Puerarin alleviates high glucose-induced lens epithelial cell damage by activating the Nrf2 Signaling pathway to inhibit oxidative stress [0.03%]
葛根素通过激活Nrf2信号通路抑制氧化应激缓解高糖诱导的晶状上皮细胞损伤
Juan Xia,Mingli Zhou,Yuandong Ma et al.
Juan Xia et al.
This study investigated Puerarin's protective effects and mechanisms against high glucose (HG)-induced damage in human lens epithelial cells (HLECs), which are relevant to diabetic complications. Using an HG-exposed HLEC model, varying dose...
Albiflorin improves diabetic retinopathy by mitigating oxidative stress and inflammation via the TLR-4/NF-kB signaling pathway [0.03%]
白芍总苷中 albiflorin 通过 toll 样受体 4(NF-κB)信号通路改善糖尿病视网膜病变氧化应激和炎症水平
Liuyi Xie,Yingjun Wang,Yudan Gong
Liuyi Xie
This study was to investigate the effects of Albiflorin (ALB) on oxidative stress and inflammation in diabetic retinopathy (DR) and explore its potential mechanism involving the Toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-κB) si...
Molecular mechanisms of non-pharmaceutical chemicals exposure-induced liver injury: a network toxicology approach [0.03%]
非药物化学物质所致肝损伤的网络毒理学研究进展
Tao Chen,Xing Qian,Zhi Wu
Tao Chen
The exposure to non-pharmaceutical chemicals has been increasingly associated with liver injury, yet the underlying molecular mechanisms remain unclear. This study investigates the impact of three such chemicals-sunset yellow (SUN), tartraz...
Protective effect of L-carnitine on cadmium induced neurotoxicity in rats [0.03%]
左旋肉碱对镉致大鼠神经毒性的保护作用研究
Yan Wang,Yuan Hu,Chunxia Guo et al.
Yan Wang et al.
Cadmium (Cd), a well-known environmental pollutant, widely exists in water, soils, sediments, and air, and produces various system dysfunctions including those affecting the nervous system. L-carnitine (L-CAR) is an antioxidant that plays n...
Accuracy of Pediatric new poisoning mortality score versus poisoning severity score in prediction of in-hospital mortality of acutely poisoned children admitted to Pediatric intensive care unit [0.03%]
儿科新中毒死亡评分与中毒严重度评分预测急性中毒儿童住院死亡率的准确性比较
Meray Medhat Shokry Zaghary,Hend Gamal Aref,Wafaa Abdel-Ghaffar Ali
Meray Medhat Shokry Zaghary
Acute pediatric poisoning is a severe global public health issue that represents a leading cause of morbidity and mortality in pediatrics. The study discussed the accuracy rate of the new PMS to be applied to pediatric acutely poisoned pati...
Nitrate protects against methotrexate-induced liver injury by activating Wnt/β-catenin Signaling in mice [0.03%]
硝酸盐通过激活小鼠Wnt/β-连环蛋白信号通路对抗甲氨蝶呤致肝损伤
Xin Wen,Ying Liu,Chunmei Zhang et al.
Xin Wen et al.
Methotrexate (MTX) is a drug used to treat autoimmune diseases and certain cancers. However, its untreatable hepatotoxic effect severely limits its clinical use. Therefore, further studies are required to combat MTX-induced liver injury. Ni...
Development of an epitope-based vaccine from mycoplasma genitalium adhesion protein: addressing antibiotic resistance through immune-informatics [0.03%]
基于免疫信息学的解脲支原体黏附蛋白表位疫苗设计：应对抗生素耐药性问题
Hafiz Muhammad Rehman,Muhammad Bilal,Muhammad Shoaib et al.
Hafiz Muhammad Rehman et al.
Mycoplasma genitalium is increasingly recognized for its role in severe health conditions, including sexually transmitted infections, ovarian and prostate cancer. The adhesion protein plays a crucial role in the pathogen's ability to attach...
Zebrafish in the spotlight: expanding Frontiers in toxicology and drug discovery [0.03%]
斑马鱼研究备受瞩目：毒理学和药物发现领域的重要进展
Sudharsan Parthasarathy,Shaza H Aly,Siva Vijayakumar Tharumasivam et al.
Sudharsan Parthasarathy et al.
Zebrafish (Danio rerio) has emerged as a valuable model organism in toxicology and drug discovery research. This article provides an overview of the significant contributions of zebrafish to advancing our understanding of toxicology and dru...
Zearalenone induces GnRH neurons activation related to central precocious puberty by triggering MKRN3 auto-ubiquitination and down-regulation [0.03%]
泽拉醇通过诱导MKRN3自泛素化和下调相关中枢性早熟发生及促使GnRH神经元活化的机制研究
Yan Sun
Yan Sun
Central precocious puberty (CPP) refers to gonadotropin-dependent sexual precocity that results from the early activation of the hypothalamic-pituitary-gonadal (HPG) axis. Zearalenone (ZEA), a non-steroidal mycotoxin, is one of the importan...
Hormetic association between sodium nitrate and liver enzymes: a study in female and male rats [0.03%]
硝酸钠与肝脏酶之间的 hormesis 关系——雌雄大鼠研究结果
Ramin Zeinodini,Sajad Jeddi,Khosrow Kashfi et al.
Ramin Zeinodini et al.
This study aims to evaluate the long-term dose-dependent effects of sodium nitrate on serum ALT, AST, and ALP in healthy female and male rats. A total of 120 rats (60 females and 60 males) were divided into 6 subgroups (n = 10). In each sex...