A review of cerebrospinal fluid circulation with respect to Chiari-like malformation and syringomyelia in brachycephalic dogs [0.03%]
关于短头狗中的丘脑枕样畸形和脊髓空洞症的脑脊液循环综述
Ryan Jones,Srdjan Cirovic,Clare Rusbridge
Ryan Jones
Cerebrospinal fluid (CSF) plays a crucial role in maintaining brain homeostasis by facilitating the clearance of metabolic waste and regulating intracranial pressure. Dysregulation of CSF flow can lead to conditions like syringomyelia, and ...
Applying machine learning to high-dimensional proteomics datasets for the identification of Alzheimer's disease biomarkers [0.03%]
将机器学习应用于高维蛋白质组学数据集以识别阿尔茨海默病生物标志物
Christoffer Ivarsson Orrelid,Oscar Rosberg,Sophia Weiner et al.
Christoffer Ivarsson Orrelid et al.
Purpose: This study explores the application of machine learning to high-dimensional proteomics datasets for identifying Alzheimer's disease (AD) biomarkers. AD, a neurodegenerative disorder affecting millions worldwide, ...
Research priorities for non-invasive therapies to improve hydrocephalus outcomes [0.03%]
改善脑积水结果的非侵入性疗法的研究重点
Alexandra Hochstetler,Christine Hehnly,William Dawes et al.
Alexandra Hochstetler et al.
The Hydrocephalus Association organized two workshops with the support of the Rudi Schulte Research Institute and Cincinnati Children's Hospital Medical Center entitled "Developing Non-Invasive Hydrocephalus Therapies: Molecular and Cellula...
Ependymal cilia decline and AQP4 upregulation in young adult rats with syringomyelia [0.03%]
年轻成人脊髓空洞症大鼠室管膜纤毛减少和AQP4上调
Longbing Ma,Sumei Liu,Qingyu Yao et al.
Longbing Ma et al.
Background: Syringomyelia was a rare condition characterized by the formation of fluid-filled cysts (syrinx) within the spinal cord, resulting in sensory and motor dysfunction. Currently, there was no satisfactory treatme...
Neurogenesis and glial impairments in congenital hydrocephalus: insights from a BioGlue-induced fetal lamb model [0.03%]
先天性脑积水中的神经发生和胶质细胞损伤：来自BioGlue诱导的羊胎儿模型的启示
Dicle Karakaya,Kristin Lampe,Jose L Encinas et al.
Dicle Karakaya et al.
Background: Congenital hydrocephalus (HCP) is a prevalent condition, that leads to fetal cerebral ventricle dilation and increased intracranial pressure. It is associated with significant neurological impairments, partly ...
Hippocampal vascularization pattern and cerebral blood flow cooperatively modulate hippocampal tolerable amount of Aβ deposition in the occurrence of MCI [0.03%]
海马血管化模式和脑血流共同调节MCI发生时海马可容忍的Aβ沉积量
Yuhao Xu,Hong Wei,Rui Du et al.
Yuhao Xu et al.
Background: Aβ deposition in the brain does not necessarily lead to cognitive impairment, and that blood supply may have other unexplained regulatory effects on Aβ. Therefore, there appears to be a more complex relation...
The glutathione-dependent neuroprotective activity of the blood-CSF barrier is inducible through the Nrf2 signaling pathway during postnatal development [0.03%]
通过Nrf2信号通路在产后发育过程中可诱导依赖谷胱甘肽的脑脊液屏障的神经营养作用
Nathalie Strazielle,Karen Silva,Emmanuel Rault et al.
Nathalie Strazielle et al.
Background: Choroid plexuses regulate the exchanges between the blood and the CSF, and provide trophic factors necessary to brain development. They also express detoxifying enzymes that protect the developing brain from h...
Alanine and glutathione targeting of dopamine- or ibuprofen-coupled polypeptide nanocarriers increases both crossing and protective effects on a blood-brain barrier model [0.03%]
靶向多肽纳米载体的丙氨酸和谷胱甘肽可以增加穿越血脑屏障模型以及保护作用的效果
Mária Mészáros,Thi Ha My Phan,Judit P Vigh et al.
Mária Mészáros et al.
Background: Targeting the blood-brain barrier (BBB) is a key step for effective brain delivery of nanocarriers. We have previously discovered that combinations of BBB nutrient transporter ligands alanine and glutathione (...
Low prevalence of CWH43 variants among Finnish and Norwegian idiopathic normal pressure hydrocephalus patients: a cohort-based observational study [0.03%]
芬兰和挪威特发性正常压力脑积水患者中CWH43变异体的低流行率：基于队列的观察研究
Joel Räsänen,Seppo Helisalmi,Sami Heikkinen et al.
Joel Räsänen et al.
Background: Heterozygous CWH43 loss-of-function (LOF) variants have been identified as iNPH risk factors, with 10-15% of iNPH patients carrying these variants in cohorts from the US. Mouse model harboring CWH43 LOF varian...
Observational Study
Fluids and barriers of the CNS. 2025 Feb 13;22(1):17. DOI:10.1186/s12987-025-00625-0 2025
Kidins220-deficient hydrocephalus mice exhibit altered glial phenotypes and AQP4 differential regulation in the retina and optic nerve, with preserved retinal ganglion cell survival [0.03%]
Kidins220缺陷小鼠的脑积水表现出视网膜和视神经中胶质细胞表型改变以及AQP4的调节差异，而视网膜神经节细胞存活得到保留
Jose A Fernández-Albarral,Ana Simón-García,Elena Salobrar-García et al.
Jose A Fernández-Albarral et al.
Hydrocephalus, characterized by ventriculomegaly due to cerebrospinal fluid accumulation in the cerebral ventricles, is a co-morbidity factor in several neurodevelopmental, psychiatric and neurodegenerative diseases. Aquaporin-4 (AQP4) is c...