Diabetes as a potential compounding factor in COVID-19-mediated male subfertility [0.03%]
糖尿病可能是COVID-19介导的男性生育力下降的潜在加重因素
Qingkui Jiang,Thomas Linn,Karl Drlica et al.
Qingkui Jiang et al.
Recent work indicates that male fertility is compromised by SARS-CoV-2 infection. Direct effects derive from the presence of viral entry receptors (ACE2 and/or CD147) on the surface of testicular cells, such as spermatocytes, Sertoli cells,...
Siah-1-interacting protein regulates mutated huntingtin protein aggregation in Huntington's disease models [0.03%]
西尔斯蛋白通过与SIH1结合调控亨廷顿舞蹈病中突变型亨廷顿蛋白的聚集作用
Ewelina Latoszek,Małgorzata Wiweger,Jan Ludwiczak et al.
Ewelina Latoszek et al.
Background: Huntington's disease (HD) is a neurodegenerative disorder whereby mutated huntingtin protein (mHTT) aggregates when polyglutamine repeats in the N-terminal of mHTT exceeds 36 glutamines (Q). However, the mecha...
BRD4 inhibitor GNE987 exerts anti-cancer effects by targeting super-enhancers in neuroblastoma [0.03%]
BRD4抑制剂GNE987通过靶向神经母细胞瘤中的超级增强子发挥抗癌作用
Yan-Ling Chen,Xiao-Lu Li,Gen Li et al.
Yan-Ling Chen et al.
Background: Neuroblastoma (NB) is a common extracranial malignancy with high mortality in children. Recently, super-enhancers (SEs) have been reported to play a critical role in the tumorigenesis and development of NB via...
Rapid and robust derivation of mesenchymal stem cells from human pluripotent stem cells via temporal induction of neuralized ectoderm [0.03%]
通过诱导神经外胚层临时分化高效快速地从人多能干细胞中分离间充质干细胞
Wei Jin,Yi He,Tuo Li et al.
Wei Jin et al.
Background: Mesenchymal stem cells (MSCs) are emerging as the mainstay of regenerative medicine because of their ability to differentiate into multiple cell lineages. The infinite proliferative potential of human pluripot...
TSLP regulates mitochondrial ROS-induced mitophagy via histone modification in human monocytes [0.03%]
人类单核细胞中TSLP通过组蛋白修饰调节线粒体ROS诱导的自噬作用
Yi-Ching Lin,Yu-Chih Lin,Mei-Lan Tsai et al.
Yi-Ching Lin et al.
Background: Thymic stromal lymphopoietin (TSLP) is a Th2-like cytokine involved in asthma pathogenesis. Excessive reactive oxygen species (ROS) production can lead to airway inflammation, hyperresponsiveness and remodelin...
Second malignant neoplasms in lymphomas, secondary lymphomas and lymphomas in metabolic disorders/diseases [0.03%]
淋巴瘤中的继发性恶性肿瘤、继发性淋巴瘤和代谢性疾病/疾病的淋巴瘤
Youxi Yu,Xiaoju Shi,Xingtong Wang et al.
Youxi Yu et al.
With inconsistent findings, evidence has been obtained in recent years that metabolic disorders are closely associated with the development of lymphomas. Studies and multiple analyses have been published also indicating that some solid tumo...
Transcriptomic characterization of tissues from patients and subsequent pathway analyses reveal biological pathways that are implicated in spastic ataxia [0.03%]
转录组特征鉴定及通路分析揭示与痉挛性共济失调相关的生物通路
Andrea C Kakouri,Christina Votsi,Anastasis Oulas et al.
Andrea C Kakouri et al.
Background: Spastic ataxias (SAs) encompass a group of rare and severe neurodegenerative diseases, characterized by an overlap between ataxia and spastic paraplegia clinical features. They have been associated with pathog...
Causal association evaluation of diabetes with Alzheimer's disease and genetic analysis of antidiabetic drugs against Alzheimer's disease [0.03%]
糖尿病与阿尔茨海默病的因果关系评价及抗糖尿病药物治疗阿尔茨海默病的遗传分析
Lei Meng,Zhe Wang,Hong-Fang Ji et al.
Lei Meng et al.
Background: Despite accumulating epidemiological studies support that diabetes increases the risk of Alzheimer's disease (AD), the causal associations between diabetes and AD remain inconclusive. The present study aimed t...
Generation of immunodeficient pig with hereditary tyrosinemia type 1 and their preliminary application for humanized liver [0.03%]
酪氨酸血症Ⅰ型免疫缺陷猪的制备及人源化肝脏的初步应用研究
Jilong Ren,Dawei Yu,Jing Wang et al.
Jilong Ren et al.
Background: Mice with humanized livers are important models to study drug toxicology testing, development of hepatitis virus treatments, and hepatocyte transplantation therapy. However, the huge difference between mouse a...
Decoding ceRNA regulatory network in the pulmonary artery of hypoxia-induced pulmonary hypertension (HPH) rat model [0.03%]
低氧诱导肺动脉高压模型中解码ceRNA调控网络
Jun Wang,Yanqin Niu,Lingjie Luo et al.
Jun Wang et al.
Background: Hypoxia-induced pulmonary hypertension (HPH) is a lethal cardiovascular disease with the characteristic of severe remodeling of pulmonary vascular. Although a large number of dysregulated mRNAs, lncRNAs, circR...