Raheleh Heydari,Zohreh Jangravi,Samaneh Maleknia et al.
Raheleh Heydari et al.
Although sex hormones play a key role in sex differences in susceptibility, severity, outcomes, and response to therapy of different diseases, sex chromosomes are also increasingly recognized as an important factor. Studies demonstrated tha...
Turning the tide on Alzheimer's disease: modulation of γ-secretase [0.03%]
逆转阿尔茨海默病的潮流：γ-分泌酶的作用机制及调控功能研究进展
Joanna E Luo,Yue-Ming Li
Joanna E Luo
Alzheimer's disease (AD) is the most common type of neurodegenerative disorder. Amyloid-beta (Aβ) plaques are integral to the "amyloid hypothesis," which states that the accumulation of Aβ peptides triggers a cascade of pathological event...
Offspring production of haploid spermatid-like cells derived from mouse female germline stem cells with chromatin condensation [0.03%]
具有染色质凝聚的小鼠雌性生殖细胞干细胞来源的单倍体精子样细胞的后代产生
Xiaopeng Hu,Hu Wang,Geng G Tian et al.
Xiaopeng Hu et al.
Background: During male meiosis, the Y chromosome can form perfect pairing with the X chromosome. However, it is unclear whether mammalian Female germline stem cells (FGSCs) without a Y chromosome can transdifferentiate i...
Ontogeny of RORγt+ cells in the intestine of newborns and its role in the development of experimental necrotizing enterocolitis [0.03%]
新生儿肠道RORγt⁺细胞的发育及其在实验性坏死性小肠结肠炎发病机制中的作用
Xiuhao Zhao,Wenhua Liang,Yonghui Wang et al.
Xiuhao Zhao et al.
Background: Neonates possess an immature and plastic immune system, which is a major cause of some diseases in newborns. Necrotizing enterocolitis (NEC) is a severe and devastating intestinal disease that typically affect...
The interplay of autophagy and oxidative stress in the pathogenesis and therapy of retinal degenerative diseases [0.03%]
自噬和氧化应激在视网膜退行性疾病发病机制和治疗中的相互作用
Kun-Che Chang,Pei-Feng Liu,Chia-Hsuan Chang et al.
Kun-Che Chang et al.
Oxidative stress is mainly caused by intracellular reactive oxygen species (ROS) production, which is highly associated with normal physiological homeostasis and the pathogenesis of diseases, particularly ocular diseases. Autophagy is a sel...
BVES is a novel interactor of ANO5 and regulates myoblast differentiation [0.03%]
BVES是ANO5的新互作蛋白并调控肌管分化
Haiwen Li,Li Xu,Yandi Gao et al.
Haiwen Li et al.
Background: Anoctamin 5 (ANO5) is a membrane protein belonging to the TMEM16/Anoctamin family and its deficiency leads to the development of limb girdle muscular dystrophy R12 (LGMDR12). However, little has been known abo...
Maresin conjugates in tissue regeneration-1 suppresses ferroptosis in septic acute kidney injury [0.03%]
马雌激素衍生物在脓毒性急性肾损伤中抑制铁死亡
Ji Xiao,Qian Yang,Ye&#x;an Zhang et al.
Ji Xiao et al.
Background: Ferroptosis is unique among different types of regulated cell death and closely related to organ injury. Whether ferroptosis occurs in sepsis-associated acute kidney injury (SA-AKI) is not clear. Nuclear facto...
Exosomes originating from infection with the cytoplasmic single-stranded RNA virus Rift Valley fever virus (RVFV) protect recipient cells by inducing RIG-I mediated IFN-B response that leads to activation of autophagy [0.03%]
胞质单链RNA病毒裂谷热病毒(RVFV)感染来源的外泌体通过诱导RIG-I介导的IFN-β应答激活自噬来保护靶细胞
Farhang Alem,Adeyemi A Olanrewaju,Samson Omole et al.
Farhang Alem et al.
Background: Although multiple studies have demonstrated a role for exosomes during virus infections, our understanding of the mechanisms by which exosome exchange regulates immune response during viral infections and affe...
The eukaryotic initiation factor 5A (eIF5A1), the molecule, mechanisms and recent insights into the pathophysiological roles [0.03%]
真核起始因子5A（eIF5A1）的分子、机制及其病理生理作用的最新研究进展
Michel Tauc,Marc Cougnon,Romain Carcy et al.
Michel Tauc et al.
Since the demonstration of its involvement in cell proliferation, the eukaryotic initiation factor 5A (eIF5A) has been studied principally in relation to the development and progression of cancers in which the isoform A2 is mainly expressed...
Genetically modified large animal models for investigating neurodegenerative diseases [0.03%]
神经退行性疾病的转基因大型动物模型研究
Weili Yang,Xiusheng Chen,Shihua Li et al.
Weili Yang et al.
Neurodegenerative diseases represent a large group of neurological disorders including Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, and Huntington's disease. Although this group of diseases show heterogeneous cli...