Targeting Interleukin-6 as a Novel Strategy to Overcome Eribulin Resistance in Breast Cancer [0.03%]
靶向白细胞介素-6作为克服乳腺癌埃里布林耐药性的新策略
Akira Hattori,Masayuki Nagahashi,Miki Komatsu et al.
Akira Hattori et al.
Background: In breast cancer, elevated serum interleukin-6 (IL-6) level is associated with a poor prognosis during eribulin treatment; however, the mechanisms underlying IL-6-mediated resistance and its potential as a the...
Adjuvant Chemotherapy in Lymph Node-Negative, T1 Triple-Negative Breast Cancer [0.03%]
腋窝淋巴结阴性的T1期三阴性乳腺癌的辅助化疗
Jesus D Anampa,Alvaro Alvarez Soto,Rachel B Jimenez et al.
Jesus D Anampa et al.
Background: The role of adjuvant chemotherapy in small, node-negative triple-negative breast cancer (TNBC) has not been formally assessed in clinical trials. We aimed to evaluate the benefit of adjuvant chemotherapy in th...
Comprehensive Analysis of Genomic Variations in Pancreatic Adenocarcinoma by Race [0.03%]
不同人种胰腺癌的全面基因组变异分析
Mohamad El Moheb,Kaelyn C Cummins,Chengli Shen et al.
Mohamad El Moheb et al.
Purpose: Racial disparities in pancreatic ductal adenocarcinoma (PDAC) incidence and outcomes persist even after adjusting for access to care and treatment received, suggesting a role for tumor-specific molecular factors....
Adequate Catchment Area Representation in Cancer Clinical Trials at NCI Designated Cancer Centers: The University of California Irvine Experience [0.03%]
美国国立癌症研究所指定的癌症机构中癌种临床试验充分涵盖患者地域代表性的UCI经验分析
Frank Lee,Aditya Mahadevan,Armon Azizi et al.
Frank Lee et al.
Background: Ensuring that clinical trial enrollment reflects the demographics and disease burden of a cancer center's catchment area is essential for improving trial accrual and the generalizability of research findings. ...
Plasma Small RNAs as Predictive and Monitoring Biomarkers for Combination Immunotherapy in Advanced Gastric Cancer [0.03%]
用于胃癌免疫联合治疗预测和监测标志物的血浆小RNA研究
Jingshuai Fang,Yan Sun,Yuhui Yu et al.
Jingshuai Fang et al.
Background: Immunotherapy has become a new standard treatment for advanced gastric cancer (aGC). However, current biomarkers are insufficient for accurately identifying true responders, emphasizing the need for novel biom...
Transcriptomic Diversity of Pediatric Acute Myeloid Leukemia Genetic Drivers Correlates With Clinical Outcome and Expression of Stemness-Related Genes [0.03%]
儿童急性髓系白血病的转录组多样性与临床结局和干性相关基因表达有关
Quenton Rashawn Bubb,Elena Sotillo,Rebecca M Richards et al.
Quenton Rashawn Bubb et al.
Background: Pediatric acute myeloid leukemia (pAML) is comprised of a diverse set of oncogenic drivers (ODs) that have been risk-stratified to inform prognosis and therapeutic decision-making. Despite proteomic, transcrip...
Single-Cell Transcriptomic Analysis Identifies a Novel OLR1+ SLC7A7+ Liver-Enriched Metastatic Subset With Immunometabolic Rewiring in Pancreatic Cancer [0.03%]
单细胞转录组分析在胰腺癌中鉴定出一种新的富集于肝脏的免疫代谢重编程亚群OLR1+SCL7A7+
Xuan Yang,Xinyuan Chen,Zixin Wang et al.
Xuan Yang et al.
Background: Pancreatic ductal adenocarcinoma (PDAC) is an exceptionally lethal malignancy, with high percents of patients presenting with liver metastases (LM). However, the mechanisms driving liver metastases remain crit...
Association of Germline Single Nucleotide Polymorphisms in Steroid Hormone Metabolism Pathway With Androgen Deprivation Therapy Prognosis of Prostate Cancer in Chinese Population [0.03%]
中国人群雄激素剥夺治疗预后与类固醇激素代谢途径基因多态性的关联研究
Ruofan Shi,Xiaohao Ruan,Qijun Du et al.
Ruofan Shi et al.
Background: Single nucleotide polymorphisms (SNPs) located in the genes participating in the steroid hormone metabolism pathway may influence the outcomes of androgen deprivation therapy (ADT) in prostate cancer (PCa) pat...
Multicenter Study
Cancer medicine. 2025 Nov;14(21):e71351. DOI:10.1002/cam4.71351 2025
The Impact of Multidisciplinary Team Meetings on the Survival of Stage IV NSCLC Patients [0.03%]
多学科团队会议对IV期非小细胞肺癌患者生存的影响
Zhengyang Lu,Nan Zhang,Qian Gao et al.
Zhengyang Lu et al.
Background: With treatment strategies for cancer constantly evolving, the multidisciplinary team (MDT) plays a key role in optimizing cancer care, but its real-world impact on survival remains unclear. This study aims to ...
Colorectal Cancer Screening Preferences of Recipients and Providers: A Dual-Perspective Discrete Choice Experiment [0.03%]
结直肠癌筛查接受者和提供者的偏好：双重视角离散选择试验结果分析
Weimin Guan,Nan Zhang,Zhengyang Lu et al.
Weimin Guan et al.
Background: The low participation rate in colorectal cancer (CRC) screening may be partly attributed to the lack of consideration for the preferences of both Recipients and Providers. This study aims to explore these pref...