Circadian misalignment potentiates blood-brain barrier disruption and mitochondria dysregulation in Zika virus infection [0.03%]
生物钟失调通过血脑屏障损伤和线粒体功能障碍促进寨卡病毒感染
Timea Teglas,Silvia Torices,Anne Caroline Marcos et al.
Timea Teglas et al.
Background: Zika virus (ZIKV) is a mosquito-borne Flavivirus with a strong affinity for the central nervous system (CNS). After infection, ZIKV can cross the blood-brain barrier (BBB) and reach the CNS, causing potential ...
Relationships between measures of neurovascular integrity and fluid transport in aging: a multi-modal neuroimaging study [0.03%]
整合多模态神经影像学技术探讨衰老过程中脑血管单元功能改变及其相关性研究
Ella Rowsthorn,Lachlan Cribb,Benjamin Sinclair et al.
Ella Rowsthorn et al.
Fluid transport in the neurovascular unit is essential for maintaining brain health through nutrient delivery and waste clearance. However, these systems are complex and the inter-dependencies between elements of these systems and how they ...
From inserts to chips: microfluidic culture and 3D astrocyte co-culture drive functional and transcriptomic changes in hiPSC-derived endothelial cells [0.03%]
从插入物到芯片：微流控培养和3D星形胶质细胞共培养驱动hiPSC来源内皮细胞的功能和转录变化
Tuuli-Maria Sonninen,Sanni Peltonen,Sara Kälvälä et al.
Tuuli-Maria Sonninen et al.
Background: The blood-brain barrier (BBB) exhibits a hurdle for drug delivery and development. In addition, the dysfunction of the BBB has been seen in several neurodegenerative diseases, although the mechanisms remain po...
Effects of valproate on the entry of inert hydrophilic markers and expression of tight junction associated genes in the neonatal brain and choroid plexus of a rat model of epilepsy (GAERS) [0.03%]
valsproate对癫痫(GAERS)模型大鼠胎脑和脉络丛通透性的影响及紧密连接相关基因的表达研究
Fiona Qiu,Katarzyna M Dziegielewska,Mark D Habgood et al.
Fiona Qiu et al.
Background: The integrity of blood-brain and blood-cerebrospinal fluid (CSF) barriers is characterised by their ability to restrict transcellular passage of inert, hydrophilic markers of different molecular sizes by tight...
Targeting NLRP3 signaling with a novel sulfonylurea compound for the treatment of vascular cognitive impairment and dementia [0.03%]
靶向NLRP3信号通路的新型磺酰脲类化合物治疗血管性认知障碍和痴呆
Adnan Akif,Thi Thanh My Nguyen,Langni Liu et al.
Adnan Akif et al.
Background: As a key inflammatory factor, the nucleotide-binding oligomerization domain (NOD)-like receptor protein 3 (NLRP3) inflammasome plays a crucial role in neuroinflammation and the progression of neurodegenerative...
Modulation of cerebrospinal fluid secretion facilitated by serotonergic and noradrenergic receptors in the rat choroid plexus [0.03%]
大鼠脑室脉络丛中血清素能和去甲肾上腺素受体促进脑脊液分泌的调节作用
Beatriche L Edelbo,Annette B Steffensen,Eszter O Revesz et al.
Beatriche L Edelbo et al.
Background: The intracranial pressure (ICP) increases at night, partly due to an elevated rate of cerebrospinal fluid (CSF) secretion, which may have therapeutic implications for pressure-related disorders. With similar d...
Proteome profile differences among human, monkey, and mouse brain microvessels and cultured brain microvascular endothelial cells [0.03%]
人、猴和鼠脑微血管及培养的脑微血管内皮细胞蛋白质组谱差异分析
Haruka Kumabe,Takeshi Masuda,Shingo Ito et al.
Haruka Kumabe et al.
Background: The blood-brain barrier (BBB) expresses transporters, receptors, and tight junction proteins that regulate the exchange of substances between the blood and brain. The differences in the expression of these pro...
Choroid plexus enlargement correlates with subcortical tau deposition in progressive supranuclear palsy [0.03%]
脉络丛扩大与进行性核上性麻痹中的皮质下tau沉积相关
Na Wang,JiaYing Lu,XueLing Liu et al.
Na Wang et al.
Objective: The choroid plexus (CP) has gained renewed attention for its role in waste clearance in neurodegenerative disorders. However, its involvement in progressive supranuclear palsy (PSP) remains unclear. This study ...
Idiopathic normal pressure hydrocephalus: associations between CSF biomarkers, clinical symptoms, and outcome after shunt surgery [0.03%]
特发性正常压力脑积水的脑脊液生物标志物、临床症状与分流术后结果之间的关联研究
Majd Saadaldeen,Anna Jeppsson,Per Hellström et al.
Majd Saadaldeen et al.
Background: The neurochemical alterations in cerebrospinal fluid (CSF) associated with the typical symptomatology in idiopathic normal pressure hydrocephalus (iNPH) and their association with outcome after shunt surgery a...
Review of the lumbar infusion test use in pediatric populations: state-of-the-art and future perspectives [0.03%]
儿科人群腰椎输注试验的现状及未来展望：综述
Vojtěch Novák,Adéla Bubeníková,Petr Skalický et al.
Vojtěch Novák et al.
Background: The lumbar infusion test (LIT) is a routine part of the diagnostic process of various CSF dynamics disorders in adults. However, it is rarely used in the paediatric population due to a lack of evidence substan...