PGC-1α: key regulator of mitochondrial biogenesis and cellular differentiation in metabolic and regenerative tissues [0.03%]
PGC-1α：代谢和再生组织中线粒体生物发生和细胞分化的关键调节因子
Lijuan Cao,Yanan Li,Artem Smirnov et al.
Lijuan Cao et al.
Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is a crucial coactivator that regulates mitochondrial biogenesis and function across diverse tissues, including the brain, heart, skeletal muscle, bone marrow, and live...
Progesterone receptor antagonism by mifepristone impairs trophoblast stemness and promotes apoptosis through upregulation of PDCD4 [0.03%]
米非司酮通过上调PDCD4抑制黄体酮受体，从而抑制胎盘干细胞并促进细胞凋亡
Jie Zhou,Li Yan,Yamei Li et al.
Jie Zhou et al.
Background: Trophoblast cells are a critical component of retained products of conception (RPOC). While mifepristone is widely used as a non-invasive treatment for RPOC, its precise molecular mechanisms in trophoblast reg...
Pluripotent stem cells-based neural organoids for modelling human brain development and diseases [0.03%]
基于多能干细胞的类脑器官模拟人类大脑发育和疾病研究
Lingling Tong,Peiqi Tian,Ruoxi Wang et al.
Lingling Tong et al.
Brain organoids have emerged as transformative in vitro models for studying human neurodevelopment, neural disorders, and evolutionary brain complexity. This review systematically compares neural development in mice and humans, reflecting t...
PRSS55 regulates BCAA metabolism and interacts with BCKDK and BCKDHA in mouse testes and sperm [0.03%]
PRSS55调节支链氨基酸代谢并相互作用于鼠睾丸和精子中的BCKDK和BCKDHA
Haoyang Ge,Chunling Shen,Wenfeng Xiong et al.
Haoyang Ge et al.
Backgrounds: Recent research has emphasized the significance of testis-specific serine proteases in regulating various aspects of sperm maturation and function. Among them, serine protease 55 (PRS55) plays an important ro...
TRIM16 mediates YAP1 K63-linked ubiquitination to alleviate sepsis-induced acute liver injury through YAP/Nrf2 axis in mice [0.03%]
TRIM16介导YAP1的K63链状泛素化通过YAP/Nrf2轴缓解小鼠脓毒症诱导的急性肝损伤
Kaina Zhang,Mengqing Liu,Yeqing Zheng et al.
Kaina Zhang et al.
Sepsis-induced liver injury is associated with high morbidity and mortality, yet its underlying mechanisms remain elucidated. In this study, we observed a significant reduction in the E3 ubiquitin ligase TRIM16 in lipopolysaccharide (LPS)-i...
Shi-Jia Huang,Hui-Lin Ye,Shuo Xu et al.
Shi-Jia Huang et al.
The incidence of inflammatory bowel disease (IBD) has been increasing, and while the interaction between T cells and intestinal microorganisms is crucial in its pathogenesis, the related epigenetic mechanisms remain unclear. This study foun...
Ketogenic diets and metabolic dysfunction-associated steatotic liver disease: a literature review [0.03%]
生酮饮食与代谢性失常脂肪肝病：文献综述
Kexin Sun,Weitian Li,Yunan Chen et al.
Kexin Sun et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is estimated to affect over 30% of the global population with a rising trend, posing significant healthcare burden due to its progression and increased risk of related metabol...
A crucial role of KLF2-regulated mitochondrial oxidative phosphorylation in maintaining the stemness of mesenchymal stem cells derived from bone marrow [0.03%]
KLF2调控的线粒体氧化磷酸化在维持骨髓来源的间充质干细胞干性中的关键作用
Zhiyuan Gong,Yangxi Cheng,Rui Deng et al.
Zhiyuan Gong et al.
Mesenchymal stem cells (MSCs) have many uses in tissue engineering and clinical applications. However, maintaining their stemness during in vitro expansion is challenging. We previously found that Krüppel-like factor 2 (KLF2) plays a cruci...
Cellular prion protein and calcium ions trigger the neurotoxicity of α-synuclein aggregates [0.03%]
细胞内原蛋白和钙离子触发α-突触核蛋白聚集体的神经毒性
Alessandra Bigi,Andrea Carlotta Conti,Liliana Napolitano et al.
Alessandra Bigi et al.
Background: The aggregation of α-Synuclein (αS) into amyloid fibrils and their deposition in intraneuronal Lewy bodies are hallmark features of Parkinson's disease (PD) and other synucleinopathies. Among the molecular p...
A CCL5+CD20+CD8+ T cell subset drives pathogenic transformation of synoviocytes in rheumatoid arthritis via JAK-STAT signaling [0.03%]
携带CCL5+CD20+CD8+受体的T细胞亚群通过JAK-STAT信号转导驱动类风湿性关节炎中滑膜纤维母细胞向病理状态转化
Haonan Jia,Jiawei Xue,Suna Jiang et al.
Haonan Jia et al.