Hyphal penetration is the major pathway of translocation of Candida albicans across the blood-cerebrospinal fluid barrier [0.03%]
芽生型穿透是念珠菌病原传播的重要途径
S Schmidt,C Schwerk,H Schroten et al.
S Schmidt et al.
Background: Despite the availability of potent antifungal compounds, invasive fungal disease poses significant morbidity and mortality in immunocompromised patients. Candida albicans is one of the leading pathogens in thi...
CSF outflow from the human spinal canal: preliminary results from an anatomical specimen-based model [0.03%]
基于解剖标本模型的人类脊髓中心室脑脊液流出的初步结果
Radosław Rzepliński,Steven T Proulx,Sylwia Tarka et al.
Radosław Rzepliński et al.
Background: Recent discoveries focused on the role of cerebrospinal fluid (CSF) in metabolite clearance have initiated intense research on CSF circulation and outflow pathways. These studies have focused on the cranial su...
Rutin ameliorates stress-induced blood‒brain barrier dysfunction and cognitive decline via the endothelial HDAC1‒Claudin-5 axis [0.03%]
rutin通过内皮hdac1-claudin-5轴改善应激诱导的血脑屏障功能障碍和认知衰退
Zhao-Wei Sun,Zhao-Xin Sun,Yun Zhao et al.
Zhao-Wei Sun et al.
Background: Emerging evidence suggests that chronic stress compromises blood‒brain barrier (BBB) integrity by disrupting brain microvascular endothelial cells (BMECs), contributing to the development of cognitive impairm...
Enlarged choroid plexus is linked with poorer physical function in rural older adults: a population-based study [0.03%]
扩大脉络丛与农村老年人较差的身体功能有关：一项基于人口的研究所见
Qianqian Xie,Ziwei Chen,Jiafeng Wang et al.
Qianqian Xie et al.
Background: The choroid plexus (ChP) plays an important role in producing cerebrospinal fluid (CSF) and physical dysfunction has been associated with alterations in CSF circulation. However, no population-based studies ha...
Rudy T Chang,Mark J Fisher,Rachita K Sumbria
Rudy T Chang
Brain microvascular endothelial cells (BECs) lining the brain capillaries form the anatomical site of the blood-brain barrier (BBB), providing a highly selective barrier to support brain homeostasis and function. While the BBB acts as a bar...
PepH3-modified nanocarriers for delivery of therapeutics across the blood-brain barrier [0.03%]
PepH3修饰的用于药物跨血脑屏障传输的纳米载体
Anikó Szecskó,Mária Mészáros,Beatriz Simões et al.
Anikó Szecskó et al.
Background: Nanocarriers targeting the blood-brain barrier (BBB) are promising drug delivery systems to enhance the penetration of therapeutic molecules into the brain. Immunotherapy, particularly monoclonal antibodies de...
Is the ischemia found in normal pressure hydrocephalus secondary to venous compression or arterial constriction? A comment on Ohmura et al [0.03%]
正常压力脑积水所发现的缺血是由于静脉受压还是动脉收缩引起？对大村等人的研究进行评价
Grant Alexander Bateman,Alexander Robert Bateman
Grant Alexander Bateman
Background: In a recent study of normal pressure hydrocephalus published by Ohmura et al., there was a progressive reduction in the cerebral blood volume within the cortex, as measured by near-infrared spectroscopy, follo...
VIEshunt: towards a ventricular intelligent and electromechanical shunt for hydrocephalus therapy [0.03%]
VIE分流术：作为脑积水治疗的室 Ventricular Intelligent 电磁分流术的方向
Fabian Flürenbrock,Leonie Korn,Dominik Schulte et al.
Fabian Flürenbrock et al.
Background: Shunt systems for hydrocephalus therapy are commonly based on passive mechanical pressure valves that are driven by the intracranial, intra-abdominal, and hydrostatic pressure. The differential pressure acting...
Hypoxemia exerts detrimental effects on the choroid plexuses and cerebrospinal fluid system in rats [0.03%]
低氧血症对大鼠脉络丛和脑脊液系统产生不利影响
Rawan Barakat,Hameed Al-Sarraf,Zoran Redzic
Rawan Barakat
Background: Hypoxemia can cause secondary acute brain injury, but the mechanisms behind it are not entirely clear and could involve disturbances in the brain extracellular fluids. We aimed to explore the effects of hypoxe...
Ventriculosagittal sinus shunt for treating hydrocephalus with elevated cerebrospinal fluid protein [0.03%]
治疗高蛋白脑脊液的脑积水的室管膜矢状窦分流术
Yikang Wang,Di Wang,Yu Tian et al.
Yikang Wang et al.
This study aimed to investigate the feasibility, acceptability, and preliminary efficacy of a ventriculosagittal sinus (VSS) shunt in the treatment of hydrocephalus with elevated cerebrospinal fluid (CSF) protein content. In this single-cen...