The heart-brain crosstalk in age related cardiovascular and neurodegenerative diseases [0.03%]
心脏神经退行性疾病中的心脑相互作用
Muhammad Ahmad Fahim,Yao Yao,Srinivas M Tipparaju et al.
Muhammad Ahmad Fahim et al.
Aging is a major risk factor for both cardiovascular and neurodegenerative diseases. The bidirectional communication between the heart and brain, commonly referred to as heart-brain crosstalk, is increasingly disrupted with age. In this rev...
Yunwei Shao,Lingling Mai,Ruogu Qiao et al.
Yunwei Shao et al.
The blood-brain barrier (BBB) is a highly selective interface between the peripheral circulation and the central nervous system (CNS), crucial for maintaining brain homeostasis. Disruptions to the BBB, such as increased permeability or stru...
Focused ultrasound-mediated temozolomide delivery into intact blood-brain barrier tissue improves survival in patient-derived xenograft model of glioblastoma [0.03%]
聚焦超声介导的替莫唑胺透过完整血脑屏障组织递送可改善胶质母细胞瘤患者来源异种移植物模型预后
Jaewoo Shin,Jin-Kyoung Shim,Chanho Kong et al.
Jaewoo Shin et al.
High-affinity transferrin receptor binding improves brain delivery of bispecific antibodies at tracer dose [0.03%]
高亲和力转铁蛋白受体结合提高了示踪剂量双特异性抗体的脑传递
Gillian Bonvicini,Sunitha Singh,Lisa Sandersjöö et al.
Gillian Bonvicini et al.
Background: Transferrin receptor (TfR)-mediated transcytosis is a well-established method for delivering biologic therapeutics and diagnostics to the brain. Although moderate affinity towards TfR is beneficial for TfR-med...
Bridging regional neurovascular unit heterogeneity and cognitive function: a review [0.03%]
连接区域神经血管单元异质性和认知功能：综述文章
Amalia Tsintzou,Roseline Poirier,Rania Harati et al.
Amalia Tsintzou et al.
The blood-brain barrier (BBB) is a critical central nervous system interface that tightly regulates the exchange of substances between the blood circulation and the brain parenchyma. The BBB, glia, mural cells and neurons form the neurovasc...
Sleep reduces CSF concentrations of beta-amyloid and tau: a randomized crossover study in healthy adults [0.03%]
睡眠可降低脑脊液中β淀粉样蛋白和tau的浓度：一项健康成年人中的随机交叉试验
Tim Lyckenvik,Martin Olsson,My Forsberg et al.
Tim Lyckenvik et al.
Background: Slow-wave sleep has been proposed to facilitate the removal of proteins, implicated in neurodegeneration, from the brain. While mechanistic evidence from animal models is accumulating, direct human data on how...
Subcortical and white matter alterations in canine ventriculomegaly: an observational volumetric and voxel-based-morphometry study [0.03%]
犬脑室增大的亚皮质及白质变化：一项观察性体积和基于体素形态计量学研究
Tom Cornelius Cyriacks,Martin J Schmidt,Eberhard Ludewig et al.
Tom Cornelius Cyriacks et al.
Objective: Ventriculomegaly and hydrocephalus are frequently found during routine clinical imaging, and hydrocephalus in dogs has been shown to alter brain tissue. Although approaches exist to differentiate canine hydroce...
Halvor Herlyng,Ada J Ellingsrud,Miroslav Kuchta et al.
Halvor Herlyng et al.
Cerebrospinal fluid (CSF) is integral to brain function. CSF provides mechanical support for the brain and helps distribute nutrients, neurotransmitters and metabolites throughout the central nervous system. CSF flow is driven by several pr...
Mixed-dimensional fluid-structure interaction simulations reveal key mechanisms of cerebrospinal fluid dynamics in the spinal canal [0.03%]
混合维度的流固耦合模拟揭示了脊髓管脑脊液动力学的关键机制
Deshik Reddy Putluru,Adrian Buganza Tepole,Hector Gomez
Deshik Reddy Putluru
Cerebrospinal flow dynamics (CSF) plays a critical role in structural disorders of the central nervous system (CNS) and in the design of effective procedures for intrathecal drug delivery. Medical imaging techniques have only partially char...
Identifying a potential role of immune cells in gadolinium deposition within the brain [0.03%]
识别免疫细胞在脑内钆沉积中的潜在作用
Dixy Parakkattel,Nico Ruprecht,Peter Broekmann et al.
Dixy Parakkattel et al.
Background: Gadolinium (Gd) deposition in the brain was observed in patients with history of gadolinium-based contrast agent (GBCA) administration. However, the exact mechanism behind this deposition remains unclear, espe...