Baoshen rehabilitation granules ameliorate sepsis-induced acute kidney injury by modulating oxidative stress and mitochondrial damage [0.03%]
宝神康复颗粒通过调节氧化应激和线粒体损伤改善脓毒症诱导的急性肾损伤
Ren Huang,Chunyan Zhang,Yilan Tang et al.
Ren Huang et al.
This study aimed to investigate the therapeutic effects of Baoshen Rehabilitation Granules (BSRG) on sepsis-induced acute kidney injury (AKI) and determine the potential molecular mechanisms involved. A murine model of septic AKI was establ...
Jia Li,Dongquan Zhao,Cheng Li et al.
Jia Li et al.
This study investigates the nephrotoxic effects of varying concentrations of chlorfenapyr on Wistar rat kidneys and human kidney-2 (HK-2) cells. In vivo, chlorfenapyr at concentration of 30 mg/kg led to mild kidney tissue damage, as evidenc...
Combined treatment with mesenchymal stem cells and ROCK inhibitor Y-27632 ameliorates PM2.5-induced lung injury [0.03%]
间充质干细胞联合ROCK抑制剂Y-27632治疗改善PM2.5致肺损伤
He Jiang,Lifang Jin,ShanShan Tan et al.
He Jiang et al.
Particulate matter 2.5 μm (PM2.5) can directly enter the human respiratory tract and cause damage to lungs. Mesenchymal stem cells (MSCs) transplantation has emerged as a promising therapeutic strategy for ameliorating lung injury. Nonethe...
Coexposure to microplastic and arsenic induces prooxidative situation in Laeonereis culveri (Annelida, Polychaeta) [0.03%]
微塑料和砷的联合暴露诱导annelida polychaeta种Laeonereis culveri产生促氧化情况
Larissa Müller,Nágila Villar,Gabriela Côrrea Soares et al.
Larissa Müller et al.
Microplastics (MP) can act as carriers of other contaminants, such as metals, including the metalloid arsenic (As). So, the objective of this study was to evaluate the combined effect of MP and As on the polychaete Laeonereis culveri. The a...
Integrative network toxicology, molecular dynamics and transcriptional analysis elucidate DEHP-induced cardiovascular dysfunction [0.03%]
网络毒理学、分子动力学和转录组分析阐明DEHP所致心血管功能障碍的机制
Yi Guo,Panpan Song,Yanan Liu et al.
Yi Guo et al.
Diethylhexyl phthalate (DEHP), a ubiquitous environmental pollutant, has been linked to cardiovascular diseases (CVDs), though the molecular mechanisms driving this association remain poorly understood. This study employed an integrated app...
TRIM47 promotes trichloroethylene-induced immune kidney injury by degrading SIRT1 through ubiquitination [0.03%]
TRIM47通过泛素化降解SIRT1促进三氯乙烯致免疫性肾损伤
Haibo Xie,Pengcheng Zhou,Chen You et al.
Haibo Xie et al.
Trichloroethylene (TCE) exposure can cause occupational medicamentose-like dermatitis due to trichloroethylene (OMDT) and is often linked to kidney damage. Previous study showed that sirtuin 1 (SIRT1) expression in kidney cells is reduced a...
Alpha-lipoic acid prevents doxorubicin-induced acute hepatorenal toxicity in rats by reducing oxidative and inflammatory stress to suppress autophagy [0.03%]
α-硫辛酸通过减少氧化和炎症压力来抑制自噬以预防阿霉素诱导的大鼠急性肝肾毒性
Yesim Yeni,Betul Cicek,Ahmet Hacimuftuoglu et al.
Yesim Yeni et al.
Doxorubicin (DOX) is a commonly used medicine in cancer therapy. This drug accumulation in healthy tissues causes harmful clinical outcomes. Strategies that reduce oxidative damage, including alpha-lipoic acid (ALA) treatment, have been pro...
Sevoflurane alleviates hypoxia/reoxygenation-induced myocardial cell injury by regulating miR-93-5p [0.03%]
异氟烷通过调节miR-93-5p缓解心肌细胞缺氧/复氧损伤
Qiang Li,Xibao Shi,Jinping Li et al.
Qiang Li et al.
The aim of this study was to investigate the action of miR-93-5p in sevoflurane (Sev) preconditioning to protect against hypoxia/reoxygenation (H/R)-induced myocardial cell injury. H9c2 cells were preconditioned with Sev at concentrations o...
Hsp90 inhibition attenuates the 1, 2-Dichloroethane-induced cognitive impairment by blocking NLRP3 inflammasome activation in mice [0.03%]
HSP90抑制通过阻断NLRP3炎症小体活化缓解二氯乙烷致小鼠认知障碍
Qiangbing Yin,Junling Liu,Wenting Feng
Qiangbing Yin
1,2-Dichloroethane (1,2-DCE) is a widely used industrial solvent known to exert neurotoxic effects upon exposure. Hsp90 inhibition has emerged as a potential therapeutic strategy to mitigate neuroinflammation by targeting the NLRP3 inflamma...
Physico-chemically different carbon nanomaterials may elicit similar inflammatory molecular pathways within the lungs of mice [0.03%]
不同的物理化学性质的碳纳米材料可能会在小鼠肺部引发相似的炎症分子通路
Mariana Seke,Ivan Jovanović,Nataša Mačak et al.
Mariana Seke et al.
Carbon nanomaterials (CNMs) are an integral part of everyday life and their inhalation may cause serious health issues. A transcriptomic lung meta-analysis of five structurally and functionally distinct CNMs was conducted, with the aim of d...