Effects of combined exposure to low levels of aerosolised nickel, copper and arsenic on myocardial injury in rats [0.03%]
低浓度镍、铜和砷气溶胶联合暴露对大鼠心肌损伤的影响
Xinyue Mu,Shuxia Yu,Yiwen Zhang et al.
Xinyue Mu et al.
Chronic low-level exposure to nickel (Ni), copper (Cu), and arsenic (As) may contribute to myocardial injury via oxidative stress. This study investigated the effects of these metals in male Sprague-Dawley rats exposed to aerosols of Ni (0....
Manganese exposure: a study on apoptosis and Ferroptosis in mouse Leydig and Sertoli cells [0.03%]
锰暴露对小鼠Leydig细胞和Sertoli细胞凋亡及铁死亡的影响研究
Jiaqi He,Tongci Li,Yue Su et al.
Jiaqi He et al.
Manganese (Mn), a vital trace element for biological functions, has raised health concerns due to potential toxicity. Excessive Mn impairs male reproduction by reducing testosterone, inducing oxidative stress, and disrupting spermatogenesis...
Ameliorating and therapeutic impact of nano ferrite-chitosan-curcumin nanoparticles against nandrolone decanote induced renal toxicity, inflammation, and oxidative stress in male rats [0.03%]
纳米级壳聚糖-姜黄素铁素体纳米颗粒对雄性大鼠诺龙癸酸酯致肾毒性、炎症和氧化应激的改善和治疗作用
Ehab Tousson,Afaf El Atrash,Somia Zaki et al.
Ehab Tousson et al.
The term ``anabolic-androgenic steroids'' (AASs) refers to a class of artificial substances that resemble the natural testosterone. The most often misused androgen, nandrolone decanoate (ND), is regarded as a public health concern that need...
Modulating intracellular calcium dynamics with alkaloids: A novel strategy against oxidative neurodegeneration [0.03%]
用生物碱调节细胞内钙信号动力学：对抗氧化神经退行性疾病的新型策略
Serap Niğdelioğlu Dolanbay
Serap Niğdelioğlu Dolanbay
Calcium homeostasis plays a pivotal role in neuronal function, and its dysregulation is closely associated with oxidative stress-induced neurotoxicity. This study investigated the protective effects of a methanol alkaloid extract (MAE), ric...
Network toxicology and molecular docking strategy for Analyzing the toxicity and mechanisms of Bisphenol a in hypertension [0.03%]
网络毒理学和分子对接技术在分析双酚A致高血压毒性及机制中的应用分析研究
Wenjie Zhang,Yinming Zhang,Jiawei Tang et al.
Wenjie Zhang et al.
Environmental pollution is an important risk factor for hypertension, and bisphenol A (BPA) is a prevalent environmental contaminant. This study aimed to investigate the potential toxicity of BPA and the underlying molecular mechanisms of B...
Dose-dependent testis infiltration of peritubular macrophages after MEHP exposure of Peri-pubertal rats and their role in the recovery of spermatogenesis [0.03%]
邻苯二甲酸酯代谢物MEHP暴露诱导大鼠睾丸支持细胞巨噬细胞浸润及其参与生精功能恢复的作用及机制研究
Richa Tiwary,Xin Fang,Vivian Nguyen et al.
Richa Tiwary et al.
We have previously reported that acute MEHP exposure resulted in a significant increase in peritubular macrophages along with differentiating spermatogonia. Here, we hypothesize that the recruitment of peritubular macrophages is MEHP dose-d...
Transcriptomics and proteomics reveals the potential mechanisms of hydroquinone-inhibited erythroid differentiation in K562 cells [0.03%]
转录组学和蛋白质组学揭示了对二羟基苯甲醚抑制K562细胞红系分化的作用机制
Chunhong Yu,Jiaxi Chen,Zetao Zhao et al.
Chunhong Yu et al.
Hydroquinone (HQ), a key phenolic metabolite of benzene, plays a crucial role in the mechanisms underlying benzene-induced hematotoxicity and carcinogenicity. The mechanism of benzene-induced hematotoxicity hasn't been fully understood yet....
Doxorubicin chitosan-coated ferrite nanoparticles ameliorate hepatic toxicity in Ehrlich solid tumor bearing mice [0.03%]
壳铁纳米颗粒包被多柔比星及壳聚糖改善Ehrlich实体肿瘤携带小鼠的肝毒性
Maha Elkholy,Osama A Sweef,Ehab Tousson et al.
Maha Elkholy et al.
Malignant tumors, particularly breast malignancies, are leading causes of mortality worldwide due to abnormal cell growth and apoptosis dysregulation, with Ehrlich solid tumors being the most prevalent. This study was designated to study th...
Effects of wasabi (Wasabia japonica) rhizome and its main bioactive compound, allyl isothiocyanate, on the early stages of fibrosis-associated hepatocarcinogenesis [0.03%]
芥末（ Wasabia japonica）根茎及其主要生物活性化合物异硫氰酸烯丙酯对肝癌前期纤维化的影响
Taís Carolina Paes Bronzato,Letícia Cardoso Valente,Agnes Suemy Varicoda et al.
Taís Carolina Paes Bronzato et al.
The poor prognosis of fibrosis-associated hepatocellular carcinoma (HCC) encourages preventive strategies. The wasabi rhizome (Wasabia japonica) - of the Brassicaceae family - is widely used as an ingredient in culinary, and is rich in bioa...
Cytotoxic effects of epsilon toxin from Clostridium perfringens on colon cancer cell lines (HT-29) and (Caco2) in terms of oxidative stress and inflammatory cytokines [0.03%]
产气荚膜杆菌ε毒素对结肠癌细胞系氧化应激和促炎症细胞因子的细胞毒性作用
SeyedAmir Mirabbasi,Masoud Ghane
SeyedAmir Mirabbasi
Bacterial toxins, such as Epsilon toxin (Etx) from Clostridium perfringens, represent a promising, albeit underexplored, avenue for anticancer agent development. This study was therefore designed to systematically investigate the cytotoxic ...