Oral Combined Probiotics Clostridium butyricum and Akkermansia muciniphila Inhibits the Progression of 4T1 Breast Cancer by Activating Bcl-2/Bax Pathway [0.03%]
枯草芽孢杆菌和阿克曼氏菌联合口服益生菌通过激活Bcl-2/Bax信号通路抑制4T1乳腺癌的发展进展
Xiaowei Li,Dengxiong Hua,Daoyan Wu et al.
Xiaowei Li et al.
Background: Breast cancer is the most common malignant tumor among women. Recent studies have found that gut probiotics and their metabolic products play a significant role in activating the immune system, reshaping the t...
Organ-Specific Responses to Nivolumab Plus Ipilimumab in Advanced Hepatocellular Carcinoma: A Multicenter, Retrospective Study [0.03%]
尼伏单抗联合伊匹单抗治疗晚期肝细胞癌的器官特异性反应：一项多中心回顾性研究
Jung Sun Kim,Youngun Kim,Beodeul Kang et al.
Jung Sun Kim et al.
Background: Immune checkpoint inhibitor (ICI) monotherapy elicits limited intrahepatic responses in patients with advanced hepatocellular carcinoma (HCC). Here, we investigate the organ-specific objective response rate (O...
Multicenter Study
Cancer medicine. 2025 Jun;14(11):e70997. DOI:10.1002/cam4.70997 2025
Integrated Analysis of Single-Cell and Bulk RNA-Sequencing Defines N7-Methylguanosine (m7G)-Mediated Modifications' Role in Prognosis and the Tumor Immune Microenvironment in Hepatocellular Carcinoma [0.03%]
单细胞和批量RNA测序的综合分析定义了N7-甲基鸟苷（m7G）介导的修饰在肝细胞癌预后和肿瘤免疫微环境中的作用
Jiahua Liang,Mingjian Ma,Borui Xu et al.
Jiahua Liang et al.
Background: RNA 7-Methylguanosine (m7G) modification is biologically important to tumorigenesis and progression. Knowledge regarding the effect of m7G modification on the clinical features of hepatocellular carcinoma and ...
The Effect of Concomitant Immunotherapy and Stereotactic Radiotherapy, and of Location on Survival in Patients With Brain Metastases From Melanoma [0.03%]
免疫治疗与立体定向放射治疗对转移性黑色素瘤脑转移患者的影响及位置对生存期的影响研究
Chiel B Nijboer,Djura Piersma,Angelique E J Sijben et al.
Chiel B Nijboer et al.
Background: Melanoma is one of the most common causes of brain metastases (BM). Despite recent therapeutic advances, survival in patients with brain metastases from melanoma (MBM) is dismal. In this study, we analyse the ...
Hepatitis B Virus X Protein Upregulates SREBP2 to Modulate Autophagy in Hepatocellular Carcinoma [0.03%]
乙型肝炎病毒X蛋白通过上调SREBP2调节 hepatocellular carcinoma中的自噬现象
Qiuyan Lin,Yongxu Lin,Yongzhu Huang et al.
Qiuyan Lin et al.
Background: The interaction between Hepatitis B virus X protein (HBx) and sterol regulatory element binding protein 2 (SREBP2) in modulating autophagy to influence inflammation and tumorigenesis is not fully understood. T...
High Prevalence of Human Papillomavirus in Vulvar Cancer Among Vietnamese Women: Implications for Vaccination Strategies [0.03%]
越南女性外阴癌人乳头瘤病毒高感染率及其对疫苗策略的启示
D N L Tran,H N Vo,T T A Cung et al.
D N L Tran et al.
Background: Vulvar cancer (VC) is rare; however, its incidence has steadily increased, likely due to increased human papillomavirus (HPV) infections. HPV infection rates vary significantly with age and ethnicity. Data on ...
Estimating Cancer Penetrance in Carriers of BRCA2 Pathogenic Variants Using Cancer-Specific Polygenic Scores [0.03%]
基于癌症特异性多基因评分的BRCA2致病变异携带者癌症外显率估计
Brendan Prassas,Zhuqing Shi,Huy Tran et al.
Brendan Prassas et al.
Introduction: BRCA2 is a causal gene for hereditary breast and ovarian cancer (HBOC) syndrome. However, its association with other cancers and interplay with polygenic scores (PGS) remains unclear. ...
Observational Study
Cancer medicine. 2025 Jun;14(11):e70990. DOI:10.1002/cam4.70990 2025
GABRP Mediates GABA-A Receptor to Shape Tumor Immunosuppressive Microenvironment and Promote Tumor Immune Escape and Corresponding Targeted Therapy [0.03%]
GABRP介导的GABA-A受体调控肿瘤免疫抑制微环境及促进肿瘤免疫逃逸和靶向治疗研究
Wu Cen,Genyuan Fu,Xiaoyu Wang et al.
Wu Cen et al.
Background: Tumor immune evasion mediated by the immunosuppressive tumor microenvironment (TME) remains a major obstacle in cancer therapy. The γ-aminobutyric acid receptor π subunit (GABRP) is aberrantly expressed in c...
Tregs at Diagnosis as a Potential Biomarker for Predicting High-Risk Functionality in Newly Diagnosed Multiple Myeloma [0.03%]
诊断时的Tregs作为潜在生物标志物预测新诊多发性骨髓瘤高危功能性的研究
Qiaolin Zhou,Fang Xu,Jingjing Wen et al.
Qiaolin Zhou et al.
Objective: This study investigated the role of regulatory T cells (Tregs) in newly diagnosed multiple myeloma (NDMM) patients, particularly in relation to early relapse and prognosis. ...
Recent Findings in N6-Methyladenosine Modification and Significance in Pancreatic Cancer [0.03%]
N6-甲基腺苷修饰的最新研究进展及其在胰腺癌中的意义
Tomoaki Hara,Sikun Meng,Yasuko Arao et al.
Tomoaki Hara et al.
Background: RNA modifications are widely detected in cells and are involved in RNA structural stabilization and regulation of gene expression. In cancer cells, RNA modifications are altered, resulting in abnormal expressi...