zhao,Laura Pellegrini,Bart van der Hee et al.
Tiantong Zhao et al.
Streptococcus suis is a globally emerging zoonotic pathogen that can cause invasive disease commonly associated with meningitis in pigs and humans. To cause meningitis, S. suis must invade the central nervous system (CNS) by crossing the ne...
Age-related cerebral ventriculomegaly occurs in patients with primary ciliary dyskinesia [0.03%]
原发性纤毛运动障碍患者发生年龄相关的脑室扩大现象
Franziska Eisenhuth,Joy E Agbonze,Adam M R Groh et al.
Franziska Eisenhuth et al.
Primary ciliary dyskinesia (PCD) is a genetic disorder causing motile ciliary dysfunction primarily affecting the respiratory and reproductive systems. However, the impact of PCD on the central nervous system remains poorly understood. Rode...
Endothelial and neuronal engagement by AAV-BR1 gene therapy alleviates neurological symptoms and lipid deposition in a mouse model of Niemann-Pick type C2 [0.03%]
由AAV-BR1基因治疗介导的内皮细胞和神经元的相互作用改善Niemann-Pick病C2型小鼠模型的脂质沉积及神经症状
Charlotte Laurfelt Munch Rasmussen,Signe Frost Frederiksen,Christian Würtz Heegaard et al.
Charlotte Laurfelt Munch Rasmussen et al.
Background: Patients with the genetic disorder Niemann-Pick type C2 disease (NP-C2) suffer from lysosomal accumulation of cholesterol causing both systemic and severe neurological symptoms. In a murine NP-C2 model, otherw...
Increasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein [0.03%]
通过额外结合到少突胶质细胞髓鞘寡糖蛋白上延长抗体的脑半衰期，一种特定于中枢神经系统的蛋白质
Marie-Lynn Cuypers,Tom Jaspers,Jarne Clerckx et al.
Marie-Lynn Cuypers et al.
Background: Therapeutic antibodies for the treatment of neurological disease show great potential, but their applications are rather limited due to limited brain exposure. The most well-studied approach to enhance brain i...
A novel method for detecting intracranial pressure changes by monitoring cerebral perfusion via electrical impedance tomography [0.03%]
一种通过监测脑灌注来检测颅内压变化的新型方法：用电阻抗断层扫描法
Ming-Xu Zhu,Jun-Yao Li,Zhan-Xiu Cai et al.
Ming-Xu Zhu et al.
Background: Acute and critical neurological diseases are often accompanied with elevated intracranial pressure (ICP), leading to insufficient cerebral perfusion, which may cause severe secondary lesion. Existing ICP monit...
Exploring the ability of plasma pTau217, pTau181 and beta-amyloid in mirroring cerebrospinal fluid biomarker profile of Mild Cognitive Impairment by the fully automated Lumipulse® platform [0.03%]
探索通过全自动Lumipulse平台检测血浆pTau217、pTau181和β-淀粉样蛋白反映轻度认知障碍脑脊液生物标志物谱型的能力
Marcella Catania,Claudia Battipaglia,Alberto Perego et al.
Marcella Catania et al.
Background: The approval of new disease-modifying therapies by the U.S. Food and Drug Administration and the European Medicine Agency makes it necessary to optimize non-invasive and cost-effective tools for the identifica...
Rh-relaxin-2 attenuates oxidative stress and neuronal apoptosis via ERK-nNOS-NO pathway after germinal matrix hemorrhage in rats [0.03%]
RH- Relaxin-2通过ERK-nNOS-NO信号途径缓解早产儿脑室内出血氧化应激及神经元凋亡
Jun Liu,Yonghua Cai,Khalil Ur Rahman et al.
Jun Liu et al.
Oxidative stress and neuronal apoptosis could be an important factor leading to post-hemorrhagic consequences after germinal matrix hemorrhage (GMH). Previously study have indicated that relaxin 2 receptor activation initiates anti-oxidativ...
In vivo brain delivery of BBB-enabled iduronate 2-sulfatase in rats [0.03%]
利用BBB技术将iduronate 2-硫酸酯酶送到活体大鼠大脑中
Will J Costain,Arsalan S Haqqani,Greg Hussack et al.
Will J Costain et al.
Background: Iduronate-2-sulfatase (IDS) deficiency (MPS II; Hunter syndrome) is a disorder that exhibits peripheral and CNS pathology. The blood brain barrier (BBB) prevents systemic enzyme replacement therapy (ERT) from ...
Cerebrospinal fluid dynamics and subarachnoid space occlusion following traumatic spinal cord injury in the pig: an investigation using magnetic resonance imaging [0.03%]
磁共振成像研究外伤性脊髓损伤后猪的脑脊液动力学和蛛网膜下腔阻塞
Madeleine Amy Bessen,Christine Diana Gayen,Ryan L O&#x;Hare Doig et al.
Madeleine Amy Bessen et al.
Background: Traumatic spinal cord injury (SCI) causes spinal cord swelling and occlusion of the subarachnoid space (SAS). SAS occlusion can change pulsatile cerebrospinal fluid (CSF) dynamics, which could have acute clini...