Antioxidant supplements promote tumor formation and growth and confer drug resistance in hepatocellular carcinoma by reducing intracellular ROS and induction of TMBIM1 [0.03%]
抗氧化剂补充剂通过降低细胞内ROS和诱导TMBIM1促进肝癌的形成、生长及产生耐药性
Vanilla Xin Zhang,Karen Man-Fong Sze,Lo-Kong Chan et al.
Vanilla Xin Zhang et al.
Background: Controversy over the benefits of antioxidants supplements in cancers persists for long. Using hepatocellular carcinoma (HCC) as a model, we investigated the effects of exogenous antioxidants N-acetylcysteine (...
Generation of macrophage containing alveolar organoids derived from human pluripotent stem cells for pulmonary fibrosis modeling and drug efficacy testing [0.03%]
人多能干细胞来源的含巨噬细胞肺泡类器官的构建及其在肺纤维病模建及药物筛选中的应用研究
Hye-Ryeon Heo,Seok-Ho Hong
Hye-Ryeon Heo
Macrophages are a central immune component in various types of in vitro human organoid systems to recapitulate normal and pathological development. However, to date, generation of human alveolar organoids (AOs) containing macrophages for us...
SARS-CoV-2 and COVID-19: revisiting the most important research questions [0.03%]
SARS-CoV-2和COVID-19：重新审视最重要的研究问题
Kit-San Yuen,Zi-Wei Ye,Sin-Yee Fung et al.
Kit-San Yuen et al.
In February 2020, we highlighted the top nine important research questions on SARS-CoV-2 and COVID-19 concerning virus transmission, asymptomatic and presymptomatic virus shedding, diagnosis, treatment, vaccine development, origin of virus ...
Microinjection of antisense oligonucleotides into living mouse testis enables lncRNA function study [0.03%]
反义寡核苷酸注射入小鼠睾丸研究长链非编码RNA功能
Zhaohui Chen,Li Ling,Xiaolian Shi et al.
Zhaohui Chen et al.
Background: Long non-coding RNAs (lncRNAs) have been the focus of ongoing research in a diversity of cellular processes. LncRNAs are abundant in mammalian testis, but their biological function remains poorly known. ...
Zhiqiang Deng,Xiaoting Zhou,Jia-Hong Lu et al.
Zhiqiang Deng et al.
Autophagy is a cell self-digestion pathway through lysosome and plays a critical role in maintaining cellular homeostasis and cytoprotection. Characterization of autophagy related genes in cell and animal models reveals diverse physiologica...
From nasal to basal: single-cell sequencing of the bursa of Fabricius highlights the IBDV infection mechanism in chickens [0.03%]
从鼻窦到基底：单细胞测序揭示了法布里丘氏囊中鸡传染性法氏囊病病毒感染机制
Abid Ullah Shah,Yuchen Li,Wei Ouyang et al.
Abid Ullah Shah et al.
Background: Chickens, important food animals and model organisms, are susceptible to many RNA viruses that invade via the nasal cavity. To determine the nasal entry site of the virus and clarify why avians are susceptible...
Identification of Gm15441, a Txnip antisense lncRNA, as a critical regulator in liver metabolic homeostasis [0.03%]
鉴定出Gm15441（一种Txnip反义lncRNA）是肝脏代谢稳态的关键调节因子
Mingyang Xin,Qian Guo,Qingchun Lu et al.
Mingyang Xin et al.
Background: The majority of mammalian genome is composed of non-coding regions, where numerous long non-coding RNAs (lncRNAs) are transcribed. Although lncRNAs have been identified to regulate fundamental biological proce...
The cGAS-STING pathway: more than fighting against viruses and cancer [0.03%]
cGAS-STING通路：不止是抗病毒和肿瘤免疫
Terigen Bao,Jia Liu,Jiyan Leng et al.
Terigen Bao et al.
In the classic Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS)-stimulator of interferon genes (STING) pathway, downstream signals can control the production of type I interferon and nuclear factor kappa-light-...
SIRT6 inhibition delays peripheral nerve recovery by suppressing migration, phagocytosis and M2-polarization of macrophages [0.03%]
SIRT6抑制通过抑制巨噬细胞的迁移、吞噬作用和M2极化延迟周围神经恢复
Ying Zou,Jiaqi Zhang,Jiawei Xu et al.
Ying Zou et al.
Background: Silent information regulator 6 (SIRT6) is a mammalian homolog of the nicotinamide adenine dinucleotide (NAD)-dependent deacetylase sirtuin family. Prior evidences suggested that the anti-inflammatory function ...
Yun-Fai Chris Lau
Yun-Fai Chris Lau
Three articles published by the research groups led by Yun-Bo Shi of the National Institute of Child Health and Human Development, National Institutes of Health, USA; Aria Baniahmad of the Institute of Human Genetics, Jena University Hospit...