Role of FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases [0.03%]
FoxO转录因子在衰老及与年龄相关的代谢和神经变性疾病中的作用
Shuqi Du,Hui Zheng
Shuqi Du
Aging happens to all of us as we live. Thanks to the improved living standard and discovery of life-saving medicines, our life expectancy has increased substantially across the world in the past century. However, the rise in lifespan leads ...
Allogeneic vs. autologous mesenchymal stem/stromal cells in their medication practice [0.03%]
同种异体与自体的间充质干细胞在药物使用上的区别
Chenghai Li,Hua Zhao,Linna Cheng et al.
Chenghai Li et al.
Mesenchymal stem/stromal cell (MSC)-based therapeutics is already available for treatment of a range of diseases or medical conditions. Autologous or allogeneic MSCs obtained from self or donors have their own advantages and disadvantages i...
Mitochondrial dysfunction, UPRmt signaling, and targeted therapy in metastasis tumor [0.03%]
线粒体功能障碍，UPRmt信号和转移肿瘤的靶向治疗
Rajendiran Keerthiga,De-Sheng Pei,Ailing Fu
Rajendiran Keerthiga
In modern research, mitochondria are considered a more crucial energy plant in cells. Mitochondrial dysfunction, including mitochondrial DNA (mtDNA) mutation and denatured protein accumulation, is a common feature of tumors. The dysfunction...
PRCC reduces the sensitivity of cancer cells to DNA damage by inhibiting JNK and ATM/ATR pathways and results in a poor prognosis in hepatocellular carcinoma [0.03%]
通过抑制JNK和ATM / ATR通路，PRCC降低癌症细胞对DNA损伤的敏感性，并导致肝细胞性肝癌预后不良
Chunying Liu,Xuejing Lin,Bin Sun et al.
Chunying Liu et al.
Background and aim: The proline rich mitotic checkpoint control factor (PRCC) is involved in the splicing process of pre-mRNA. This study aims to elucidate PRCC molecular function, regulatory mechanism and diagnostic valu...
Correction to: Genetic composition and evolution of the prevalent Mycobacterium tuberculosis lineages 2 and 4 in the Chinese and Zhejiang Province populations [0.03%]
更正：中国和浙江人群中流行的结核分枝杆菌谱系2和4的遗传组成及进化过程
Beibei Wu,Wenlong Zhu,Yue Wang et al.
Beibei Wu et al.
Published Erratum
Cell & bioscience. 2021 Oct 21;11(1):184. DOI:10.1186/s13578-021-00692-4 2021
Neuromedin B promotes chondrocyte differentiation of mesenchymal stromal cells via calcineurin and calcium signaling [0.03%]
神经介质B通过钙调磷酸酶和钙信号促进间充质基质细胞的软骨细胞分化
Marie Maumus,Guillaume Fonteneau,Maxime Ruiz et al.
Marie Maumus et al.
Background: Articular cartilage is a complex tissue with poor healing capacities. Current approaches for cartilage repair based on mesenchymal stromal cells (MSCs) are often disappointing because of the lack of relevant d...
Chorionic villus-derived mesenchymal stem cell-mediated autophagy promotes the proliferation and invasiveness of trophoblasts under hypoxia by activating the JAK2/STAT3 signalling pathway [0.03%]
绒毛来源的间充质干细胞介导的自噬通过激活JAK2/STAT3信号通路促进低氧环境下滋养层细胞的增殖和侵袭能力
Yijing Chu,Chengzhan Zhu,Chongyu Yue et al.
Yijing Chu et al.
Background: Trophoblast dysfunction during pregnancy is fundamentally involved in preeclampsia. Several studies have revealed that human chorionic villous mesenchymal stem cells (CV-MSCs) could regulate trophoblasts funct...
Current knowledge and challenges associated with targeted delivery of neurotrophic factors into the central nervous system: focus on available approaches [0.03%]
神经生长因子靶向传递到中枢神经系统的研究现状和挑战：侧重于现有方法
Gozal Bahlakeh,Reza Rahbarghazi,Daruosh Mohammadnejad et al.
Gozal Bahlakeh et al.
During the last decades, numerous basic and clinical studies have been conducted to assess the delivery efficiency of therapeutic agents into the brain and spinal cord parenchyma using several administration routes. Among conventional and i...
RhoA enhances osteosarcoma resistance to MPPa-PDT via the Hippo/YAP signaling pathway [0.03%]
RhoA通过Hippo/YAP信号通路增强骨肉瘤对MPPa-PDT的抵抗性
Fangbiao Zhan,Tao He,Zhiyu Chen et al.
Fangbiao Zhan et al.
Background: Osteosarcoma (OS) is the most prevalent primary bone malignancy affecting adolescents, yet the emergence of chemoradiotherapeutic resistance has limited efforts to cure affected patients to date. Pyropheophorb...
Telomere shortening causes distinct cell division regimes during replicative senescence in Saccharomyces cerevisiae [0.03%]
端粒缩短导致出芽酵母酿酒酵母在复制性衰老期间出现不同的细胞分裂模式
Hugo Martin,Marie Doumic,Maria Teresa Teixeira et al.
Hugo Martin et al.
Background: Telomerase-negative cells have limited proliferation potential. In these cells, telomeres shorten until they reach a critical length and induce a permanently arrested state. This process called replicative sen...