Transcriptional landscape of circulating platelets from patients with COVID-19 reveals key subnetworks and regulators underlying SARS-CoV-2 infection: implications for immunothrombosis [0.03%]
对COVID-19患者循环血小板的转录组解析揭示了SARS-CoV-2感染免疫血栓形成的关键子网络和调节因子
Weiping Ji,Lu Chen,Wei Yang et al.
Weiping Ji et al.
Background: Thrombosis and coagulopathy are pervasive pathological features of coronavirus disease 2019 (COVID-19), and thrombotic complications are a sign of severe COVID-19 disease and are associated with multiple organ...
Pseudomonas aeruginosa modulates alginate biosynthesis and type VI secretion system in two critically ill COVID-19 patients [0.03%]
铜绿假单胞菌在两例重症COVID-19患者中调节海藻酸生物合成和VI型分泌系统
Jiuxin Qu,Zhao Cai,Xiangke Duan et al.
Jiuxin Qu et al.
Background: COVID-19 pneumonia has caused huge impact on the health of infected patients and associated with high morbidity and mortality. Shift in the lung microbial ecology upon such viral infection often worsens the di...
Single-cell analysis of mouse uterus at the invasion phase of embryo implantation [0.03%]
小鼠胚胎着床侵袭期子宫单细胞核转录组图谱
Jia-Peng He,Qing Tian,Qiu-Yang Zhu et al.
Jia-Peng He et al.
Background: Embryo implantation into the uterus is a crucial step for human reproduction. A hypothesis has been proposed that the molecular circuit invented by trophoblasts for invasive embryo implantation during evolutio...
YBX1 mediates alternative splicing and maternal mRNA decay during pre-implantation development [0.03%]
YBX1在植入前发育过程中介导选择性剪接和母源mRNA降解
Mingtian Deng,Baobao Chen,Zifei Liu et al.
Mingtian Deng et al.
Background: In mammals, maternal gene products decay and zygotic genome activation (ZGA) during maternal to zygotic transition (MZT) is critical for the early embryogenesis. Y-box binding protein YBX1 plays vital roles in...
The common incidence-age multistep model of neurodegenerative diseases revisited: wider general age range of incidence corresponds to fewer disease steps [0.03%]
从新视角审视神经退行性疾病的共病率-年龄多步模型：更广的发病年龄段对应更少的疾病步骤
Daniela Gerovska,Marcos J Araúzo-Bravo
Daniela Gerovska
Background: Previously, we collected age-stratified incidence data of 404 epidemiological datasets of 10 neurodegenerative diseases (NDs), namely Amyotrophic Lateral Sclerosis (ALS), Alzheimer's disease (AD), Parkinson's ...
The integrin beta1 modulator Tirofiban prevents adipogenesis and obesity by the overexpression of integrin-linked kinase: a pre-clinical approach in vitro and in vivo [0.03%]
整合素β1调制剂Tirofiban通过体内和体外整合素连接激酶的过表达来预防脂肪细胞生成和肥胖：一项临床前研究
S de Frutos,M Griera,M Hatem-Vaquero et al.
S de Frutos et al.
Background: Obesity is caused by the enlargement of the white adipose tissue (WAT) depots, characterized by the hypertrophic enlargement of malfunctioning adipocytes within WAT which increases the storage of triglycerides...
Ubiquitinated AIF is a major mediator of hypoxia-induced mitochondrial dysfunction and pulmonary artery smooth muscle cell proliferation [0.03%]
泛素化AIF是低氧诱导的线粒体功能障碍和肺动脉平滑肌细胞增殖的主要介导因子
Cui Ma,Xiaoying Wang,Siyu He et al.
Cui Ma et al.
Background: Excessive proliferation of pulmonary artery smooth muscle cells (PASMCs) is the main cause of hypoxic pulmonary hypertension (PH), and mitochondrial homeostasis plays a crucial role. However, the specific mole...
Transcriptome-scale spatial gene expression in rat arcuate nucleus during puberty [0.03%]
青春期大鼠下丘脑弓状核转录组水平的空间基因表达
Shasha Zhou,Shaolian Zang,Yanping Hu et al.
Shasha Zhou et al.
Background: A variety of neurons in hypothalamus undergo a complicated regulation on transcription activity of multiple genes for hypothalamic-pituitary-gonadal axis activation during pubertal development. Identification ...
Activation of TCA cycle restrains virus-metabolic hijacking and viral replication in mouse hepatitis virus-infected cells [0.03%]
激活TCA循环可限制鼠肝炎病毒感染细胞时病毒对代谢的重新编程及病毒复制
Sang R Lee,Jeong Yeon Roh,Jihoon Ryu et al.
Sang R Lee et al.
Background: One of coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused coronavirus disease 2019 (COVID-19) pandemic and threatened worldwide. However, therapy for COVID-19 has rarely been...
Replication and transcription machinery for ranaviruses: components, correlation, and functional architecture [0.03%]
裂谷热病毒复制和转录机器：组分、相关性及功能结构
Fei Ke,Xue-Dong Yu,Zi-Hao Wang et al.
Fei Ke et al.
Background: Ranaviruses (family Iridoviridae) are promiscuous pathogens that can infect across species barriers in poikilotherms and can replicate in amphibian and fish cells and even in cultured mammalian cells. However,...