Indoxacarb induces hepatotoxicity in rats via dysregulation of AMPK/SIRT1/NRF-2/ERRα, redox balance and apoptosis [0.03%]
吲哚卡巴诱发大鼠肝毒性的作用机制研究：AMPK/SIRT1/NRF-2/ERRα，氧化还原平衡及凋亡调控失调所致
Hesham M Hassan,Azka Zafar,Muhammad Faisal Hayat et al.
Hesham M Hassan et al.
Indoxacarb (IND) is a toxic pesticide that can cause several organ damages in non-target organisms. However, to date no study has investigated the impacts of IND on hepatic tissues at various concentrations. Therefore, this investigation wa...
Phyllanthin mitigates doxorubicin-induced acute cardiotoxicity: role of Bax/Bcl2 and Caspase-3 regulation [0.03%]
Phyllanthin通过调节Bax / Bcl2和Caspase-3缓解阿霉素引起的心脏急性毒性：作用机制研究
Xumei He,Xiaowei Huo,Jing Zhang et al.
Xumei He et al.
Doxorubicin (DOX)-induced toxicity impairs cardiovascular functions. Phyllanthus amarus exhibits anti-inflammatory, antiviral, anticancer, antioxidant, nephroprotective, and hepatoprotective effects. However, its potential against DOX-induc...
Silencing SOX2-OT alleviates A β-induced damage to neurons and microglial cells by targeting miR-143-3p in Alzheimer's disease [0.03%]
SOX2-OT沉默通过靶向miR-143-3p缓解阿尔茨海默病中Aβ诱导的神经元和小胶质细胞损伤
Ting Huang,Xichun Wang,Yumei Liu
Ting Huang
This research focuses on examining the function of the long non-coding RNA SOX2-OT in Alzheimer's disease (AD) and its interaction with the microRNA miR-143-3p, revealing their functions in neurons and microglial cells and their effects on ...
Assessment of the serum glucose/potassium ratio and leucocyte glucose index as predictors of poor outcomes in acute clozapine poisoning: a risk score model construction [0.03%]
血清葡萄糖/钾比值和白细胞葡萄糖指数作为急性氯氮平中毒不良预后的预测因子的评估：风险评分模型构建
Rasha Elhussieny Elsharkawy,Heba Ibrahim Lashin,Howaida Saeed Mohammed
Rasha Elhussieny Elsharkawy
Clozapine is a highly effective atypical antipsychotic in treatment of patients with schizophrenia. Acute clozapine poisoning is commonly reported worldwide. This cohort study aimed to assess the serum glucose/potassium ratio and leucocyte ...
Seed extract of Annona muricata reverses the reproductive toxicity and oxidative stress induced by cyclophosphamide in drosophila melanogaster [0.03%]
Annona muricata种子提取物逆转环磷酰胺诱导的果蝇生殖毒性和氧化应激作用
Luther Luka Makwin,Walter Mdekera Iorjiim,Kennedy Amagon et al.
Luther Luka Makwin et al.
Cyclophosphamide, a widely used chemotherapeutic agent and immunosuppressant, is linked to significant oxidative stress and reproductive toxicities. While various strategies aim to mitigate these effects, the protective potential of Annona ...
Phlda1 stabilized by Mettl14-mediated m6A modification promotes lipopolysaccharide-induced acute lung injury [0.03%]
METTL14介导的PHDLA1m6A修饰促进脂多糖诱导的急性肺损伤
Jie Pan,Yuanyuan Chen
Jie Pan
Pleckstrin homology-like domain family A member 1 (Phlda1) has been reported to be involved in regulating cell proliferation, death, immune responses, and oxidative stress. Here, this study investigated the functions and mechanisms of Phlda...
Role of aspartate aminotransferase in predicting Pediatric carbon monoxide poisoning outcomes: a Multicenter retrospective cohort study [0.03%]
天冬氨酸氨基转移酶在预测儿童一氧化碳中毒预后中的作用：一项多中心回顾性队列研究
Xin-Hong Lin,Hsiu-Yung Pan,Wei-Ting Wu et al.
Xin-Hong Lin et al.
This multicenter retrospective cohort study investigated prognostic markers for clinical outcomes and delayed neurological sequelae (DNS) in pediatric patients with carbon monoxide poisoning (COP). We analyzed data from patients under 17 yr...
Effects of Low-Dose Silver Nanoparticles on Odontoblastic Mineralization and Inflammatory Responses under an Inflammatory Microenvironment Subtitle: Involvement of the PI3K/Akt-NF-κB Signaling Pathway in MDPC-23 Cells [0.03%]
低剂量银纳米颗粒对炎性微环境下牙本质细胞矿化及炎症反应的影响及在MDPC-23细胞中PI3K/AKT-NF-κB信号通路的介导作用
Xiaotong Wang,Changchang Lu,Jianshan Chen et al.
Xiaotong Wang et al.
Silver nanoparticles (AgNPs) are extensively applied in biomedical fields due to their antimicrobial properties, but their regulatory effects on odontogenic cells under inflammatory conditions remain unclear. This work sought to analyze low...
Monoterpene-rich essential oil from Artemisia santonicum L. exerts neuroprotective effects in Aβ-induced SH-SY5Y cells: Modulation of tau pathology, neuroinflammation, oxidative stress, and synaptic-metabolic pathways [0.03%]
艾纳菊精油通过调节tau蛋白病理、神经炎症、氧化应激及突触-代谢通路对Aβ诱导的SH-SY5Y细胞具有神经营养保护作用
Serap Nigdelioglu Dolanbay
Serap Nigdelioglu Dolanbay
Understanding the complex biological mechanisms of ad requires innovative treatment approaches for this disease. In this context, natural compounds, especially monoterpenes, attract attention with their potential for biological activity. In...
Deciphering the role of air pollution in hepatocellular carcinogenesis: insights from network toxicology and machine learning approaches [0.03%]
基于网络毒理学和机器学习方法探讨空气污染在肝细胞癌发生发展中的作用机制
Senlin Xiao,Ankang Wang,Zhihui Chen et al.
Senlin Xiao et al.
Air pollution has emerged as a major public health concern, being implicated in the pathogenesis of diverse diseases. This study investigates the underlying associations between air pollutants and hepatocellular carcinoma (HCC). Target gene...