Distribution of transgene in the rodent choroid plexus after intracerebroventricular injection of adeno-associated virus [0.03%]
经脑室注射腺相关病毒后外源基因在鼠视神经乳头体的分布
John R Pooley,Ali S Bienemann,Alison Young et al.
John R Pooley et al.
Using adeno-associated virus to transfer genetic information to the choroid plexus has emerged as a promising route for long-term gene therapy in the brain for a variety of conditions. Overexpression of proteins has proved effective in smal...
Exploring and translating novel approaches targeting the choroid plexus for the treatment of hydrocephalus: a literature review [0.03%]
探索并翻译针对脉络丛治疗脑积水的新方法：文献回顾
Olivier J J Sluijters,John R Pooley,William G B Singleton
Olivier J J Sluijters
Hydrocephalus is common with a mixed phenotype and aetiology. Its treatment is predominantly surgical, with temporary or permanent cerebrospinal fluid (CSF) diversion, which does not address the underlying disease mechanism. The choroid ple...
Cerebral venous outflow disturbance exacerbates ischemic stroke via an endothelium-initiated inflammatory cascade: an integrated single-cell transcriptomic analysis [0.03%]
脑静脉流出道障碍通过内皮细胞诱发的炎症级联反应加剧缺血性卒中：单细胞转录组整合分析
Shiyan Qian,Ying Zhang,Guoqian Cui et al.
Shiyan Qian et al.
Background: Unfavorable cerebral venous outflow (VO) critically worsens ischemic stroke (IS) prognosis, yet the underlying cellular mechanisms driving this aggravation remain obscure. This study aimed to explore the impac...
Correction: Characterization of blood-brain barrier L-arginine uptake using in situ brain perfusions in a female mouse model [0.03%]
订正：使用体内脑灌流的雌性小鼠模型表征血脑屏障L-精氨酸摄取
Olivia C Milam,Cullen P Wolford,Geoffrey L Pecar et al.
Olivia C Milam et al.
Published Erratum
Fluids and barriers of the CNS. 2026 Jul 19;23(1):88. DOI:10.1186/s12987-026-00839-w 2026
Spatial heterogeneity of the ventricular interface between the median eminence and arcuate nucleus revealed by an unfolded whole-mount view [0.03%]
基于展开的完整组织学视图揭示下丘脑漏斗柄区与弓状核交界处室管膜空间异质性
Yichao Ou,Mengjie Che,Guangsen Wu et al.
Yichao Ou et al.
Background: The median eminence (ME) and adjacent arcuate nucleus (ARC) sit at a unique interface where blood, cerebrospinal fluid (CSF), and hypothalamic circuits meet. However, its continuous organization, postnatal mat...
Hydrocephalus-associated persistent pain: a preclinical investigation correlating brain fluid imbalance and sensory alterations [0.03%]
脑脊液异常与感觉异常相关的先天性脑积水疼痛：临床前研究调查报告
Clara Ciampi,Samuele Trisolini,Lorenzo Di Cesare Mannelli et al.
Clara Ciampi et al.
Background: Hydrocephalus is a neurological disorder characterized by ventricular enlargement, elevated intracranial pressure and long-term complications, including cognitive dysfunction, motor deficits and pain. Despite ...
Ventricular volumetry in relation to clinical response and overdrainage after shunt surgery in idiopathic normal-pressure hydrocephalus: a three-year prospective study [0.03%]
正常压力脑积水分流术后脑室容积变化与临床预后及过度引流的关系：一项为期三年的前瞻性研究
Rafael T Holmgren,Andreas Eleftheriou,Johanna Rydja et al.
Rafael T Holmgren et al.
Background: Idiopathic normal pressure hydrocephalus (iNPH) is treated with shunt surgery, but long-term monitoring of shunt function and complications remains challenging. Traditional radiological measures such as the Ev...
Catheter architecture as a determinant of cerebrospinal fluid flow in pediatric hydrocephalus [0.03%]
导管结构对儿童脑积水脑脊液流动的影响
Christopher W Roberts,Brandon G Rocque,Leopold Arko Iv et al.
Christopher W Roberts et al.
Cerebral ventricular catheters (VCs) remain the critical but failure-prone component of cerebrospinal fluid (CSF) shunt systems for pediatric hydrocephalus, with proximal obstruction accounting for most malfunctions. Several catheter geomet...
Ultrasound-guided versus stereotactically navigated ventriculoperitoneal shunt placement: a randomized clinical trial [0.03%]
超声引导与立体定向导航脑室腹腔分流术置管的比较：一项随机临床试验
Severina Leu,Tim Hallenberger,Jonathan Rychen et al.
Severina Leu et al.
Background: Accurate catheter positioning is essential for optimal outcomes in ventriculoperitoneal shunt (VPS) surgery, while shorter operative times lower infection risk and costs. Navigated VPS placement, using either ...
Randomized Controlled Trial
Fluids and barriers of the CNS. 2026 Jun 26;23(1):85. DOI:10.1186/s12987-026-00833-2 2026
Convergent blood-brain barrier breakdown in schizophrenia and autism spectrum disorders: a systematic review of preclinical animal models [0.03%]
精神分裂症和自闭症谱系障碍的血脑屏障破坏的汇合：系统性回顾动物模型研究
Cristina Morente-Montilla,María Fernández-Guillén,Ana Gómez-Garrido et al.
Cristina Morente-Montilla et al.
Background: Schizophrenia (SCZ) and autism spectrum disorder (ASD) are neurodevelopmental disorders with multifactorial origins involving genetic and environmental risk factors. Both conditions share overlapping pathophys...