Persistent deficiency of mucosa-associated invariant T (MAIT) cells during alcohol-related liver disease [0.03%]
酒精相关肝病中黏膜相关不变T细胞(MAIT)的持续缺乏
Yujue Zhang,Yuanyuan Fan,Wei He et al.
Yujue Zhang et al.
Background: Alcohol-related liver disease (ALD) is a major cause of chronic liver diseases. Inflammatory response is a basic pathological feature of ALD. Mucosal-associated invariant T(MAIT) cells are a novel population o...
SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation [0.03%]
SNX27通过促进OTULIN的膜定位来抑制线性泛素化及其介导的NF-κB活化
Ruona Shi,Xue Shi,Dajiang Qin et al.
Ruona Shi et al.
Background: Linear ubiquitination is a novel type of ubiquitination that plays important physiological roles in signalling pathways such as tumour necrosis factor (TNF) signalling. However, little is known about the regul...
Current insights into the implications of m6A RNA methylation and autophagy interaction in human diseases [0.03%]
m6A RNA甲基化与自噬相互作用的最新研究进展及其在人类疾病中的影响
Xuechai Chen,Jianan Wang,Muhammad Tahir et al.
Xuechai Chen et al.
Autophagy is a conserved degradation process crucial to maintaining the primary function of cellular and organismal metabolism. Impaired autophagy could develop numerous diseases, including cancer, cardiomyopathy, neurodegenerative disorder...
Changes to the identity of EndoC-βH1 beta cells may be mediated by stress-induced depletion of HNRNPD [0.03%]
内源性压力可通过消耗HNRNPD诱导内分泌细胞身份改变
Nicola Jeffery,David Chambers,Brandon M Invergo et al.
Nicola Jeffery et al.
Background: Beta cell identity changes occur in the islets of donors with diabetes, but the molecular basis of this remains unclear. Protecting residual functional beta cells from cell identity changes may be beneficial f...
Potential of helper-dependent Adenoviral vectors in CRISPR-cas9-mediated lung gene therapy [0.03%]
CRISPR-cas9介导的肺基因治疗中辅助依赖型腺病毒载体的应用潜力
Ranmal Avinash Bandara,Ziyan Rachel Chen,Jim Hu
Ranmal Avinash Bandara
Since CRISPR/Cas9 was harnessed to edit DNA, the field of gene therapy has witnessed great advances in gene editing. New avenues were created for the treatment of diseases such as Cystic Fibrosis (CF). CF is caused by mutations in the Cysti...
Incident disease associations with mosaic chromosomal alterations on autosomes, X and Y chromosomes: insights from a phenome-wide association study in the UK Biobank [0.03%]
常染色体、X和Y染色体上的镶嵌型染色体变异与发病疾病之间的关联：来自英国生物样本库全表型组关联研究的启示
Shu-Hong Lin,Derek W Brown,Brandon Rose et al.
Shu-Hong Lin et al.
Background: Mosaic chromosomal alterations (mCAs) are large chromosomal gains, losses and copy-neutral losses of heterozygosity (LOH) in peripheral leukocytes. While many individuals with detectable mCAs have no notable a...
Exosomal delivery of therapeutic modulators through the blood-brain barrier; promise and pitfalls [0.03%]
通过血脑屏障递送外泌体疗法调节剂的希望与挑战
Morteza Heidarzadeh,Yasemin Gürsoy-Özdemir,Mehmet Kaya et al.
Morteza Heidarzadeh et al.
Nowadays, a large population around the world, especially the elderly, suffers from neurological inflammatory and degenerative disorders/diseases. Current drug delivery strategies are facing different challenges because of the presence of t...
Dexibuprofen ameliorates peripheral and central risk factors associated with Alzheimer's disease in metabolically stressed APPswe/PS1dE9 mice [0.03%]
迪昔布profen改善代谢应激APPswe / PS1dE9小鼠与阿尔茨海默病相关的外周和中枢风险因素
Miren Ettcheto,Elena Sánchez-Lopez,Amanda Cano et al.
Miren Ettcheto et al.
Background: Several studies stablished a relationship between metabolic disturbances and Alzheimer´s disease (AD) where inflammation plays a pivotal role. However, mechanisms involved still remain unclear. In the present...
Genome-wide analysis of protein-protein interactions and involvement of viral proteins in SARS-CoV-2 replication [0.03%]
新型冠状病毒蛋白质间相互作用与宿主功能性互作的全基因组分析及其对SARS-CoV-2复制的影响
Yiling Jiang,Kuijie Tong,Roubin Yao et al.
Yiling Jiang et al.
Background: Analysis of viral protein-protein interactions is an essential step to uncover the viral protein functions and the molecular mechanism for the assembly of a viral protein complex. We employed a mammalian two-h...
Correction to: Electric signals counterbalanced posterior vs anterior PTEN signaling in directed migration of Dictyostelium [0.03%]
Correction to：电信号平衡Dictyostelium定向迁移中PTEN的后部与前部信号转导
Bing Song,Yu Gu,Wenkai Jiang et al.
Bing Song et al.
Published Erratum
Cell & bioscience. 2021 Jul 21;11(1):139. DOI:10.1186/s13578-021-00653-x 2021