Characteristics of patients with idiopathic normal pressure hydrocephalus for whom neurosurgeons hesitate to perform shunt surgery: a nationwide hospital-based survey in Japan [0.03%]
日本全国基于医院的调查：神经外科医师对进行脑室腹腔分流手术犹豫不决的特发性正常压力脑积水患者的特征
Ryo Kawai,Hiroaki Kazui,Tetsuya Ueba et al.
Ryo Kawai et al.
Background: There is no consensus regarding the indications for shunt surgery in patients with idiopathic normal pressure hydrocephalus (iNPH) aged ≥ 85 years or in those with severe physical or mental comorbidities. Thi...
Transcriptomic and histological characteristics of innate immune activation in brain parenchyma in a rat model of neonatal intraventricular hemorrhage [0.03%]
新生脑室内出血大鼠模型脑实质先天性免疫激活的转录组和组织学特征
Miriam Zamorano,Sanjna Udtha,Aidan M Collier et al.
Miriam Zamorano et al.
Background: Intraventricular hemorrhage (IVH) remains a major complication in preterm infants with lifelong sequelae. There is no effective treatment for IVH other than supportive care and surgery for post-hemorrhagic hyd...
Are diurnal variations in glymphatic clearance driven by circadian regulation of Aquaporin-4 expression? [0.03%]
昼夜节律调控的Aquaporin-4表达是否驱动了昼夜差异化的glymphatic清除功能？
Mina Martine Frey,Negar Zohoorian,Nadia Skauli et al.
Mina Martine Frey et al.
Aquaporin-4 (AQP4) is a key astrocytic water channel protein predominantly localized to perivascular endfeet, where it is believed to play a crucial role in brain fluid homeostasis and glymphatic waste clearance. Previous studies have sugge...
F J Parras-Martos,A L Sánchez,C Martínez-Bazán et al.
F J Parras-Martos et al.
The optimization of intrathecal drug delivery procedures requires a deeper understanding of flow and transport in the spinal canal. Numerical modeling of drug dispersion is challenging due to the disparity in time scales: dispersion occurs ...
Per Kristian Eide,Markus Hovd,Are Pripp et al.
Per Kristian Eide et al.
Background: This prospective observational study explored alterations in brain fluid dynamics in patients with spontaneous intracranial hypotension (SIH) and confirmed spinal cerebrospinal fluid (CSF) leakage, specificall...
Observational Study
Fluids and barriers of the CNS. 2025 Jul 1;22(1):65. DOI:10.1186/s12987-025-00679-0 2025
qDESH: a method to quantify disproportionately enlarged subarachnoid space hydrocephalus [0.03%]
量化脑蛛网膜下腔扩张性脑积水的方法
Sofia Behndig,Afroditi Lalou,Jan Axelsson et al.
Sofia Behndig et al.
Background and purpose: Disproportionately enlarged subarachnoid space hydrocephalus (DESH) is a radiological biomarker for idiopathic normal pressure hydrocephalus (iNPH). DESH is a subjective measure, based on visual as...
Perivascular interactions and tissue properties modulate directional glymphatic transport in the brain [0.03%]
血管周围相互作用和组织属性调节脑部胶淋巴运输的方向性
Chenji Li,Sadegh Dabiri,Arezoo M Ardekani
Chenji Li
The glymphatic theory suggests a convective transport mechanism through brain tissue, which has significant implications for both brain waste clearance and drug delivery. However, the existence and driving mechanisms of directional convecti...
Sleep disorders and Alzheimer's disease: relationship and mechanisms involving neuroinflammation, orexin and Aβ [0.03%]
睡眠障碍与阿尔茨海默病：涉及神经炎症、食欲素和Aβ的关系及机制
Wenjing Zhang,Tenghong Lian,Mingyue He et al.
Wenjing Zhang et al.
Aims: Sleep disorders are common in Alzheimer's disease (AD), but the underlying mechanisms are unknown. This study aimed to specifically investigate the relationship between a specific sleep disorder of short sleep durat...
Kirsten G Coupland,Merce Fuentes Amell,Neil J Spratt
Kirsten G Coupland
Background: Cerebrospinal fluid and interstitial fluid dynamics are critical for maintaining homeostasis in the central nervous system. These fluids facilitate waste clearance, micronutrient distribution, and provide a ti...
Deformation of brain in normal pressure hydrocephalus is more readily associated with slow vasomotion rather than heartbeat related pulsations of intracranial pressure [0.03%]
正常压力性脑积水患者大脑变形与缓慢血管运动的关系较心跳相关的颅内压脉动更为密切
Ronald T Murambi,Henora Chour,Magdalena Kasprowicz et al.
Ronald T Murambi et al.
Objective: Enlarged brain ventricles, compressed parasagittal cerebrospinal fluid spaces, steep callosal angle, dilated sylvian fissures and focal cortical sulcal dilatation are typical imaging features of idiopathic norm...