A potential risk of plastic and plasticizer pollution: a molecular toxicological study on DIDP-exacerbated autism-like behaviors in juvenile mice [0.03%]
关于塑化剂污染的潜在风险：DIDP促发小鼠自闭症样行为的分子毒理学研究
Shaohui Chen,Zhuonan Qiu,Qi Peng et al.
Shaohui Chen et al.
Plastic pollution and childhood health are two significant public health issues worldwide. However, there is a lack of corresponding toxicological studies to confirm this association, and the molecular pathological mechanism behind it remai...
Aconitine outperforms mesaconitine and hypaconitine in triggering excessive mitophagy via lysosomal two-pore channels disruption in SH-SY5Y cells and zebrafish [0.03%]
在中国直胆宁和乌头原碱通过破坏溶酶体两孔通道诱发过度线粒体自噬方面的效果优于次乌头原碱方面的作用更为显著（在SH-SY5Y细胞和斑马鱼模型中）
Han Feng,Qiaoxing Mou,Xiaoyu Yan et al.
Han Feng et al.
The genus Aconitum L. is widely used in the treatment of rheumatoid arthritis, tumors, and cardiovascular diseases due to its prominent pharmacological properties. However, increasing scientific attention has been directed toward its neurot...
Tapinanthus globiferus mitigates arsenic-induced oxidative stress and genetic dysregulation In vivo [0.03%]
泰皮南thus属植物通过体内缓解砷引起的氧化应激和基因表达失调作用
Jane-Rose I Oche,Jonathan D Dabak,Titilayo O Johnson
Jane-Rose I Oche
Environmental toxins such as sodium arsenite induce oxidative stress, disrupt redox homeostasis, and trigger oncogenic signaling, providing a model for studying natural redox modulators. This study investigated the protective effects of Tap...
Tirzepatide ameliorates type 2 diabetes-associated male reproductive dysfunction via modulation of the Nrf2/Keap1 pathway [0.03%]
tirzepatide通过调节Nrf2/Keap1通路改善2型糖尿病相关男性生殖功能障碍
Ibrahim Albokhadaim
Ibrahim Albokhadaim
Type 2 diabetes mellitus is closely associated with male reproductive dysfunction driven by oxidative stress, hormonal imbalance, and testicular cell damage. This study evaluated the effects of tirzepatide, a dual agonist of the glucose-dep...
The pivotal role of NF-κB in polymyxin B toxicity: insights from integrated network toxicology and experimental assays [0.03%]
整合网络毒理学和实验分析揭示NF-κB在多粘菌素B毒性中的关键作用
Haoming Yang,Yuan Yin,Pengkai Wang et al.
Haoming Yang et al.
Polymyxin B remains a first-line therapeutic option against Gram-negative bacterial infections; however, its clinical utility is substantially limited by dose-limiting toxicity, the mechanisms of which remain incompletely elucidated. Within...
Integrated bioinformatic analysis identifies ferroptosis-related biomarkers and subtypes in invasive aspergillosis [0.03%]
整合生物信息学分析鉴定侵袭性曲霉病铁死亡相关生物标志物和亚型
Lu Tang,Luying Yang,Weiwei Qian
Lu Tang
Invasive aspergillosis (IA) is a severe fungal infection with complex pathogenesis, and the role of ferroptosis, an iron-dependent regulated cell death, in IA remains largely unexplored. This study investigates the association between ferro...
Mehri Salari,Fatemeh Hojjatipour,Mohammad Jasim Golzarian et al.
Mehri Salari et al.
The use of paraquat as a pesticide exposes users to a high risk of death and morbidity in various organ systems. In Iran, poisoning from this deadly chemical occurs frequently as a result of suicide or accidental use. As such, knowledge abo...
A multi-omics study unravels the mechanism of water pollutants in gastric cancer: integrating network toxicology, machine learning, and tumor microenvironment remodeling [0.03%]
多组学研究揭示了水污染物的胃癌发生机制：整合网络毒理学、机器学习和肿瘤微环境重塑
Wenzhu Lou,Wei Ren,Shuaishuai Huang et al.
Wenzhu Lou et al.
Water pollutants represent a growing environmental concern, yet their specific mechanisms in gastric cancer (GC) remain poorly understood. This study comprehensively investigates the multi-target mechanisms through which water pollutants pr...
Differential genotoxic responses to crystalline and amorphous niobium pentoxide nanoparticles in somatic cells of Drosophila melanogaster [0.03%]
果蝇黑色素细胞中晶型和无定形五氧化二铌纳米颗粒的差异致突变反应
Tatiane Rocha Cardozo,Raíne Fogliati de Carli,Wladimir Hernandez Flores et al.
Tatiane Rocha Cardozo et al.
Niobium pentoxide nanoparticles (NINPs) are increasingly used in technological and biomedical applications due to their chemical stability, biocompatibility, and osteoconductive properties. However, despite their promising use in clinical m...
Investigation of the potential mechanism by which methylparaben induces psoriasis: an integrated study using network toxicology, molecular docking, molecular dynamics simulation, and eight machine learning algorithms [0.03%]
甲基对羟基苯甲酸酯诱导银屑病潜在机制的研究：基于网络毒理学、分子对接、分子动力学模拟及八种机器学习算法的综合研究
Yang Liu,Chenqi Guo,Xinming Chen et al.
Yang Liu et al.
Psoriasis is a chronic inflammatory skin disease with limited safe and effective treatments. Methylparaben, a widely used preservative in cosmetics, pharmaceuticals, and food, is an emerging environmental pollutant linked to immune-related ...