CSF Aquaporin-4 levels in controls and in idiopathic normal pressure hydrocephalus before and after shunt surgery [0.03%]
Johan Eriksson De Ryst,Sofia Bergström,Sara Mravinacova et al.
Johan Eriksson De Ryst et al.
Background: Aquaporin-4 (AQP4) is crucial for brain fluid regulation and glymphatic system function. Idiopathic normal pressure hydrocephalus (INPH) is characterized by impaired CSF flow and is treated with shunt surgery....
Mechanistic multiphysics modeling reveals how blood pulsation drives CSF flow, pressure, and brain deformation under physiological and injection conditions [0.03%]
Zhuogen Li,Keyu Feng,Hector Gomez
Zhuogen Li
Intrathecal (IT) injection is an effective way to deliver drugs to the brain bypassing the blood-brain barrier (BBB). To evaluate and optimize IT drug delivery, it is necessary to understand the cerebrospinal fluid (CSF) dynamics in the cen...
Effects of HIV and azidothymidine on Alzheimer's-like pathology and amyloid beta transporters in hu-PBL-NSG mice, brain endothelial amyloid beta uptake and endothelial barrier integrity [0.03%]
Biju Bhargavan,Narendran Annadurai,Georgette D Kanmogne
Biju Bhargavan
Novel paracellular marker based on ᴅ-dipeptide structure for highly sensitive quantification with UPLC-MS/MS for in vitro and in vivo blood-brain barrier permeability analysis [0.03%]
基于ᴅ-二肽结构的新派细胞标志物的定量分析方法用于体外和体内血脑屏障通透性分析
Cindy Bay,Eric Mühlberg,Philipp Uhl et al.
Cindy Bay et al.
Background: The blood-brain barrier (BBB) paracellular permeability must be evaluated in various contexts in vitro and in vivo, including pharmacological evaluation of drug candidates, investigations of pathological chang...
Brain ventricle morphology markers in predicting shunt surgery outcome in idiopathic normal-pressure hydrocephalus [0.03%]
特发性正常压力脑积水脑室形态标志物与脑脊液分流手术预后的关联研究
Andrius Penkauskas,Eemeli Kuukkanen,Anssi Lipponen et al.
Andrius Penkauskas et al.
Background: Idiopathic normal pressure hydrocephalus (iNPH) is characterized by a clinical triad of symptoms: abnormal gait, memory problems, and urinary incontinence. Neuroimaging plays a crucial role in diagnosing iNPH....
Early-onset ventriculomegaly and neuroimmune alterations in Hoatz-deficient mice [0.03%]
霍拉茨缺陷小鼠早期脑室扩张及神经免疫改变
Keishi Narita,Yoshichika Yoshioka,Sayed Sharif Abdali et al.
Keishi Narita et al.
Clinical characteristics and outcomes after shunt surgery in idiopathic normal pressure hydrocephalus with or without prior cerebrospinal fluid tap testing: a single-center follow-up study of 481 patients [0.03%]
腰穿试验阴性的正常压力性脑积水患者脑室-腹腔分流术后临床特征及预后分析：单中心481例患者的随访研究
Kardelen Akar,Lena Kollen,Hanna C Persson et al.
Kardelen Akar et al.
Background: The cerebrospinal fluid tap test (CSF TT) is a commonly used predictive test for selecting patients with idiopathic normal pressure hydrocephalus (iNPH) for shunt surgery, but low sensitivity rate carries the ...
Post-hemorrhagic hydrocephalus of prematurity is associated with disruption of tight junctions and increased macrophage activity in the choroid plexus [0.03%]
早产儿出血后脑积水与脉络丛紧密连接破坏和巨噬细胞活性增加有关
Maria Garcia-Bonilla,Rajiv Swarup,Owen W Limbrick et al.
Maria Garcia-Bonilla et al.
Nanoscopic analysis of tight junction organization in in vitro blood-brain barrier models [0.03%]
基于体外血脑屏障模型的紧密连接纳米尺度分析研究进展
Ayk Waldow,Andreas Brachner,Nicolas Perriere et al.
Ayk Waldow et al.
Choroid plexus modulates subventricular zone adult neurogenesis and olfaction through secretion of small extracellular vesicles [0.03%]
脉络丛通过分泌小型细胞外囊泡调节侧脑室成人神经发生和嗅觉功能
Luke L Liu,Jonathan Shannahan,Wei Zheng
Luke L Liu
The choroid plexus (CP) in the brain ventricles secretes cerebrospinal fluid (CSF) that bathes the adjacent subventricular zone (SVZ). As the largest adult neurogenic region enriched with neural stem/progenitor cells (NSPCs), the SVZ suppli...