Assessing blood-brain barrier (BBB) integrity in an Alzheimer's disease mouse model: is the BBB globally or locally disrupted? [0.03%]
阿尔茨海默病小鼠模型中血脑屏障（BBB）完整性评估：BBB是广泛受损还是局部受损？
Ehsan Nozohouri,Behnam Noorani,Dhavalkumar Patel et al.
Ehsan Nozohouri et al.
Alzheimer's disease (AD), marked by amyloid-beta (Aβ) plaques and tau tangles, involves cerebral amyloid angiopathy (CAA), which may compromise blood-brain barrier (BBB) integrity. However, the extent and nature of BBB disruption in AD rem...
Neisseria meningitidis regulates P-glycoprotein transporter activity in brain endothelial cells via sphingosine 1-phosphate receptor 1 [0.03%]
脑内皮细胞通过鞘氨醇-1-磷酸受体1调节神经节宁双球菌的P-糖蛋白转运器活性
Fatemeh Nosratabadi,Leo M Endres,Fabian Schumacher et al.
Fatemeh Nosratabadi et al.
Background: The brain endothelial cells (BECs) are essential for protecting the central nervous system (CNS) from xenobiotics and pathogens, including Neisseria meningitidis, while maintaining CNS homeostasis through tigh...
Neuroprotective role of pyrroloquinoline quinone in folate deficiency-induced blood-brain barrier disruption [0.03%]
吡咯喹啉醌在叶酸缺乏引起的血脑屏障损伤中的神经保护作用
Sara Aboulhassane,Vishal Sangha,Md Tozammel Hoque et al.
Sara Aboulhassane et al.
Healthy neurodevelopment requires adequate folates (vitamin B9), which are critical for key biosynthetic and homeostatic processes in the central nervous system (CNS). In the brain, folate transport is mediated by three major pathways: fola...
Imatinib prevents blood-spinal cord barrier disruption by inhibiting PDGFR-mediated JMJD3 expression and activation after spinal cord injury [0.03%]
伊马替尼通过抑制PDGFR介导的JMJD3表达和活化防止脊髓损伤后的血脊髓屏障破坏
Chan Sol Park,Jee Youn Lee,Tae Young Yune
Chan Sol Park
Background: After a spinal cord injury (SCI), disruption of the blood-spinal cord barrier (BSCB) leads to secondary injuries, including inflammatory responses and apoptotic cell death, ultimately causing permanent neurolo...
Ya&#x;el Courtney,Maria K Lehtinen
Ya&#x;el Courtney
The choroid plexus (ChP) epithelium secretes cerebrospinal fluid (CSF) and signaling factors that influence brain development. In addition to classical secretory pathways, the ChP also employs apocrine secretion, in which large cytoplasmic ...
MRI contrast accumulation in features of cerebral small vessel disease: blood-brain barrier dysfunction or elevated vascular density? [0.03%]
小血管病脑部特征的磁共振对比剂积聚：血脑屏障功能障碍或血管密度升高？
Tomas Vikner,Anders Garpebring,Cecilia Björnfot et al.
Tomas Vikner et al.
Background: White matter lesions (WML) and dilated perivascular spaces (PVS) are features of small vessel disease (SVD), commonly observed in aging and dementia, with unknown pathophysiology. Human studies have documented...
Substrate stiffness and shear stress collectively regulate the inflammatory phenotype in cultured human brain microvascular endothelial cells [0.03%]
基质刚度和剪切应力共同调节培养人脑微血管内皮细胞的炎症表型
Alexis K Yates,Heather Murray,Andrew Kjar et al.
Alexis K Yates et al.
Brain endothelial cells experience mechanical forces in the form of blood flow-mediated shear stress and underlying matrix stiffness, but intersectional contributions of these factors towards blood-brain barrier (BBB) impairment and neurova...
Restoring brain barriers: an innovative approach for treating neurological disorders [0.03%]
恢复大脑屏障：治疗神经系统疾病的新方法
Sighild Lemarchant,Britta Engelhardt,Francesca Cicchetti et al.
Sighild Lemarchant et al.
The complex etiology of neurological disorders is a major challenge to the identification of therapeutic candidates. Tackling brain vascular dysfunction is gaining attention from the scientific community, neurologists and pharmaceutical com...
Peripheral inflammatory state in idiopathic normal pressure hydrocephalus patients: a cross-sectional study [0.03%]
特发性正常压力脑积水患者的周围炎症状态：横断面研究
Yang Yang,Dandan Guo,Qingchao Yang et al.
Yang Yang et al.
Background: Neuroinflammation may be involved in the pathogenesis of idiopathic normal pressure hydrocephalus (iNPH). However, the specific changes in the peripheral inflammatory state of patients with iNPH remain unclear...
Uptake of DU145 and LNCaP prostate cancer cell line derived extracellular vesicles is inversely correlated with blood-brain barrier integrity in vitro [0.03%]
人脑微血管内皮细胞体外吸收杜氏前列腺癌细胞系衍生的胞外囊泡与其血脑屏障完整性呈反比关系
Ana Špilak,Adrián Klepe,Sophia Theresa Kriwanek et al.
Ana Špilak et al.
Background: Tumor-derived small extracellular vesicles (sEVs) have been implicated in changes of the blood-brain barrier (BBB) during pre-metastatic niche formation. Although it was postulated that sEVs can traverse the h...