Genotoxic, histologic, immunohistochemical, morphometric and hormonal effects of di-(2-ethylhexyl)-phthalate (DEHP) on reproductive systems in pre-pubertal male rats [0.03%]
邻苯二甲酸二(2-乙基己基)酯(DEHP)对青春期前雄性大鼠生殖系统染色体毒性和组织学、免疫组化、形态计量及激素的影响
Gözde Karabulut,Nurhayat Barlas
Gözde Karabulut
Di-(2-ethylhexyl) phthalate (DEHP) is widely used as a plasticizer and people are exposed to various amounts on a daily basis. This study was designed to evaluate the genotoxic, histologic, immunohistochemical, morphometric and hormonal eff...
Oxidative stress and mitochondrial impairment mediated apoptotic cell death induced by terpinolene in Schizosaccharomyces pombe [0.03%]
香荆芥酚诱导的模式真核单细胞模式生物氧化损伤及线粒体介导的凋亡机制研究
Hizlan H Agus,Cemaynur Sarp,Meryem Cemiloglu
Hizlan H Agus
Terpinolene is one of the most abundant monoterpenes used as a food supplement or odorant in cosmetics and the pharmaceutical industry. In this study, we aimed to assess apoptotic, oxidative and cytotoxic effects of terpinolene. We used the...
Wei Hong,Yan Liu,Ming-Hui Li et al.
Wei Hong et al.
Owing to the promising applications of C-dots in biomedical engineering, concerns about their safety have drawn increasing attention recently. In this study, mice were intraperitoneally injected at different C-dot concentrations (0, 6.0, 12...
NF-κB-vimentin is involved in steroidogenesis stimulated by di- n-butyl phthalate in prepubertal female rats [0.03%]
邻苯二甲酸丁酯诱导的大鼠皮质卵泡颗粒细胞类固醇生成的NF-κB-波形蛋白信号途径参与机制研究
Chang Zhang,Pan Gong,Yan Ye et al.
Chang Zhang et al.
This study was aimed at assessing steroidogenesis stimulated by low-dose exposure to DBP in prepubertal female rats. Animals were gavaged with DBP from postnatal day 21 to 33 at 0, 1, 10 and 500 mg kg-1 day-1. 500 mg kg-1 day-1 was selected...
Sinem Ilgin,Volkan Kilic,Merve Baysal et al.
Sinem Ilgin et al.
Sertraline is an antidepressant that is frequently prescribed to treat depression, obsessive-compulsive disorder, panic disorder, and anxiety. This drug had a safe cardiotoxicity profile, until the reporting of cases of sertraline-associate...
Effects of exposure of adult mice to multi-walled carbon nanotubes on the liver lipid metabolism of their offspring [0.03%]
暴露于多壁碳纳米管的成年小鼠对其后代肝脂代谢的影响
Hong-Yu Zhang,Ru-Long Chen,Yang Shao et al.
Hong-Yu Zhang et al.
Objective: To explore the toxicity of multi-walled carbon nanotubes (MWCNTs) on the liver lipid metabolism of offspring mice and the possible mechanisms involved. Method: Virgin female (16-18 g) and male (18-20 g) C57BL/6 mice were randomly...
The mitochondrial pathway is involved in sodium fluoride (NaF)-induced renal apoptosis in mice [0.03%]
mitochondrial途径参与了氟化钠诱导的小鼠肾脏细胞凋亡
Qin Wei,Qin Luo,Huan Liu et al.
Qin Wei et al.
The objective of the present study was to explore the molecular mechanism of apoptosis induced by sodium fluoride (NaF) in the mouse kidney by using the methods of flow cytometry, quantitative real-time polymerase chain reaction (qRT-PCR), ...
Effect of the calcination process on CdO-ZnO nanocomposites by a honey-assisted combustion method for antimicrobial performance [0.03%]
热处理过程对蜂蜜辅助燃烧法制备的CdO-ZnO纳米复合材料抗菌性能的影响
Gopi Somasundaram,Jayaprakash Rajan,Justin Paul
Gopi Somasundaram
This work reports on honey as a combustion agent of CdO : ZnO nanocomposites and the effects of further annealing (100 °C, 200 °C, 300 °C and 400 °C) on their structural, optical, morphological, elemental, electrical and antimicrobial p...
Hemolytic and cellular toxicology of a sulfanilamide-based nonionic surfactant: a niosomal carrier for hydrophobic drugs [0.03%]
一种基于磺胺类的非离子型表面活性剂的溶血及细胞毒理学：疏水性药物的尼奥斯omes载体
Imdad Ali,Muhammad Raza Shah,Sammer Yousuf et al.
Imdad Ali et al.
Biocompatible surfactants are of diverse pharmaceutical interest due to their ability to self-assemble into nano-particulate systems which can be used for single-step drug loading, based upon the hydrophobic-hydrophobic interaction between ...
Perturbation of microRNA signalling by doxorubicin in spermatogonial, Leydig and Sertoli cell lines in vitro [0.03%]
多柔比星对体外小鼠支持细胞、类固醇生成细胞和干细胞系中微核糖核酸信号的干扰作用研究
Oluwajoba O Akinjo,Timothy W Gant,Emma L Marczylo
Oluwajoba O Akinjo
We have previously shown that in addition to its widely recognised cardiotoxicity, the chemotherapeutic doxorubicin (DOX) is able to induce transcriptional, microRNA (miRNA) and DNA methylation changes in the mouse testis. These changes per...