Regulation of paternal 5mC oxidation and H3K9me2 asymmetry by ERK1/2 in mouse zygotes [0.03%]
ERK1/2通过调节父本5mC氧化及H3K9me2不对称分布调控小鼠受精卵的发育
Baobao Chen,Mingtian Deng,Meng-Hao Pan et al.
Baobao Chen et al.
Background: Extracellular-signal-regulated kinase (ERK) direct cell fate determination during the early development. The intricate interaction between the deposition of H3K9me2, de novo 5mC, and its oxides affects the rem...
Long non-coding RNAs and microRNAs as crucial regulators in cardio-oncology [0.03%]
长链非编码RNA和微小RNA在心血管肿瘤学中的重要作用
Sarath Babu Nukala,Jordan Jousma,Yoonje Cho et al.
Sarath Babu Nukala et al.
Cancer is one of the leading causes of morbidity and mortality worldwide. Significant improvements in the modern era of anticancer therapeutic strategies have increased the survival rate of cancer patients. Unfortunately, cancer survivors h...
The promoting effects of activated olfactory ensheathing cells on angiogenesis after spinal cord injury through the PI3K/Akt pathway [0.03%]
活化嗅鞘细胞通过PI3K/Akt信号通路促进脊髓损伤后血管生成的作用及机制研究
Xiaohui Wang,Chao Jiang,Yongyuan Zhang et al.
Xiaohui Wang et al.
Objective: The aim of this study was to investigate the pro-angiogenic potential of olfactory ensheathing cells (OECs) activated by curcumin (CCM) and lipopolysaccharide (LPS) and the possible underlying mechanisms. ...
A missing piece of the puzzle in pulmonary fibrosis: anoikis resistance promotes fibroblast activation [0.03%]
特发性肺纤维化中成纤维细胞活化的另一驱动因素： anchorage independence诱导的抗凋亡作用
Juan Yin,Jing Wang,Xinxin Zhang et al.
Juan Yin et al.
Background: Pulmonary fibrosis initiates a pneumonic cascade that leads to fibroblast dysfunction characterized by excess proliferation. Anoikis is a physiological process that ensures tissue development and homeostasis. ...
The dual role of p62 in ferroptosis of glioblastoma according to p53 status [0.03%]
根据p53状态，p62在胶质母细胞瘤铁死亡中的双重作用
Fanen Yuan,Qian Sun,Si Zhang et al.
Fanen Yuan et al.
Background: Ferroptosis plays a key role in human cancer, but its function and mechanism in glioma is not clear. P62/SQSTM1 was reported to inhibit ferroptosis via the activation of NRF2 signaling pathway. In this study w...
Unconventional protein post-translational modifications: the helmsmen in breast cancer [0.03%]
非传统蛋白质翻译后修饰：乳腺癌的“领航者”
Jiena Liu,Qin Wang,Yujuan Kang et al.
Jiena Liu et al.
Breast cancer is the most prevalent malignant tumor and a leading cause of mortality among females worldwide. The tumorigenesis and progression of breast cancer involve complex pathophysiological processes, which may be mediated by post-tra...
YTHDF1 promotes breast cancer progression by facilitating FOXM1 translation in an m6A-dependent manner [0.03%]
YTHDF1通过m6A依赖方式促进FOXM1翻译从而加速乳腺癌进展
Hengyu Chen,Yuanhang Yu,Ming Yang et al.
Hengyu Chen et al.
Background: N6-methyladenosine (m6A) is the most common post-transcriptional modification at the RNA level. However, the exact molecular mechanisms of m6A epigenetic regulation in breast cancer remain largely unknown and ...
Insight into the mitochondrial unfolded protein response and cancer: opportunities and challenges [0.03%]
线粒体未折叠蛋白反应与癌症：机遇和挑战
Ge Wang,Yumei Fan,Pengxiu Cao et al.
Ge Wang et al.
The mitochondrial unfolded protein response (UPRmt) is an evolutionarily conserved protective transcriptional response that maintains mitochondrial proteostasis by inducing the expression of mitochondrial chaperones and proteases in respons...
Role of ammonia for brain abnormal protein glycosylation during the development of hepatitis B virus-related liver diseases [0.03%]
氨对乙型肝炎相关肝脏疾病发展过程中脑异常蛋白糖基化的作用
Jiajun Yang,Mengqi Yin,Yao Hou et al.
Jiajun Yang et al.
Background: Ammonia is the most typical neurotoxin in hepatic encephalopathy (HE), but the underlying pathophysiology between ammonia and aberrant glycosylation in HE remains unknown. ...
Autophagy-mediated degradation of NOTCH1 intracellular domain controls the epithelial to mesenchymal transition and cancer metastasis [0.03%]
自噬介导的NOTCH1胞内区降解控制上皮间质转化和癌症转移
Sahib Zada,Jin Seok Hwang,Trang Huyen Lai et al.
Sahib Zada et al.
Backgound: Autophagy controls levels of cellular components during normal and stress conditions; thus, it is a pivotal process for the maintenance of cell homeostasis. In cancer, autophagy protects cells from cancerous tr...