Pathology of experimental arsenic toxicity in rats and investigation of protective effect of simultaneously administered Cistus laurifolius L. (Cistaceae) [0.03%]
受体实验性砷毒理病理变化及同时服用牻牛儿苗对病情保护作用的研究
Hasan Huseyin Demirel,Erkan Karadas,Esra Kupeli-Akkol
Hasan Huseyin Demirel
Sodium arsenite is abundantly available in the environment, and arsenic toxicity is a public health problem that raises concerns worldwide. In this study, the protective effect of Cistus laurifolius L. (Cistaceae) against sodium arsenite-in...
A comparison of different scores for mortality prediction of acutely poisoned patients: a systematic review and meta-analysis [0.03%]
急性中毒患者死亡预测的评分系统比较：系统评价和meta分析
Meng Wei,Xiaopeng Tu,Huan Li et al.
Meng Wei et al.
Acute poisoning typically accounts for 1%-3% of all emergency department (ED) visits, and comprise 4%-40% of admissions to intensive care units (ICU), with a mortality rate of 3%-6%. Accurate assessment of patient prognosis enables the earl...
Network toxicology and immune-metabolic dysregulation: linking per- and polyfluoroalkyl substances exposure to osteoarthritis pathogenesis [0.03%]
网络毒理学和免疫代谢失调：将含氟化合物暴露与骨关节炎发病机制联系起来
Qian Zhang,Wenqi Zhang,Zhuchen Liu et al.
Qian Zhang et al.
Per- and polyfluoroalkyl substances (PFAS) are emerging environmental contaminants linked to various health conditions. However, the molecular mechanisms by which PFAS contribute to OA remain unclear. This study integrates network toxicolog...
Exploring the role of key gene PTTG1 in clear cell renal carcinoma based on bioinformatics analysis and In-vitro cell experiments [0.03%]
基于生物信息学分析及体外细胞实验探究关键基因PTTG1在透明细胞肾癌中的作用
Li-Hui Guan,Yu-Dong Wu
Li-Hui Guan
This study aimed at exploring the expression characteristics and functional roles of PTTG1 in ccRCC by bioinformatics analysis and in-vitro experiments. Differentially expressed genes were screened based on TCGA-KIRC and GSE168845 and the p...
The ameliorative effects of metformin and taurine against thioacetamide hepatotoxicity in rats [0.03%]
替考拉宁和牛磺酸对硫代乙酰胺致大鼠肝毒性的改善作用
Sherouk S Badawy,Mohammad M Mashaly,A F Abdel-Aziz et al.
Sherouk S Badawy et al.
The main objective of this research was to investigate the therapeutic, anti-inflammatory, and histological effects of metformin and taurine, both alone and in combination, against thioacetamide (TAA)-induced hepatotoxicity in rats. The stu...
Hepatoprotective mechanisms of ginkgo-Biloba and dandelion extracts: antioxidant activity and modulation of TNF-α and P53 pathways in Thioacetamide-induced liver injury [0.03%]
银杏和蒲公英提取物的保肝机制：抗氧化活性及调节硫代乙酰胺致肝损伤中TNF-α和P53通路的作用
Heba M Shaaban,El-Sayed E Mehana,Samah S Oda et al.
Heba M Shaaban et al.
Liver injuries, especially those induced by chemical toxins and pharmaceuticals, are increasingly prevalent. This study evaluated the hepatoprotective effects of Ginkgo biloba and dandelion extracts in a rat model of thioacetamide (TAA)-ind...
Use of new approach methodology for hepatic safety assessment of covalent inhibitor drug candidates [0.03%]
共价抑制剂药物候选物的肝安全性评估的新方法学应用
Sara Amberntsson,Alison J Foster,Bhavik Chouhan et al.
Sara Amberntsson et al.
Interest in inhibiting target proteins through covalent binding mechanisms has increased in the last decade due to the potential for beneficial pharmacological properties. However, the inherent targeted covalent inhibitor (TCI) adverse off-...
Protective effects of apricot kernel oil and metformin against BPA-induced ovarian toxicity in rat models of polycystic ovary syndrome: insights into PI3K/AKT and mitochondrial apoptosis pathways [0.03%]
杏仁油和二甲双胍对BPA诱导的多囊卵巢综合征大鼠模型卵巢毒性防护作用：PI3K/AKT和线粒体凋亡途径的新见解
Xuejuan Jiao,Qianqian Zhang,Guoliu Ye et al.
Xuejuan Jiao et al.
In this study, the therapeutic synergistic effects of metformin (MET) and Apricot Kernel Oil (AKO) were investigated in an animal model of bisphenol A (BPA)-induced polycystic ovary syndrome (PCOS). BPA disrupts endocrine functions and indu...
Structural insights and predictive modelling of a novel anti-HER2 scFv and Leptulipin: a newly designed immunotoxin protein for HER2 positive cancers [0.03%]
新型抗HER2单链抗体及Leptulipin：HER2阳性癌症的一种新设计的免疫毒素蛋白及其结构洞察和预测模型
Maria Kalsoom,Hafiz Muzzammel Rehman,Yasamin Al-Qassab et al.
Maria Kalsoom et al.
Targeted therapy is one crucial therapeutic approach frequently employed in cancer treatment. In almost 30% of human breast cancers, a transmembrane tyrosine kinase receptor named the HER2 (human epidermal growth factor receptor 2) is overe...
PGC-1 alpha regulates mitochondrial biogenesis to promote silica-induced pulmonary fibrosis [0.03%]
PGC-1α通过调节线粒体生物生成促进硅肺的发生发展
Xiaoqiang Han,Mei Zhang,Liu Daowei et al.
Xiaoqiang Han et al.
Silicosis is an incurable chronic fibrotic lung disease caused by long-term exposure to respirable silica particles. It is characterized by persistent inflammation and progressive fibrosis of lung tissues, which eventually leads to respirat...