Characterization of novel interactions with membrane NEU1 highlights new regulatory functions for the Elastin Receptor Complex in monocyte interaction with endothelial cells [0.03%]
新型相互作用与膜NEU1的特征表明弹力蛋白受体复合物在单核细胞与内皮细胞相互作用中的新调节功能
Olivier Bocquet,Dignê Tembely,Damien Rioult et al.
Olivier Bocquet et al.
Background: Vascular aging is associated with remodeling of elastin, one of the main extracellular matrix component of the arterial wall, and production of elastin-derived peptides (EDP). These extracellular matrix degrad...
Correction to: Upregulation of IL-15 in the placenta alters trophoblasts behavior contributing to gestational diabetes mellitus [0.03%]
Correction to：胎盘中IL-15上调改变滋养细胞行为导致妊娠糖尿病
Jiaqi Li,Yuan Li,Xuan Zhou et al.
Jiaqi Li et al.
Published Erratum
Cell & bioscience. 2021 Dec 13;11(1):207. DOI:10.1186/s13578-021-00714-1 2021
Single-cell RNA-sequencing reveals distinct immune cell subsets and signaling pathways in IgA nephropathy [0.03%]
单细胞RNA测序揭示IgA肾病中不同的免疫细胞亚群和信号通路
Honghui Zeng,Le Wang,Jiajia Li et al.
Honghui Zeng et al.
Background: IgA nephropathy (IgAN) is the most common primary glomerulonephritis globally. Increasing evidence suggests the importance of host immunity in the development of IgAN, but its dynamics during the early stage o...
Soluble amyloid-beta isoforms predict downstream Alzheimer's disease pathology [0.03%]
可溶性β淀粉样蛋白亚型预测阿尔茨海默病下游病理状况
Guilherme Povala,Bruna Bellaver,Marco Antônio De Bastiani et al.
Guilherme Povala et al.
Background: Changes in soluble amyloid-beta (Aβ) levels in cerebrospinal fluid (CSF) are detectable at early preclinical stages of Alzheimer's disease (AD). However, whether Aβ levels can predict downstream AD pathologi...
A polygenic risk score predicts mosaic loss of chromosome Y in circulating blood cells [0.03%]
多基因风险评分可预测循环血液细胞中染色体Y的嵌合性丢失事件
Moeen Riaz,Jonas Mattisson,Galina Polekhina et al.
Moeen Riaz et al.
Background: Mosaic loss of Y chromosome (LOY) is the most common somatic change that occurs in circulating white blood cells of older men. LOY in leukocytes is associated with increased risk for all-cause mortality and a ...
Intranasal HD-Ad vaccine protects the upper and lower respiratory tracts of hACE2 mice against SARS-CoV-2 [0.03%]
鼻内HD-Ad疫苗可保护hACE2小鼠的上下呼吸道免受SARS-CoV-2侵害
Huibi Cao,Juntao Mai,Zhichang Zhou et al.
Huibi Cao et al.
Background: The ongoing COVID-19 pandemic has resulted in 185 million recorded cases and over 4 million deaths worldwide. Several COVID-19 vaccines have been approved for emergency use in humans and are being used in many...
Low-level laser prevents doxorubicin-induced skeletal muscle atrophy by modulating AMPK/SIRT1/PCG-1α-mediated mitochondrial function, apoptosis and up-regulation of pro-inflammatory responses [0.03%]
低水平激光通过调节AMPK/SIRT1/PCG-1α介导的线粒体功能，凋亡和促进炎症反应的上调来预防多柔比星诱导的骨骼肌萎缩
Hsiu-Chung Ou,Pei-Ming Chu,Yu-Ting Huang et al.
Hsiu-Chung Ou et al.
Background: Doxorubicin (Dox) is a widely used anthracycline drug to treat cancer, yet numerous adverse effects influencing different organs may offset the treatment outcome, which in turn affects the patient's quality of...
Catalase deficiency facilitates the shuttling of free fatty acid to brown adipose tissue through lipolysis mediated by ROS during sustained fasting [0.03%]
过氧化氢酶的缺乏通过持续饥饿期间ROS介导的脂肪分解促进游离脂肪酸向棕色脂肪组织转运
Raghbendra Kumar Dutta,Joon No Lee,Yunash Maharjan et al.
Raghbendra Kumar Dutta et al.
Background: Fatty acids (FA) derived from adipose tissue and liver serve as the main fuel in thermogenesis of brown adipose tissue (BAT). Catalase, a peroxisomal enzyme, plays an important role in maintaining intracellula...
Development of a simple and miniaturized sandwich-like fluorescence polarization assay for rapid screening of SARS-CoV-2 main protease inhibitors [0.03%]
用于快速筛选SARS-CoV-2主蛋白酶抑制剂的简易微型夹心式荧光偏振测定法的开发
Gangan Yan,Dongsheng Li,Yuan Lin et al.
Gangan Yan et al.
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly transmissible and has caused a pandemic named coronavirus disease 2019 (COVID-19), which has quickly spread worldwide. Although several th...
Concurrent mapping of multiple epigenetic marks and co-occupancy using ACT2-seq [0.03%]
使用ACT2-seq同时映射多种表观遗传标记和共占据HeaderCodeHeaderCode
Benjamin Carter,Wai Lim Ku,Joe Pelt et al.
Benjamin Carter et al.
Background: Genome-wide profiling of epigenetic marks is a core technology in molecular genetics. Co-occupancy of different epigenetic marks or protein factors at the same genomic locations must often be inferred from mul...