A single-cell interactome of human tooth germ from growing third molar elucidates signaling networks regulating dental development [0.03%]
人类第三磨牙生长齿胚的单细胞互作图谱揭示了调控牙齿发育的信号网络
Yueqi Shi,Yejia Yu,Yuqiong Zhou et al.
Yueqi Shi et al.
Background: Development of dental tissue is regulated by extensive cell crosstalk based on various signaling molecules, such as bone morphogenetic protein (BMP) and fibroblast growth factor (FGF) pathways. However, an int...
RNF144A-AS1, a TGF-β1- and hypoxia-inducible gene that promotes tumor metastasis and proliferation via targeting the miR-30c-2-3p/LOX axis in gastric cancer [0.03%]
RNF144A-AS1，一个通过靶向胃癌中的miR-30c-2-3p/LOX轴来促进肿瘤转移和增殖的TGF-β1和低氧诱导基因
Zengliang Li,Liang Shi,Xiangwei Li et al.
Zengliang Li et al.
Background: Although recent molecular analyses have improved our knowledge regarding gastric cancer (GC) biology, the molecular mechanisms that confer metastatic potential to GC remain poorly understood. In this study, we...
Metabolic reprogramming and metabolic sensors in KSHV-induced cancers and KSHV infection [0.03%]
与KSHV感染诱导的癌症相关的代谢重编程和代谢传感器
Tingting Li,Shou-Jiang Gao
Tingting Li
Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic gammaherpesvirus associated with several human cancers. KSHV infection and KSHV-induced anabolic cell proliferation and cellular transformation depend on reprogramming of cellul...
Lipocalin 2 regulates expression of MHC class I molecules in Mycobacterium tuberculosis-infected dendritic cells via ROS production [0.03%]
Lipocalin 2通过ROS生成调节Mycobacterium tuberculosis感染的树突状细胞中的MHC I类分子表达
Ji-Ae Choi,Soo-Na Cho,Junghwan Lee et al.
Ji-Ae Choi et al.
Background: Iron has important roles as an essential nutrient for all life forms and as an effector of the host defense mechanism against pathogenic infection. Lipocalin 2 (LCN2), an innate immune protein, plays a crucial...
β-adrenergic receptor inhibition enhances oncolytic herpes virus propagation through STAT3 activation in gastric cancer [0.03%]
β-肾上腺素能受体抑制通过STAT3激活促进胃癌的溶瘤性疱疹病毒传播
Jiali Hu,Ruitao Lu,Yu Zhang et al.
Jiali Hu et al.
Background: Oncolytic viruses (OVs) are considered a promising therapeutic alternative for cancer. However, OVs could activate the host innate immunity, then impair the viral propagation in tumor cells. In this study, we ...
The hepatic senescence-associated secretory phenotype promotes hepatocarcinogenesis through Bcl3-dependent activation of macrophages [0.03%]
肝衰老相关分泌表型通过Bcl3依赖的激活巨噬细胞促进肝致癌作用
Yihua Huang,Xue Yang,Yan Meng et al.
Yihua Huang et al.
Background: Liver cancer is one of the most common malignancies in the world with a poor prognosis. Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer, accounting for 80-90% of cases. The initiation...
Inferring SARS-CoV-2 functional genomics from viral transcriptome with identification of potential antiviral drugs and therapeutic targets [0.03%]
通过病毒转录组鉴定潜在的抗病毒药物和治疗靶点推断SARS-CoV-2功能基因组学
Xu Pan,Xin Li,Shangwei Ning et al.
Xu Pan et al.
Coronavirus disease 2019 (COVID-19) is an emerging infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and has posed a serious threat to global health. Here, we systematically characterized the tra...
Loss of signal transducer and activator of transcription 3 impaired the osteogenesis of mesenchymal progenitor cells in vivo and in vitro [0.03%]
信号转导及转录激活因子3失活抑制了间充质祖细胞体内外的成骨分化
Zijing Huang,Jingyi Feng,Xin Feng et al.
Zijing Huang et al.
Background: Signal transducer and activator of transcription 3 (Stat3) is a cytoplasmic transcription factor that participates in various biologic processes. Loss of Stat3 causes hyperimmunoglobulin E syndrome, presenting...
Huaier polysaccharides suppress triple-negative breast cancer metastasis and epithelial-mesenchymal transition by inducing autophagic degradation of Snail [0.03%]
华瑞多糖通过诱导Snail的自噬降解来抑制三阴性乳腺癌转移和上皮间质转化
Yuan Tian,Jin Wu,Lingjuan Zeng et al.
Yuan Tian et al.
Background: Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, and the targeted therapies are lacking for this type of cancer. We previously demonstrated that Huaier effectively improve ...
Long noncoding RNA SNHG1 promotes TERT expression by sponging miR-18b-5p in breast cancer [0.03%]
长链非编码RNA SNHG1通过海绵作用miR-18b-5p促进TERT在乳腺癌中表达
Yujuan Kang,Lin Wan,Qin Wang et al.
Yujuan Kang et al.
Background: Long noncoding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) plays a positive role in the progression of human malignant tumors. However, the molecular mechanism of SNHG1 remains elusive in breast cance...