MiR-1291 mediates the protective effect of sevoflurane preconditioning against hypoxia/reoxygenation-induced myocardial cell injury [0.03%]
miR-1291介导异氟醚预处理抗心肌细胞缺氧/复氧损伤的保护效应
Jingyi Shi,Shaoke Hou,Xinyu Yao
Jingyi Shi
The protective effects of sevoflurane (Sev) in cardiovascular disease have been well documented in studies. The investigation aimed to clarify the contribution of miR-1291 to the pathophysiological process of hypoxia-reoxygenation (H/R)-ind...
Examination of the effects of polyunsaturated fatty acids on the alzheimer model caused by amiloid β1-42 toxicity in human SHSY5Y cells by in vitro methods [0.03%]
体外考察多不饱和脂肪酸对人SH-SY5Y细胞Aβ1-42毒性所致阿尔茨海默模型的影响
Mualla Pınar Elci,Sema Ören,Ece Miser-Salihoglu et al.
Mualla Pınar Elci et al.
Alzheimer's disease (AD) is a progressive, chronic disease characterized by impaired cognitive function. Currently, there is no complete cure for ad; current treatments are aimed at reducing symptoms and slowing the progression of the disea...
LPS mediated neuronal c-Fos activation: whole-brain mapping, site and time effect in intoxicated mice [0.03%]
LPS介导的神经元c-Fos活化：染毒小鼠全脑定位及时空效应
Mona N Hussein,Khalid S Alotaibi,Saed A Althobaiti et al.
Mona N Hussein et al.
Lipopolysaccharide (LPS; a bacterial endotoxin) treatment causes acute inflammatory conditions. Acute inflammation causes the brain to activate neurons in some brain nuclei known as circumventricular organs. The c-Fos immunoreaction could b...
Counteracting effects of Ethanolic extract of allium Sativum on Perfluorooctanoic acid-induced cardiotoxicity: insights into Keap1-Nrf2/PPARα pathways [0.03%]
大蒜素乙醇提取物对全氟辛酸诱导的心脏毒性的抑制作用：Keap1-Nrf2/PPARα途径的新见解
Eman El-Sayed Khayal,Hend S Eisa,Marwa Ahmed Abass et al.
Eman El-Sayed Khayal et al.
Perfluorooctanoic acid (PFOA) is a synthetic chemical belonging to per and poly-fluoroalkyl substances. It persists in the environment and accumulates in human bodies, leading to significant health concerns. Allium sativum (garlic) is ackno...
Flumetralin based plant growth regulator used in tobacco cultivation induces immune and cytotoxicity in vitro [0.03%]
基于烟草种植中的氟美替林植物生长调节剂的体外免疫和细胞毒性研究
Aline Mocellin Conte,Fernanda Mocellin Conte,Larissa V Cestonaro et al.
Aline Mocellin Conte et al.
Tobacco production lasts about 10 months and various pesticides are used, including growth inhibitors, which flumetralin is the most used. This is an herbicide that acts as a synthetic and plant growth regulator. Therefore, this work aimed ...
Synthesis, in-vitro, in-silico, and global DNA methylation studies of curcumin-benzoquinone analog in triple-negative breast cancer (TNBC) cells [0.03%]
体外、计算机模拟和全球DNA甲基化研究姜黄素苯醌类衍生物对三阴性乳腺癌细胞的影响
Başak Günçer,Funda Özkök,Ebru Hacıosmanoğlu Aldoğan et al.
Başak Günçer et al.
Curcumin is a well-known anticancer agent used for many malignancies; however, its low bioavailability and solubility limit its use in clinical applications. To enhance its efficacy, we synthesized a novel curcumin-benzoquinone analog, JWB1...
Cigarette smoke impairs the endocytotic process in Saccharomyces cerevisiae [0.03%]
烟草烟雾损害酿酒酵母的内吞作用过程
Aditya Shukla,Srimonti Sarkar,Alok Kumar Sil
Aditya Shukla
The accumulation of misfolded proteins inside the cells has been considered to be an important contributor to the development of cigarette smoke-mediated diseases. Since endocytosis plays a crucial role in protein trafficking and clearance,...
Tanshinone IIA promotes METTL3/METTL14-mediated FDX1 m6A modification to induce cuproptosis in bladder cancer [0.03%]
丹参茋IIA通过促进METTL3/METTL14介导的FDX1m6A修饰诱导膀胱癌铜死亡
Bo Yang,Mengyuan Pan,Tianyi Tao et al.
Bo Yang et al.
Tanshinone IIA (Tan IIA), a pleiotropic bioactive natural compound, has a general anti-tumor effect, as well as in bladder cancer. However, little is known about its mechanism. This work attempts to explore the mechanism of Tan IIA promotin...
Integrated transcriptome analysis of rats exposed to bisphenol mixtures from the fetal to developmental stage [0.03%]
双酚混合物从胎儿期到发育期的大鼠转录组综合分析
Soontag Jung,Yixian Quah,Onju Ham et al.
Soontag Jung et al.
Bisphenol A (BPA), widely used in plastics and resins, has raised health concerns for its endocrine-disrupting effects. BPA analogues such as bisphenol S (BPS) and bisphenol F (BPF) emerged as alternatives but exhibit similar risks. Despite...
The association of organophosphate flame retardants (OPFRs) exposure on omega-3 fatty acids metabolism: evidence derived from the United States general population [0.03%]
有机磷阻燃剂( OPFRs )暴露对ω-3脂肪酸代谢的影响：来自美国普通人群的证据
Ting-Hsuan Hsu,Hsiu-Yung Pan,Kai-Fan Tsai et al.
Ting-Hsuan Hsu et al.
This study investigated the association between exposure to organophosphate flame retardants (OPFRs) and serum omega-3 fatty acid levels in the general U.S. population, using data from 1,350 adults in the 2011-2014 National Health and Nutri...