Integrated bioinformatics and Toxicogenomics reveal bisphenol A-driven molecular networks and prognostic biomarkers in endometrial cancer [0.03%]
集成生物信息学和毒基因组学揭示双酚A驱动的子宫内膜癌分子网络及预后生物标志物
Shuangge Liu,Xiaoxiong Wu,Haojia Li et al.
Shuangge Liu et al.
Bisphenol A (BPA) is a widely used industrial chemical known to exert endocrine-disrupting effects. Recent evidence suggests a potential link between BPA exposure and endometrial cancer. This study aims to investigate the molecular and prog...
Arsenic-induced circFNDC3B regulates apoptosis through dysregulation of NF-κB Signaling [0.03%]
砷通过干扰NF-κB信号通路诱导circFNDC3B调节细胞凋亡
Jinyun Jiang,He Ma,Na Liu et al.
Jinyun Jiang et al.
Arsenic is a widely distributed environmental toxicant that significantly increases the risk of developing multiple tumors. Limited information is available, however, on whether arsenic can regulate circFNDC3B to exert its toxicological res...
A network toxicology approach to elucidate shared oncogenic pathways of Aristolochic acids in prostate, kidney, and bladder cancers [0.03%]
网络毒理学方法阐释 Aristocholic酸 类化合物在前列腺癌、肾癌和膀胱癌中共有的致癌通路
Yuhang Wang,Cong Li
Yuhang Wang
Extensive clinical and epidemiological studies have shown that Aristolochic acids (AA) exhibit significant nephrotoxicity, mutagenicity, and carcinogenicity. This study aimed to systematically explore the potential molecular mechanisms by w...
Propofol triggers mitochondria-mediated apoptosis and c-JUN-mediated epithelial-to-mesenchymal transition in human renal tubular epithelial cells [0.03%]
异丙酚通过线粒体介导的细胞凋亡和c-JUN依赖的上皮间质转化诱导人肾小管上皮细胞损伤
Yanchen Wang,Leguang Yu,Yong Cui et al.
Yanchen Wang et al.
Propofol is a widely used intravenous anesthetic for the induction and maintenance of general anesthesia. Although clinical observations have suggested potential nephrotoxic effects of propofol, experimental evidence remains limited. In thi...
Study the effect of olive extracts on chromium (VI) induced neuro-histo-toxicological defects in adult male albino rats [0.03%]
研究橄榄提取物对六价铬致成年雄性Sprague-Dawley大鼠神经-组织毒性的保护作用
Mohamed M Rezk,Heba A El Masry,Ahmed Aljazzar
Mohamed M Rezk
Many industries are based on chromium, leading to an increase in its environmental residue percentage, especially hexavalent chromium, which increases the risk for several types of cancers and is recognized as a neurotoxicant. Olive oil is ...
Next- Gen Detox: Nanoparticles strategies for liver and kidney toxin removal [0.03%]
下一代解毒技术：用于肝脏和肾脏毒素清除的纳米颗粒策略
Muhammad Irfan,Rimsha Ansar,Sehrish Bint Afzal
Muhammad Irfan
The liver and kidneys are central to maintaining systemic homeostasis by removing endogenous and exogenous toxins. However, toxin accumulation can compromise these organs' detoxification capacity, leading to functional impairment and diseas...
Impact of ViP3Aa 86 expressing transgenic maize on the health of Wistar rats: a toxicological study [0.03%]
ViP3Aa 86转基因玉米对Wistar大鼠健康影响的毒理学研究
Hafiz Muhammad Zeeshan,Ayesha Imran,Saira Azam et al.
Hafiz Muhammad Zeeshan et al.
In the agriculture sector, insects and pests are major constraints to increased global food production. With the advancement in genetic engineering, transgenic crops expressing insecticidal proteins are increasingly prevalent in agriculture...
Acute Petroleum Intoxication in Children: A Prospective Study on Clinical Profile of Toxicity and Therapeutic Efficacy of Combined Inhaled and Parenteral Corticosteroids [0.03%]
儿童急性石油中毒临床特征及吸入与静脉给药糖皮质激素疗效的前瞻性研究
Rania Abdel Maguid Kaka,Safaa Mostafa Elshanawany,Saffa Abdelaziz Mohamed Abdelaziz et al.
Rania Abdel Maguid Kaka et al.
Petroleum ingestion results in one of the most frequent acute unintentional intoxications that affects children in developing nations. Despite being very common, the literature is somewhat poor, with specific studies focused on acute pediat...
Citrinin and cisplatin synergistically induce apoptosis in SKOV3 ovarian cancer cells via redox imbalance and mitochondrial dysfunction [0.03%]
赤霉素和顺铂通过氧化应激失衡和线粒体功能障碍协同诱导SKOV3卵巢癌细胞凋亡
Farzaneh Motafeghi,Ehsan Ghassemi Barghi,Jafar Gholami Gharab et al.
Farzaneh Motafeghi et al.
Cisplatin (Cis), a common drug for ovarian cancer therapy, faces limited effectiveness due to drug resistance. Citrinin (CTN), a mycotoxin known to induce oxidative stress, has been proposed as a potential sensitizing agent to enhance cispl...
Evaluation of the toxicity of essential oil of Senecio brasiliensi s in Drosophila melanogaster [0.03%]
Senecio brasiliensis乙醇提取物对果蝇毒性的评价研究
Roselaine Lima da Vida,Lucas Silva de Baco,Rodrigo Redel Petreceli et al.
Roselaine Lima da Vida et al.
Senecio brasiliensis is a toxic plant from the Asteraceae family, known to contain bioactive compounds with pharmacological and toxicological potential. This study aimed to investigate the toxicity of Senecio brasiliensis essential oil with...