BBB proteomic analysis reveals that complex febrile seizures in infancy enhance susceptibility to epilepsy in adulthood through dysregulation of ECM-receptor interaction signaling pathway [0.03%]
BBB蛋白质组分析揭示复杂性婴儿发热性惊厥通过基底前脑细胞外基质-受体相互作用信号通路的失调增强成年期癫痫的易感性
Qian Wang,Liangyu Pan,Siruan Chen et al.
Qian Wang et al.
Background: Complex febrile seizures (CFS) have been associated with an increased risk of epilepsy in adulthood. However, the specific link between blood-brain barrier (BBB) and the predisposition to epilepsy in adults wh...
Britta Krieger,Barbara Bellenberg,Anna Katharina Roenneke et al.
Britta Krieger et al.
Background: The choroid plexus (ChP) plays a pivotal role in inflammatory processes that occur in multiple sclerosis (MS). The enlargement of the ChP in relapsing-remitting multiple sclerosis (RRMS) is considered to be an...
Multicenter Study
Fluids and barriers of the CNS. 2025 May 8;22(1):47. DOI:10.1186/s12987-025-00656-7 2025
The glycosaminoglycan chains of perlecan regulate the perivascular fluid transport [0.03%]
基底膜蛋白受体多糖链调节周围血管液态运输
Abhishek Singh,Mika Kaakinen,Harri Elamaa et al.
Abhishek Singh et al.
Background: The perivascular conduct pathway that connects the cerebrospinal fluid spaces with the interstitial fluid in the parenchyma are of importance for solute clearance from the brain. In this pathway, the relativel...
Longitudinal changes in ventricular volume after treating aqueduct stenosis through endoscopic third ventriculostomy in adults [0.03%]
内镜下第三脑室造瘘治疗成人导水管狭窄术前后心室容积的纵向变化规律研究
Florian Ebel,Caterina Mariani,Raphael Guzman et al.
Florian Ebel et al.
Background: Assessment of ventricular size following endoscopic third ventriculostomy (ETV) often relies on linear measurements and indexes such as the Evans index (EI) and frontal and occipital horn ratio (FOHR). Long-te...
Glucagon-like peptide-1 receptor modulates cerebrospinal fluid secretion and intracranial pressure in rats [0.03%]
胰高血糖素样肽-1受体调节大鼠脑脊液分泌和颅内压
Mette N Jensen,Ida M E Israelsen,Jonathan H Wardman et al.
Mette N Jensen et al.
Background: Cerebrospinal fluid (CSF) is produced and absorbed at a balanced rate to maintain a constant intracranial pressure (ICP). The CSF dynamics are, however, disturbed in several pathological conditions, leading to...
Correction: The utility of customised tissue probability maps and templates for patients with idiopathic normal pressure hydrocephalus: a computational anatomy toolbox (CAT12) study [0.03%]
对计算解剖学工具箱（CAT12）中特异性脑组织概率图和模板在原发性正常压力脑积水患者中的应用价值的更正通知
Shigenori Kanno,Junyan Liu,Ai Kawamura et al.
Shigenori Kanno et al.
Published Erratum
Fluids and barriers of the CNS. 2025 Apr 22;22(1):40. DOI:10.1186/s12987-025-00655-8 2025
The role of the RING finger protein 213 gene in Moyamoya disease [0.03%]
RING指环蛋白213基因在 moyamoya病中的作用
Xinpeng Deng,Shaosen Zhang,Runsheng Zhao et al.
Xinpeng Deng et al.
Moyamoya Disease (MMD) represents a chronic and progressive cerebrovascular disorder characterized by the gradual occlusion of the terminal portions of the bilateral internal carotid arteries and their major branches, accompanied by the for...
Reactive astrocyte-derived exosomes enhance intracranial lymphatic drainage in mice after intracranial hemorrhage [0.03%]
小鼠颅内出血后反应性星形胶质细胞源外泌体促进颅内淋巴引流
Kexin Li,Yuheng Liu,Junjie Gong et al.
Kexin Li et al.
Background: After intracranial hemorrhage (ICH), the formation of primary hematoma foci leads to the development of secondary brain injury factors such as perihematomal edema (PHE) and accumulation of toxic metabolites, w...
Erythrocyte-derived extracellular vesicles transcytose across the blood-brain barrier to induce Parkinson's disease-like neurodegeneration [0.03%]
红细胞源性胞外囊泡跨转运血脑屏障诱导帕金森病样神经退行性疾病
Hélèna L Denis,Aurélie de Rus Jacquet,Melanie Alpaugh et al.
Hélèna L Denis et al.
Parkinson's disease (PD) is a neurodegenerative illness characterized by motor and non-motor features. Hallmarks of the disease include an extensive loss of dopaminergic neurons in the substantia nigra pars compacta, evidence of neuroinflam...
The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivo [0.03%]
剂量、重数和亲合力对体内TfR介导的大脑递送的影响
Gillian Bonvicini,Sunitha Singh,Lisa Sandersjöö et al.
Gillian Bonvicini et al.
Background: Monovalent binding to the transferrin receptor (TfR) is considered the most efficient mode for high delivery of protein constructs across the blood-brain barrier via TfR-mediated transcytosis at therapeutic do...